Abstract: The present invention relates to a therapeutic brassiere garment for healing or easing breast pain related to breastfeeding, surgery, menstruation, childbirth and more. The therapeutic brassiere garment features front panels with cups for covering and supporting breasts. Each front panel includes a pocket for holding a therapeutic pad. The therapeutic pad can be put in a microwave for heating and/or in a refrigerator/freezer for cooling and can then be accommodated in the pockets of the garment for providing hot and/or cold therapy. The garment comes in different sizes and styles available for pain relief due to any type of condition. Each pocket includes three sewn sides and an opening for preventing the therapeutic pad from slipping into inappropriate or uncomfortable positions while wearing the brassiere garment.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may be useful in the treatment of infertility associated with PCOS.

Abstract: Novel tools and techniques are provided for implementing real-time fault management or real-time fault management system (“RFM”). In various embodiments, RFM may receive alerts from or associated with network devices (e.g., layer 2, 3, and/or 4 devices, or the like) that are disposed in a plurality of disparate networks that may utilize different alert management protocols and/or different fault management protocols. RFM may collect, enrich, normalize, aggregate, and display the alerts in a user interface to facilitate addressing of the alerts by a user. To enable continuous and real-time functionality, RFM may be implemented in a plurality of siloed platforms in a primary data center, with processing of alerts being load balanced across the siloed platforms, with mirrored group of siloed platforms in a secondary data center located geographically distant from the primary data center and configured to be on “hot standby” and to completely take over RFM processing operations.

Abstract: A method of training a supervised machine learning system to detect anomalies within transaction data is described. The method includes obtaining a training set of data samples; assigning a label indicating an absence of an anomaly to unlabelled data samples in the training set; partitioning the data of the data samples in the training set into two feature sets, a first feature set representing observable features and a second feature set representing context features; generating synthetic data samples by combining features from the two feature sets that respectively relate to two different uniquely identifiable entities; assigning a label indicating a presence of an anomaly to the synthetic data samples; augmenting the training set with the synthetic data samples; and training a supervised machine learning system with the augmented training set and the assigned labels.

Abstract: The invention relates to compounds of Formula (I)-(III) and pharmaceutically acceptable salts thereof to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may be useful in the treatment, prevention, suppression and amelioration diseases, disorders and conditions such as cancers.

Abstract: In some examples, determining a heart failure status using a medical device comprising one or more sensors includes determining a first value of a heart beat variability metric of a patient while an activity state of a patient satisfies an inactivity criterion based on a signal received from the one or more sensors, and determining, within a predetermined period of time after further determining that the activity state of the patient no longer satisfies the inactivity criterion, a second value of the heart beat variability metric while the activity state of the patient no longer satisfies the inactivity criterion based on the signal. A difference between the first value of the heart beat variability metric and the second value of the heart beat variability metric may be determined and the heart failure status of the patient may be determined based on the difference.

Abstract: An aerosol provision cartridge (30) for an aerosol provision system (10). The cartridge (30) comprises a refillable chamber (100) for aerosol precursor material, the chamber (100) comprising a first opening (102) and a second opening (104), each opening (102;104) allowing for access into the chamber (100). Each opening (102;104) is covered by a respective cap (130;132) which is configured to be uncoupled from the chamber (100) for allowing access to the opening (102;104). The cartridge (30) is configured such that each cap (130;132), when coupled to the chamber (100), requires at least two different actions (A1;A2) to be uncoupled from the chamber (100). The first or second action (A1;A2) may each include, but are not limited, to: rotating; pulling; pushing; or unlatching.

Abstract: A rotor blade for a rotary wing aircraft includes a leading edge and a trailing edge defining a chordwise direction. The leading edge defines a forward end of the rotor blade and the trailing edge defines an aft end of the rotor blade. The rotor blade has a center of gravity and an aerodynamic center along the chordwise direction. The center of gravity is aft of the aerodynamic center.

Abstract: Described herein is a composition for use in a device for generating an inhalable medium, the composition comprising (i) 50-85% by weight of air-cured and/or fire-cured tobacco (ii) 0-50% by weight of flue-cured and/or sun-cured tobacco that has not been subjected to any further treatment which affects the flavor properties of tobacco, and (iii) 0-50% by weight of flue-cured and/or sun-cured tobacco that has been further treated to enhance the flavor properties of tobacco.

