Abstract: The present disclosure relates to a structure which includes a merged write driver circuit with a first device next to a first memory array and a second device next to a second memory array, and the merged write driver circuit being configured to share a write driver line between the first device and the second device.

Abstract: The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.

Abstract: Methods are disclosed for treating and/or preventing retinal degeneration is a subject. In some embodiments, the method includes administering to the subject a therapeutically effective amount of a selective estrogen receptor modulator (SERM) to treat the retinal degeneration in the subject. In other embodiments, the SERM is administered orally. In some examples, the SERM is tamoxifen, afimoxifene, raloxifene, bazedoxifene, arzoxifene, desmethylarzoxifene, or a salt or derivative thereof, or combinations thereof.

Abstract: The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.

Abstract: A method, article of manufacture, and system for cloud backups is discussed. Heterogeneous backup appliances may be deployed in a datacenter. Facades may interface these appliances with a backup management system.

Abstract: A positioning system is provided in which a client device samples a transmission from any suitable terrestrial wireless source. The resulting samples are correlated with replica samples to determine a position of the client device using time-difference-of-arrival-based calculations.

Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.

Abstract: Embodiments described herein provide approaches for validating synonyms in ontology driven natural language processing. Specifically, an approach is provided for receiving a user input containing a token, structuring the user input into a semantic model comprising a set of classes each containing a set of related permutations of the token, designating the token as a synonym of one of the set of related permutations, annotating the token with a class from the set of classes corresponding to the one of the set of related permutations, and validating the annotation of the token by determining an accuracy of the designation of the token as a synonym of the one of the set of related permutations. In one embodiment, the accuracy is determined by quantifying a linear distance between the token and a contextual token also within the user input, and comparing the linear distance to a pre-specified linear distance limit.

Abstract: Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.

Abstract: A system, method and computer program product to validate documents is provided. A processor receives an image of a document. The processor identifies a plurality of fixed contents of the document. The processor identifies a plurality of field contents of the document. The processor determines a type of the document based, at least in part, on the plurality of fixed contents and the plurality of field contents. The processor validates the plurality of field contents of the document based, at least in part, on rules associated with the type of the document. The processor generates a validated document.

Abstract: Embodiments described herein provide approaches for validating synonyms in ontology driven natural language processing. Specifically, an approach is provided for receiving a user input containing a token, structuring the user input into a semantic model comprising a set of classes each containing a set of related permutations of the token, designating the token as a synonym of one of the set of related permutations, annotating the token with a class from the set of classes corresponding to the one of the set of related permutations, and validating the annotation of the token by determining an accuracy of the designation of the token as a synonym of the one of the set of related permutations. In one embodiment, the accuracy is determined by quantifying a linear distance between the token and a contextual token also within the user input, and comparing the linear distance to a pre-specified linear distance limit.

Abstract: The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.

Abstract: A method for estimating the location of a beacon from an ensemble of measurements associated with said beacon, where, contained in each measurement, are GPS data from which surfaces of location may be extracted, together with the ID's of beacons detectable at the point of measurement, is disclosed. The method comprises extracting the canonical set of surfaces of location implicit in each of the associated measurements, and determining the estimate of the location of the beacon as the point for which a weighted sum of the squares of the distances to each of the surfaces so extracted is minimized. A system for the compilation of a database of beacon locations from measurements containing a time-stamped recording of the composite GPS signal (which recording is referred to as a datagram), together with the ID's and associated signal strengths of beacons detectable at the point of measurement, is also disclosed.

Abstract: The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.

Abstract: A universal serial bus (USB) charger provides power to a client device. A USB connector interfaces with a client device and receives a request for the output voltage of the USB charger to be at a specific value. If the requested voltage level is lower than the current output voltage level, the output voltage level is set to the requested level and a bleeder circuit is enabled to discharge the output capacitor of the USB charger.

Abstract: Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.

Abstract: Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: A system, method and computer program product to validate documents is provided. A processor receives an image of a document. The processor identifies a plurality of fixed contents of the document. The processor identifies a plurality of field contents of the document. The processor determines a type of the document based, at least in part, on the plurality of fixed contents and the plurality of field contents. The processor validates the plurality of field contents of the document based, at least in part, on rules associated with the type of the document. The processor generates a validated document.

Abstract: Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.