Abstract: Embodiments described herein provide approaches for validating synonyms in ontology driven natural language processing. Specifically, an approach is provided for receiving a user input containing a token, structuring the user input into a semantic model comprising a set of classes each containing a set of related permutations of the token, designating the token as a synonym of one of the set of related permutations, annotating the token with a class from the set of classes corresponding to the one of the set of related permutations, and validating the annotation of the token by determining an accuracy of the designation of the token as a synonym of the one of the set of related permutations. In one embodiment, the accuracy is determined by quantifying a linear distance between the token and a contextual token also within the user input, and comparing the linear distance to a pre-specified linear distance limit.

Abstract: The present invention relates to the identification of pancreatic cancer biomarkers for the detection of early pancreatic cancer. The present invention also provides methods of diagnosing pancreatic cancer and distinguishing between pancreatic cancer and chronic pancreatitis. The present invention additionally provides kits that find use in the practice of the methods of the invention.

Abstract: A method for estimating the location of a beacon from an ensemble of measurements associated with said beacon, where, contained in each measurement, are GPS data from which surfaces of location may be extracted, together with the ID's of beacons detectable at the point of measurement, is disclosed. The method comprises extracting the canonical set of surfaces of location implicit in each of the associated measurements, and determining the estimate of the location of the beacon as the point for which a weighted sum of the squares of the distances to each of the surfaces so extracted is minimized. A system for the compilation of a database of beacon locations from measurements containing a time-stamped recording of the composite GPS signal (which recording is referred to as a datagram), together with the ID's and associated signal strengths of beacons detectable at the point of measurement, is also disclosed.

Abstract: The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.

Abstract: A universal serial bus (USB) charger provides power to a client device. A USB connector interfaces with a client device and receives a request for the output voltage of the USB charger to be at a specific value. If the requested voltage level is lower than the current output voltage level, the output voltage level is set to the requested level and a bleeder circuit is enabled to discharge the output capacitor of the USB charger.

Abstract: Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.

Abstract: Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: A system, method and computer program product to validate documents is provided. A processor receives an image of a document. The processor identifies a plurality of fixed contents of the document. The processor identifies a plurality of field contents of the document. The processor determines a type of the document based, at least in part, on the plurality of fixed contents and the plurality of field contents. The processor validates the plurality of field contents of the document based, at least in part, on rules associated with the type of the document. The processor generates a validated document.

Abstract: Disclosed herein are biomarkers related to gastric cancer. The presently identified salivary biomarkers create the basis for a gastric cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed gastric cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: A system, method and computer program product to validate documents is provided. A processor receives an image of a document. The processor identifies a plurality of fixed contents of the document. The processor identifies a plurality of field contents of the document. The processor determines a type of the document based, at least in part, on the plurality of fixed contents and the plurality of field contents. The processor validates the plurality of field contents of the document based, at least in part, on rules associated with the type of the document. The processor generates a validated document.

Abstract: The molecules harbored in exosomes play important roles in biological science. A highly desirable goal for exosome research is the rapid, simple, simultaneous tracking and quantification of exosome harbored molecules. Disclosed herein are methods and devices for inducing the release and measurement of biomolecules harbored in exosomes. The disclosed method, Electric Field Induced Release and Measurement (EFIRM) technique, uses an electrical field to simultaneously disrupt exosomes to release the contents and measure the harbored exosomal RNA/proteins. The exosome vesicle contents can be released within minutes. This provides a potential on-site method for the detection of exosome-harbored biomolecules.

Abstract: A method of non-destructive inspection evaluation includes converting a scan file of a part into a text file, determining whether the signal attenuation representative value is greater than a predetermined value and outputting a numeric score related to the signal attenuation representative value to signify a defect.

Abstract: A power converter with a dynamic preload. The power converter includes a magnetic component coupled between an input and an output of the power converter. The output of the power converter has an output voltage for providing power to a load. A switch is adapted to control current through the magnetic component according to on and off times of the switch. A dynamic preload circuit is coupled to the output of the power converter. The dynamic preload has loading characteristics that are adjusted responsive to a signal indicative of an output voltage at the output of the power converter.

Abstract: A positioning system is provided in which a client device samples a transmission from any suitable terrestrial wireless source. The resulting samples are correlated with replica samples to determine a position of the client device using time-difference-of-arrival-based calculations.

Abstract: Presented herein are biomarkers related to lung cancer. The presently identified salivary biomarkers create the basis for a lung cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed lung cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: Presented herein are biomarkers related to breast cancer. The presently identified salivary biomarkers create the basis for a breast cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed breast cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: To recombine incorrectly separated tokens in NLP, a determination is made whether a token from an ordered set of tokens is present in a dictionary related to a corpus from which the ordered set is extracted. When the token is not present in the dictionary, and when a compounding threshold has not been reached, the token is agglutinated with a next adjacent token in the ordered set to form the compound token. The compounding threshold limits a number of tokens that can be agglutinated to form a compound token. A determination is made whether the compound token is present in the dictionary. A weight is assigned to the compound token when the compound token is present in the dictionary and a confidence rating of the compound token is computed as a function of the weight. The compound token and the confidence rating are used in NLP of the corpus.

Abstract: Presented herein are biomarkers related to lung cancer. The presently identified salivary biomarkers create the basis for a lung cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed lung cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: Presented herein are biomarkers related to breast cancer. The presently identified salivary biomarkers create the basis for a breast cancer detection bioassay with sensitivity and specificity. Means and methods for evaluating the data generated using multiple biomarkers in order to validate findings and further use of the multiplexed breast cancer assay in clinical, diagnostic and therapeutic uses is also included.

Abstract: A lighting system includes at least one lighting apparatus having a light emitting element capable of emitting a controllably variable light output in a region. A position determination subsystem is capable of determining a position in three dimensions of at least one mobile entity within the region. A control subsystem is capable of variably controlling a light output of the at least one lighting apparatus according to the position of the mobile entity. The system may determine position by radio ranging with mobile electronic elements. The system may include multiple lighting elements and may determine light levels according to positions of multiple mobile entities. The system may include a database of information about lighting elements, mobile entities, and lighting plans that may be selected from mobile electronic elements.