Abstract: The present invention relates to a method for mass purifying high-purity bacterial extracellular vesicles and, more specifically, the present invention relates to a method for quickly and conveniently isolating and purifying high-purity bacterial extracellular vesicles from a large amount of bacterial cell culture product by means of calcium or cobalt. The purification method of the present invention is appropriate for obtaining high-purity bacterial extracellular vesicles in a commercial scale by treating a large amount of bacterial cell culture product and, particularly, when using calcium which is innocuous to the human body, is more advantageous in purifying bacterial extracellular vesicles to be used in a drug for human body.

Abstract: A battery sub-packing unit includes at least one battery cell; and a case accommodating the at least one battery cell, wherein the case comprises an end panel on which an electrode tab of the at least one battery cell is fastened to extend into an external space, and having a lower end portion in which a sub-vent hole is formed for communication between the external space and an internal space in which the at least one battery cell is disposed.

Abstract: The present specification relates to an adamantanecarboxylic acid benzyl amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, and a skin whitening composition comprising the same as an active ingredient. Specifically, the compound, according to the present specification, is a compound having a novel structure having adamantanecarboxylic acid bound to an amine compound, and exhibits a skin whitening effect by inhibiting the production of melanin, and thus may be used in various ways as a pharmaceutical composition, a cosmetic composition or a skin preparation for external use.

Abstract: A sensor for measuring a temperature change amount. The sensor includes a first composite material layer including a polymer having a volume changing according to a temperature change amount; an electrode layer provided on one side of the first composite material layer and capable of representing the temperature change amount as a resistance change amount; and a second composite material layer at least partially provided on the upper side of the first composite material layer and containing polydimethylsiloxane (PDMS) and at least one of carbon nanotubes (CNT), boron nitride nanotubes (BNNT), and graphene or containing a thermoplastic polyurethane (TPU) so that the temperature change occurring on one side thereof is transferred to the other side thereof.

Abstract: The present specification discloses an immunomodulatory composition comprising lactobacillus-derived extracellular vesicles as an active ingredient. The lactobacillus may be Lactobacillus plantarum. The composition has the effects of inducing differentiation into M2-type macrophages and reducing expression of at least one member selected from the group consisting of CCR2, SOCS3 and HLA-DR?, which are M1-type macrophage differentiation markers.

Abstract: A cosmetic composition includes a compound of the following chemical formula as an active ingredient. A method for regenerating skin includes applying an effective amount of the cosmetic composition to skin: wherein R1 to R7 are independently a substituted or unsubstituted C1 to C20 alkyl group.

Abstract: Disclosed is a composition including a Hibiscus syriacus extract as an effective ingredient for treating fine dust-caused skin damage, wherein the expression of at least one selected from the group consisting of IL-36G (NM_019618), PTGS2 (NM_000963), XDH (NM_000379) and S100A7 (NM_002963), which are all genes having the expression levels affected by fine dust in skin cells, is regulated to a normal level and for inhibiting an antibacterial peptide, wherein the expression of the antibacterial peptide S100A7 (NM_002963) is regulated to a normal level. By using the composition for treating fine dust-caused skin damage and the composition for inhibiting an antibacterial peptide, gene expression changed by fine dust can return to a normal level to treat skin cell damage and the increased expression of the antibacterial peptide due to various causes can return to normal level.

Abstract: The present specification relates to an adamantanecarboxylic acid benzyl amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, and a skin whitening composition comprising the same as an active ingredient. Specifically, the compound, according to the present specification, is a compound having a novel structure having adamantanecarboxylic acid bound to an amine compound, and exhibits a skin whitening effect by inhibiting the production of melanin, and thus may be used in various ways as a pharmaceutical composition, a cosmetic composition or a skin preparation for external use.

Abstract: Provided are a composition including a compound of the following chemical formula as an active ingredient and a method of inhibiting a cortisone reductase by applying the same:

Abstract: Provided are a composition including a compound of the following chemical formula as an active ingredient and a method of strengthening the skin barrier by applying it to skin of a subject:

Abstract: Provided are a composition including coumestrol extracted from soybeans as an active ingredient, and a method of inhibiting cortisone reductase by applying it to skin of a subject.

Abstract: Provided are a composition including a compound of the following chemical formula as an active ingredient, and a method of enhancing a skin barrier by applying it to the skin:

Abstract: A skin external composition containing 1,2,3,4,6-penta-O-galloyl-?-D-glucose (hereinafter referred to as “PGG”) and its use to improve moisture balance of skin are disclosed. The skin external composition, due to containing PGG, stimulates the formation of filaggrin in keratinocytes, increases loricrin and involucrin expression, thereby stimulating the formation of a normal keratin layer, and as a result, can strengthen the skin barrier function to provide an excellent skin moisturization improving effect. Thus, the composition is effective in improving moisture balance of skin. A method for moisturizing the skin using the composition is also disclosed.

Abstract: Provided is a composition for inhibiting cortisone reductase, including a compound represented by a specific chemical formula as an active ingredient.

Abstract: Provided are a composition including a compound represented by a specific chemical formula as an active ingredient and a method of inhibiting a cortisone reductase by applying the same to skin of a subject.

Abstract: A cosmetic composition includes a compound of the following chemical formula as an active ingredient. A method for regenerating skin includes applying an effective amount of the cosmetic composition to skin: wherein R1 to R7 are independently a substituted or unsubstituted C1 to C20 alkyl group.

Abstract: One aspect of the present disclosure relates to a composition for enhancing the skin barrier containing Abies sibirica oil as an active ingredient, wherein Abies sibirica oil reacts with the fragrance receptor OR6M1 present in epidermal cells to enhance the skin barrier, restore the damaged skin barriers and enhance the skin moisturizing.

Abstract: The present specification discloses an immunomodulatory composition comprising Lactobacillus-derived extracellular vesicles as an active ingredient. The Lactobacillus may be Lactobacillus plantarum. The composition has the effects of inducing differentiation into M2-type macrophages and reducing expression of at least one member selected from the group consisting of CCR2, SOCS3 and HLA-DR?, which are M1-type macrophage differentiation markers.

Abstract: Disclosed is a novel use of a composition comprising as an active ingredient an Artemisia umbelliformis extract. A composition according to the present description shows hair follicle cell proliferation or hair growth effect by means of comprising an Artemisia umbelliformis extract. Therefore, due to said effect, the Artemisia umbelliformis extract has hair loss prevention or hair growth stimulation effect.

Abstract: One aspect of the present disclosure relates to a gardenia red pigment stably adsorbed on the surface of silica, and a cosmetic composition containing the same, and more specifically, to a gardenia red pigment stably adsorbed on the surface of silica, the silica surface having a specific reactive group introduced thereto, and a cosmetic composition containing the same. Compared to conventional gardenia red pigments, the gardenia red pigment stably adsorbed on the surface of silica, according to one aspect of the present disclosure, has improved thermal stability, does not aggregate at a low pH level, and may be applied to cosmetic compositions other than water-phase cosmetic compositions, and thus can have a further expanded range of use.