Abstract: Novel tools and techniques are provided for implementing software-based network probes for monitoring network devices for fault management. In various embodiments, a computing system may receive, from at least one software-based network probe, a first alert associated with a first device among layer 4 devices disposed in a plurality of networks; may parse and store first alert data from the received first alert in a database, in a standardized format; may perform, using an enrichment system, enrichment of the first alert data, by retrieving first enrichment data from one or more second databases and adding the first enrichment data to the parsed and formatted first alert data in the first database to form first consolidated alert data; and may send the first consolidated alert data to a fault management system for display to a user to facilitate addressing of the first alert by the user.

Abstract: According to an aspect, there is provided a computer implemented method performed by a patient monitoring device. The method comprises using a patient monitoring model to determine a health parameter for a subject. The method further comprises using one or more outputs of the patient monitoring model to determine a search query with which to query a database of medical images in order to retrieve a matching medical image relevant to the determined health parameter.

Abstract: Expandable vascular introducer sheath devices, systems and method for low profile delivery, expansion to accommodate intravascular devices, and recovery for subsequent removal. The expandability features may be incorporated into other intravascular devices such as guide extension catheters, thrombus removal devices, etc.

Abstract: The present invention relates to compounds of Formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Delivery systems for implanting cardiac valve repair devices are disclosed herein. In some embodiments, a delivery system includes a delivery catheter, a hub shaft extending through the delivery catheter, and a core shaft extending through the hub shaft. The delivery catheter is configured to hold a valve repair device in a compressed configuration. The hub shaft includes a hub configured to releasably engage a first portion of the valve repair device, and the core shaft includes a plug configured to releasably engage a second portion of the valve repair device. When the valve repair device is unsheathed from the delivery catheter, the hub shaft and the core shaft are independently movable to axially elongate/compress the valve repair device. When the valve repair device is properly positioned, the hub can be actuated to release the first portion of the valve repair device, and the plug can be actuated to release the second portion of the valve repair device.

Abstract: A computer-implemented method for validating ownership of a digital asset is disclosed. The computer-implemented method includes transmitting a public key for encrypting a digital asset to an owner of the digital asset responsive to receiving a request for the public key. The computer-implemented method further includes receiving from the owner of the digital asset, an encrypted digital asset and a first liveness hash, wherein the digital asset is encrypted using the public key, and the first liveness hash is generated based, at least in part, on the digital asset in an unencrypted form and a first nonce. The computer-implemented method further includes determining whether the first liveness hash is valid. The computer-implemented method further includes generating in response to determining that the first liveness hash is valid, a digital asset record, wherein the digital asset record includes the encrypted digital asset and the first liveness hash.

Abstract: The present disclosure provides isolated Pseudomonas koreensis strains useful for enhancing crop yield, as well as inoculant compositions comprising one or more of the isolated strains, seeds that have been treated with one or more of the isolated strains, and methods of using the isolated strains to enhance root growth, nutrient uptake, chlorophyll content, etc.

Abstract: A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: A linear pump includes a centrally-disposed drive system and a plunger having a center portion coupled to the drive system, and first and second fluid ends disposed at the first and second ends of the plunger. The pump further includes first and second packing seals each being disposed about the plunger to isolate fluids within the respective first and second fluid ends. First and second adapters are disposed at an interface between the drive system and respective first and second fluid ends, each adapter incorporating an angled deflector configured to deflect and redirect high-pressure fluids escaping past the respective packing seal toward the drive system.

Abstract: A system comprising: a source of a tape comprising a material associated with an adhesive and at least one removable liner; an applicator head; a cutting mechanism; at least one drive feeding mechanism configured to index the tape from the source to the applicator head at a controlled rate; wherein the applicator head is controllable to apply the material on a surface or a substrate; and wherein the applicator head comprises a cutting mechanism configured to sever the material while leaving the at least one removable liner intact.

Abstract: A therapeutic system comprises an ocular insert placed on a region outside an optical zone of an eye. The ocular insert comprises two structures: a first skeletal structure and a second cushioning structure. The first structure functions as a skeletal frame which maintains positioning of the implant along the anterior portion of the eye and provides support to the second, cushioning structure. This first structure maintains the attachment of the therapeutic system to the anterior portion of the eye for at least thirty days. In some embodiments the first structure remains a constant size and shape, e.g. a ring shape, a ring with haptics, or a curvilinear ring that is confined to and restrainingly engages the inferior and superior conjunctival fornices so as to retain the implant within the tear fluid and/or against the tissues of the eye.