Abstract: Techniques are disclosed, using one or more computers. for bidding on digital advertising space associated with media content on a digital platform. Popularity is determined of a plurality of electronic communication and associated clips on a digital platform. A clip is detected which meets a threshold for approaching an activity level of user activity indicating the popularity of the clip. The clip meeting the threshold is labeled as a non-fungible token (NFT) indicating available digital advertising space associated with the clip. In response to the labeling of the clip, monetary bidding is received, based on the NFT by entities buying digital advertising space for digital advertising content associated with the NFT.

Abstract: Agents, kits, and methods that utilize oxygenation to prevent and/or treat intestinal inflammation and/or infections caused by anaerobic microorganisms are provided. In several embodiments, the formulations are provided as a capsule within a capsule in order to separate an oxygen prodrug from a catalyst until the formulation is at a target site within the intestine. In several embodiments, the catalyst is provided in an excess of the oxygen prodrug. In several embodiments, the prodrug is within an inner capsule or coating and a biological material comprising a catalyst (e.g., yeast, spirulina, chlorella, etc.) surrounds the encapsulated prodrug and the biological material is within a capsule or coating. The agents, kits, and methods can be utilized to prevent and/or treat anaerobic bacterial infections of the intestinal lumen by enteric aerobization therapy.

Abstract: A safety plug for use in a bore hole comprising a bore wall. The safety plug comprises a body having a leading end and a trailing end, and at least one flared portion. An anchoring element extends at least partially around an associated flared portion. Axially displacement of anchoring element relative to its associated flared portion causes the anchoring element to bear against the flared portion and transitions the anchoring element between an unexpanded condition and an expanded condition. A nose, comprising conical elements, extends longitudinally from the leading end of body. The nose is longitudinally compressible.

Abstract: A voltage regulator circuit using predictively precharged voltage rails is generally disclosed. For example, the voltage regulator circuit may include a main switching regulator configured to provide a target voltage, the main switching regulator having a first voltage node, a precharge switching regulator configured to provide a precharge voltage, the precharge switching regulator having a second voltage node, the precharge voltage based on a difference between the target voltage and a next target voltage to be provided by the main switching regulator, and a precharge switch circuit configured to selectively couple the second voltage node to an output voltage node based upon a transition from the target voltage to the next target voltage.

Abstract: An additive-manufacturing system for printing spinal implants in-situ, within a patient, is disclosed. The system may include a robotic subsystem having scanning and imaging equipment and an armature including at least one dispensing nozzle and a controller apparatus having a processor and a non-transitory computer-readable medium. The controller may control the scanning and imaging equipment to determine a target alignment of a patients spine, develop an in-situ-printing plan including an in-situ material selection plan based on the target alignment of the patients spine, an interbody access space, and a disc space between adjacent vertebra of the patients spine, and execute the in-situ-printing plan. The controller may further control the armature to dispense at least one material chosen from a rigid material and a pliable material to form at least one motion-sparing implant.

Abstract: Various measures to preserve privacy and to train neural network models are provided. A federated learning system comprises a payment decisioning server associated with a payment decisioning entity and a financial institution server associated with a financial institution. A transaction involves a customer of the financial institution. In an example method, the payment decisioning server transmits, to the financial institution server, a query relating to the customer. In the example method, the payment decisioning server receives, from the financial institution server, a response to the query, the response comprising an account embedding, the account embedding having been derived by the financial institution server using account information associated with the customer as input to a financial institution private embedding model.

Abstract: A control system is provided for a vehicle that includes a plurality of vehicle corner modules (VCMs) which each comprise at least two of: a drive subsystem, a steering subsystem, and a braking subsystem. The control system comprises a network of VCM-controllers that are onboard and installed within a different respective VCM and that are operatively linked to each one of the subsystems of its respective VCM to receive therefrom sensor data and to regulate operation thereof in response to incoming signals received from outside its respective VCM. The control system provides a no-fault operating mode defined by the absence of a control-system fault, and a VCM-controller of a first VCM is programmed to control, when operating in the no-fault operating mode, at least one subsystem in a second VCM.

Abstract: An ergonomic and aerodynamic bicycle handlebar system having appropriate sweep angles and slope angles, embodiments of which can vary both for the type of application and the width of the bar, provides improved energy efficiency, comfort and increased center of gravity control. Flare angle and drop angle can also be adjusted for particular applications. The handlebar may be made of carbon fiber or other suitable materials. Various alternative embodiments are disclosed for drop handlebars and mountain bike handlebars.

Abstract: A system includes a vehicle event recorder and a modem. The vehicle event recorder is configured to receive a sensor data signal from a sensor that is mounted on a vehicle trailer. The modem is configured to demodulate the sensor data signal to create a modulated sensor data signal. The demodulated sensor data signal is received using a first line. The first line is coupled via a harness to sensor on a vehicle trailer.