Abstract: The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.

Abstract: A computerized network links individual lay users, referred to as “standard users,” with qualified professionals in one or more disciplines, such as law, medicine, engineering, accounting and architecture, who are referred to as “participating professionals.” Business entities, such as corporations, partnerships and limited liability companies, can also participate as “enterprise users,” with linkage through the network to both standard users and participating professionals. The network enables standard users, participating professionals and enterprise users to communicate, share information, conduct studies, and negotiate and/or create documents relating to the professional disciplines.

Abstract: Systems and methods are described for optical processing. According to some aspects an apparatus may include a pixelated photodiode array (PDA), wherein each pixel in the PDA includes a radiation detector. The optical processing apparatus may also include a memory that stores one or more characteristics for each pixel in the PDA, and a read out integrated circuit (ROIC) communicatively coupled to the FPA and the memory. In some aspects, the ROIC reads from the memory the one or more characteristics for each pixel in the PDA, and adjusts an arm/disarm bias voltage for each pixel in the PDA based on the one or more characteristics of each pixel.

Abstract: A collet for a tool including an outer nut having a grip and defining a collet bore configured to receive a chuck. The collet bore includes a collet engagement surface engageable with the chuck to selectively secure a tool accessory. The collet also includes a spring having an extension portion engageable with an external part of an output shaft of the tool or an internal part of the outer nut to provide feedback to a user regarding securement of the collet.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

Abstract: The invention relates to methods of production of a silica concentrate from geothermal fluids. More particularly, although not exclusively, the invention relates to the production of a colloidal silica concentrate, colloidal silica or precipitated silica from high temperature geothermal fluids by ultrafiltration to produce size-specific silica colloids and step-wise concentration of silica to avoid precipitation or gelling.

Abstract: A system incenting farmers to improve the environment by removing CO2 from the atmosphere and generating electricity on the same portion of their arable land is disclosed, having a plurality of solar panels installed on at least a portion of a farmer's arable land, prairie grass planted beneath said plurality of solar panels and displacing a crop on the portion of the farmer's arable land, electricity generated by said solar panels either utilized by the farmer or sold to a utility, a computer receiving a signal indicative of the amount of arable land replanted with said prairie grass and the crop displaced, and a carbon offset credit calculated by said computer and owed to the farmer reflecting the amount of CO2 stored by the prairie grass on the farmer's arable land.

Abstract: A computer-implemented method includes receiving process information that specifies one or more process requirements and one or more potential causes of failures associated with processes for manufacturing a design, ii) control information that specifies one or more parameters and one or more values associated with the one or more parameters that facilitate determining whether the one or more process requirements specified in the process information that are associated with the processes are being met, and iii) sensor data associated with the one or more parameters from one or more sensors of a product development environment. Responsive to determining that sensor data associated with a particular parameter of the control information is outside of an associated range of values, a process requirement and a process associated with the parameter is determined based on the process information and the control information.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, in combination with enzyme replacement therapies, as well as methods of making and using the same.

Abstract: Systems and methods are described for optical processing. According to some aspects an apparatus may include a pixelated photodiode array (PDA), wherein each pixel in the PDA includes a radiation detector. The optical processing apparatus may also include a memory that stores one or more characteristics for each pixel in the PDA, and a read out integrated circuit (ROIC) communicatively coupled to the FPA and the memory. In some aspects, the ROIC reads from the memory the one or more characteristics for each pixel in the PDA, and adjusts an arm/disarm bias voltage for each pixel in the PDA based on the one or more characteristics of each pixel.

Abstract: Systems and methods are described for optical processing. According to some aspects an optical processing apparatus may include a pixelated photodiode array (PDA), each pixel in the PDA includes a radiation detector. The apparatus also includes a read out integrated circuit (ROIC) that includes a logic circuit and a plurality of switch elements. The plurality of switch elements being switchable between an armed state for arming its corresponding radiation detector and transmitting a signal received from the corresponding detector to the ROIC, and a disarmed state for disarming its corresponding detector and blocking transmittal of the signal, wherein in the armed state, the PDA is configured to detect an incoming optical signal and in the disarmed state, the PDA is configured to disregard the incoming optical signal. Moreover, the logic circuit controls a switch state of a selectable switch element associated with a radiation detector.