Abstract: This disclosure describes systems, methods, and devices related to estimating a provisioning of resources in a telecommunications network. A method may include receiving, at a first time, a user request for a service facilitated by a telecommunications network; identifying, based on the service, a device or port to which the user connects to access the telecommunications network; retrieving, using discovery commands, information from one or more additional devices in the telecommunications network; identifying, based on the information, a second device to which the device or port may connect to generate a path to an endpoint of the telecommunications network; identifying, based on the device or port and the second device, a path from the location of the user to the endpoint in the telecommunications network; generating an estimated time to provision the service using the path; and presenting, at the first time, the estimated time to provision the service.

Abstract: A combustor assembly for a gas turbine engine includes a dome having a forward surface and an inner surface. The forward surface and the inner surface of the dome at least partially define a slot. The combustor assembly also includes a liner at least partially defining a combustion chamber and extending between an aft end and a forward end. The forward end of the liner is positioned within the slot of the dome. The forward end of the liner includes an axial interface surface and a radial interface surface. The axial interface surface defines a radial gap with the inner surface of the dome and the radial interface surface defines an axial gap with the forward surface of the dome. At least one of the radial gap or the axial gap is less than about 0.150 inches during operating conditions of the combustor assembly to prevent an undesirable airflow.

Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: A combined near infrared spectroscopy (NIRS) and ultrasound imaging system acquires NIRS image data and ultrasound image data of the cranium and. using geometric information of the ultrasound transducer and the NIRS emitters and sensors, this information is reformatted and fused into a 3D dataset. Information from NIRS and ultrasound images that indicates relevant regions to be analyzed is extracted from the spatially related data. These regions can either be specific anatomical regions such as vessel structures identified in transcranial ultrasound or regions where the acquired data might indicate stroke. Detection algorithms for relevant regions can be based on neural networks and deep learning-based approaches.

Abstract: An ultrasound system includes a processor circuit that receives an ultrasound image obtained according to a set of ultrasound system settings. The processor circuit determines a quality index representative of the visibility of an anatomical feature for the ultrasound image. In response to determining that the quality index does not meet or exceed a threshold quality index, the processor circuit may provide an output for a new set of ultrasound system settings corresponding to an improvement in quality index. The processor circuit then receives an additional ultrasound image corresponding to the new ultrasound system settings, determines an additional quality index for the additional ultrasound image, determines that the quality index exceeds the threshold quality index, and records the additional ultrasound image.

Abstract: A system is provided for carbon dioxide (CO2) emission recovery. The system includes a methanization reactor. The methanization reactor is configured to receive CO2 separated from one or more off gases of a brake manufacturing process, receive hydrogen (H2) produced from an electrolysis process, convert the CO2 and the H2 via methanization reaction to produce methane (CH4), and supply the produced CH4 to at least one of a carbon/carbon (C/C) preform production process or another system for heat generation.

Abstract: Disclosed herein are compounds for treating a condition modulated by calcium channel ion activity and pharmaceutical compositions comprising the compounds, including the compounds comprising a piperazine core, a 1,4-diazepane core or a 1,5-diazepane core. Also disclosed herein are methods using the compounds to treat a disease or condition relating to aberrant function or activity of a T-type calcium channel.

Abstract: A dual-bearing assembly includes an annular cantilever beam spring positioned in-line and either internal or external to a pair of bearings. The spring includes first and second sets of N stand-offs evenly positioned around opposing top and bottom surfaces of a flat annular beam at 360/N degree intervals and angularly offset with respect to each other by 360/2N degrees such that each said stand-off is evenly spaced between adjacent pairs of stand-offs on the opposing surface. A pre-load mechanism is configured to apply opposing axial loads to the stand-offs to deflect the flat annular beam axially at each stand-off in opposing directions to induce a curvature to the annular beam and store energy in the beam to form load paths through the spring and rolling elements to pre-load the dual-bearing assembly. The dual-bearing assembly may be configured as DB, DF, universal or tandem.