Abstract: A method to provide active noise control to reduce noise and vibration in reverberant acoustic enclosures such as aircraft, vehicles, appliances, instruments, industrial equipment and the like is presented. A continuous-time multi-input multi-output (MIMO) state space mathematical model of the plant is obtained via analytical modeling and system identification. Compensation is designed to render the mathematical model passive in the sense of mathematical system theory. The compensated system is checked to ensure robustness of the passive property of the plant. The check ensures that the passivity is preserved if the mathematical model parameters are perturbed from nominal values. A passivity-based controller is designed and verified using numerical simulations and then tested. The controller is designed so that the resulting closed-loop response shows the desired noise reduction.

Abstract: Signal distribution of a regional signal is described. An integrated circuit includes a global signal distribution network, a regional signal distribution network and a regional buffer. The regional buffer has an output coupled at an end of the regional signal distribution network. The regional signal distribution network is coupled to a configurable logic block via an interconnect tile. The regional buffer is coupled to a regional clock capable input/output block. Additionally described is a source synchronous interface for regional signal distribution.

Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Abstract: The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.

Abstract: The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.

Abstract: A data alignment and deskewing module includes a delay calibration unit, a data alignment and deskew unit, and a delay unit. The delay calibration unit is operably coupled to generate a reference signal based on a reference clock and a mirrored delay line output signal. The data alignment and deskew unit is operably coupled to determine a delay selection signal based on a delayed and deskewed representation of an input data stream and propagation delay of a line on which the input data stream is received. The delay unit is operably coupled to produce the delayed and deskewed representation of the input data stream based on the reference signal and the delay selection signal.

Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Abstract: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.

Abstract: The present invention relates to one or more peptides which may be used to test for the presence of antibodies to B. microti. These peptide are selected based on the strength and specificity of the human antibody response to B. microti. These peptides alone or in combination have a variety of uses, for example, as a component of a diagnostic assay or kit.

Abstract: A clock distribution network having: a main trunk configured to provide a differential clock signal; a plurality of branches coupled to the main trunk for distributing the differential clock signal to a plurality of circuit elements on the integrated circuit; and a plurality of switches coupling the main trunk to the plurality of branches.

Abstract: Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided.

Abstract: A clock distribution network having: a backbone clock signal line configured to provide a differential clock signal; multiple branches coupled to the backbone clock signal line for distributing the differential clock signal to multiple programmable function elements; a first leaf node coupled to a first branch, where the first leaf node is configured to provide the differential clock signal to a first programmable function element; and a second leaf node coupled to a second branch, where the second leaf node is configured to provide a single ended clock signal derived from the differential clock signal to a second programmable function element.

Abstract: The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a selenium analog of a competitive inhibitor of the hERG K+ channel. Next, the amount of the selenium analog of the competitive inhibitor that bound to the hERG K+ channel is quantified using mass spectrometry. The quantified amount can then be used to determine the amount of the compound of interest that bound to the hERG K+ channel. A selenium analog of any competitive inhibitor of the hERG K+ channel may be used according to the present invention, including but not limited to selenium analogs of the small molecule dofetilide; the peptide BeKm-1; or a combination of both.

Abstract: A clock distribution network having: a main trunk configured to provide a differential clock signal; a plurality of branches coupled to the main trunk for distributing the differential clock signal to a plurality of circuit elements on the integrated circuit; and a plurality of switches coupling the main trunk to the plurality of branches.

Abstract: Signal distribution of a regional signal is described. A programmable logic device includes a global signal distribution network, a regional signal distribution network and a regional buffer. The regional buffer has an output coupled at an end of the regional signal distribution network. The regional signal distribution network is coupled to a configurable logic block via an interconnect tile. The regional buffer is coupled to a regional clock capable input/output block. Additionally described is a source synchronous interface for regional signal distribution.

Abstract: The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a selenium analog of a competitive inhibitor of the hERG K+ channel. Next, the amount of the selenium analog of the competitive inhibitor that bound to the hERG K+ channel is quantified using mass spectrometry. The quantified amount can then be used to determine the amount of the compound of interest that bound to the hERG K+ channel. A selenium analog of any competitive inhibitor of the hERG K+ channel may be used according to the present invention, including but not limited to selenium analogs of the small molecule dofetilide; the peptide BeKm-1; or a combination of both.

Abstract: Method and apparatus for doubling the throughput rate of data transmission on a logic path comprising providing two latches that alternately receive successive bits of the data stream to be transmitted and a multiplexer having data transmission paths that are alternately clocked by two separate clocks, which clocks are substantially 180 degrees out of phase.

Abstract: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the analyte.

Abstract: One or more configurable transceivers can be fabricated on an integrated circuit. The transceivers contain various components having options that can be configured by turning configuration memory cells on or off. The integrated circuit may also contain programmable fabric. Other components in the transceivers can have options that are controlled by the programmable fabric. The integrated circuit may also contain one or more processor cores. The processor core and the transceivers can be connected by a plurality of signal paths that pass through the programmable fabric.