Abstract: A system incentivizing green energy usage is provided having a charging station, an electricity source electrically connected to said charging station, a signal indicative of the sustainability of the electricity source received by said charging station, a mobile electric device receiving electrical charge from said charging station, a signal indicative of electrical charge drawn from the electrical charging station, a signal indicative of usage data for the mobile electric device, the charging station determining pricing based on at least one of the signal indicative of the sustainability of the electricity source, the signal indicative of the electrical charge drawn and the signal indicative of usage data.

Abstract: Systems and methods are provided for controlling infrared radiation (IR) sources of a sauna including tuning IR wavelength-ranges and radiated power-levels of IR sources, and directing IR to locations on a user's body. In one illustrative embodiment, a sauna may be provided having adjustable IR emitters to emit IR at any wavelength resulting in a desirable radiation treatment for the sauna user. In another illustrative embodiment, a method is provided for tuning IR emitters in a sauna.

Abstract: Disclosed herein are engineered cell-based peptide delivery platforms based on T cells lacking Perforin function. Perforin-null T cells lack cytotoxic effector function and thus are not capable of killing target cells by conventional Perforin dependent pathways. However, they efficiently home to target tissues where they can invade, persist, and proliferate. The homing ability of perforin lacking T cells can therefore be used to deliver anti-cancer or pre-immune peptides to tumors, or therapeutic peptides to other target tissues based on antigen recognition. Because the cells lack cytotoxic effector function due to loss, knockdown, or inhibition of Perforin, they can be targeted to tissues based on antigen recognition without destroying the target tissue directly.

Abstract: A programmable and universal video platform enabling digital ads from ad sales teams, online digital exchanges, demand side platforms or other digital video advertising aggregators, to be inserted into linear television cable programming feeds.

Abstract: A system for developing machine learning for use in the radiofrequency domain that produces a robust set of training data for machine learning from a small set of labelled training data that is bootstrapped with unlabeled electromagnetic environment data. A raw signal set is prepared from the labeled data and separately processed for any electromagnetic environment and interference signals as well as for a primary signal by applying the real electromagnetic environment data and then summed to generate a second data set that is larger than the first data set. Feature extraction is used to produce a bootstrapped labelled data set that is larger than the original labelled data set and that can be used as training data for machine language classification.

Abstract: A system for training a domesticated animal includes a platform having a detector for generating a signal corresponding to performance of a predetermined behavior by the animal, wherein the signal is transmitted to a controller. Upon the animal performing the predetermined behavior for a predetermined period of time, the controller generates a feedback indicator to the animal and a caretaker message to a caretaker.

Abstract: Organodifluorine synthons, in conjunction with three-component diastereoselective Anion Relay Chemistry (ARC), permit ready access to diverse difluoromethylene scaffolds. Initiated via [1,2]-addition of an organolithium reagent to a ?-difluoromethylene silyl aldehyde, an alkoxide intermediate is formed, which is capable of undergoing a [1,4]-Brook rearrangement to generate a stabilized ?-difluoromethylene carbanion, which upon electrophile capture, affords a three-component adduct. This three-component synthetic tactic represents an important one-pot divergent strategy for the construction of diverse organodifluorine containing compounds.

Abstract: Disclosed herein are compositions and methods for manufacturing composite paper-based sorbents configured for durability, and high surface area exposure to air. Composite paper-based sorbents can comprise fibers (e.g. natural and/or synthetic fibers), anion exchange resins, and additives. Composite paper-based sorbents can be configured for durability when used in various forming processes, e.g., corrugation, and when used under a variety of conditions, for example, in high and low humidity environments.

Abstract: Methods and systems are described for assessing a computer network using a graph model. In some instances, the methods comprise: receiving data from at least one data stream of a plurality of data streams, wherein the plurality of data streams comprise computer network data provided by one or more data brokers, and wherein the data received from different data streams of the plurality comprise different data formats; converting the data received from the at least one data stream to a common data format comprising a node or an edge; updating a graph model comprising a plurality of nodes and edges stored within a graph database according to the node or edge of the converted data; and providing a user of the computer network with a visualization of a status of the computer network.