Patents by Inventor Takaaki Hagiwara
Takaaki Hagiwara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959914Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: GrantFiled: January 29, 2019Date of Patent: April 16, 2024Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Tatsuki Takakura, Kenta Imai, Takaaki Hagiwara, Yoshihiro Yamashita, Taku Sakazume, Beatus Ofenloch-Haehnle, Michaela Windfuhr, Ursula Pauselius-Fuchs, Rita Haerteis
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Patent number: 11913372Abstract: This turbocharger includes: an impeller which includes a hub provided to be rotatable around a center axis and a plurality of turbine blades arranged on the outside of the hub in a radial direction at intervals in a circumferential direction around the center axis; and a turbine housing which is disposed on the outside of the impeller in the radial direction and forms a scroll flow path guiding an exhaust gas toward the impeller on the inside of the radial direction while turning the exhaust gas in the circumferential direction, wherein a flow path width in the circumferential direction of at least one of a plurality of inter-blade flow path portions formed between the plurality of turbine blades is different from a flow path width of the another of the plurality of inter-blade flow path portions.Type: GrantFiled: November 25, 2020Date of Patent: February 27, 2024Assignee: MITSUBISHI HEAVY INDUSTRIES ENGINE & TURBOCHARGER, LTD.Inventors: Toru Hoshi, Yukihide Nagayo, Shoeji Nakaye, Toshikazu Mori, Takaaki Hagiwara
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Patent number: 11740254Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.Type: GrantFiled: November 29, 2018Date of Patent: August 29, 2023Assignees: Hitachi High-Tech Corporation, Roche Diagnostics Operations, Inc.Inventors: Yuichiro Ota, Takaaki Hagiwara, Yoshihiro Yamashita, Koshin Hamasaki, Michaela Windfuhr, Heike Guggemos, Johannes Stoeckel, Guenter Ziegler, Michael Kuehnl
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Publication number: 20230265783Abstract: This turbocharger includes: an impeller which includes a hub provided to be rotatable around a center axis and a plurality of turbine blades arranged on the outside of the hub in a radial direction at intervals in a circumferential direction around the center axis; and a turbine housing which is disposed on the outside of the impeller in the radial direction and forms a scroll flow path guiding an exhaust gas toward the impeller on the inside of the radial direction while turning the exhaust gas in the circumferential direction, wherein a flow path width in the circumferential direction of at least one of a plurality of inter-blade flow path portions formed between the plurality of turbine blades is different from a flow path width of the another of the plurality of inter-blade flow path portions.Type: ApplicationFiled: November 25, 2020Publication date: August 24, 2023Applicant: MITSUBISHI HEAVY INDUSTRIES ENGINE & TURBOCHARGER, LTD.Inventors: Toru HOSHI, Yukihide NAGAYO, Shoeji NAKAYE, Toshikazu MORI, Takaaki HAGIWARA
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Publication number: 20220221477Abstract: Proposed is a technique for facilitating work of cause investigation of a defect by an operator. The present disclosure proposes an automatic analyzer including: a reagent dispensing unit configured to aspirate a reagent from a reagent vessel that contains the reagent, and discharge the reagent into a reaction vessel that contains a reaction liquid containing a sample; a storage unit configured to store a type of the sample and concentration-related information determined for each type of the sample and related to a concentration of a component to be measured contained in the sample; a detection unit configured to detect a measurement concentration that is the concentration of the component to be measured contained in the reaction liquid; and a determination unit configured to determine whether an abnormality occurs in the reagent vessel based on the concentration-related information and the measurement concentration.Type: ApplicationFiled: March 3, 2020Publication date: July 14, 2022Inventors: Hirobumi SHIOHATA, Yuichiro OTA, Takaaki HAGIWARA
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Publication number: 20220011326Abstract: In a case where plural measurement items that require different incubation times are simultaneously measured in an automatic analyzer, deterioration of the turnaround time of the measurement is minimized. The automatic analyzer receives a request of a sample, obtains a ratio of a short measurement item among examination items of the received analysis request, and a determines an empty cycle based on the ratio of the short measurement item and the number of schedules. When an empty cycle is necessary, the empty cycle is scheduled in a schedule of a sample that is requested to be measured first, for example, an empty cycle in a short measurement for making an incubator empty. As a result, this position can be used for a measurement of a short measurement item such that the wait time of the start of the measurement can be short.Type: ApplicationFiled: July 3, 2019Publication date: January 13, 2022Inventors: Takaaki HAGIWARA, Teruhiro YAMANO, Kazunori YAMAZAWA, Taku SAKAZUME
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Patent number: 10921337Abstract: The purpose of the present invention is to provide an automatic analyzing device capable of carrying in/out a reagent suitable for the intended use of a user according to the state of the device. An automatic analyzing device has a reagent refrigerator for movably holding reagent containers and a reagent loader for carrying in/out the reagent containers to/from the reagent refrigerator through movement in a direction perpendicular to the reagent refrigerator. A reagent refrigerator cover covers an upper surface of the reagent refrigerator and has an opening through which the reagent loader can pass. A storage unit stores a device state of the automatic analyzing device and a reagent-carry-in/out-method is selected on the basis of the device state. A control unit controls the reagent holder and the reagent loader according to the selected reagent carry-in/out method so as to carry in/out a target reagent container.Type: GrantFiled: May 25, 2016Date of Patent: February 16, 2021Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Hiroki Fujita, Toshiharu Suzuki, Takaaki Hagiwara
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Publication number: 20200240981Abstract: The automatic analyzer includes: a sample dispensing unit that dispenses a sample into a reaction vessel; a reagent dispensing unit that dispenses a reagent into the reaction vessel; a control unit that controls the sample dispensing unit and the reagent dispensing unit; and a measurement unit that measures a mixed solution of the sample and the reagent mixed in the reaction vessel. The reagent includes three types of reagents of: a first reagent that specifically binds to an antigen in the sample; a second reagent that specifically binds to a site different from that to which the first reagent binds with respect to the antigen and has a label to be detected by the measurement unit; and a third reagent that specifically binds to a site different from the binding site of the first reagent and the antigen and contains insoluble carriers.Type: ApplicationFiled: January 29, 2019Publication date: July 30, 2020Inventors: Tatsuki TAKAKURA, Kenta IMAI, Takaaki HAGIWARA, Yoshihiro YAMASHITA, Taku SAKAZUME, Beatus OFENLOCH-HAEHNLE, Michaela WINDFUHR, Ursula PAUSELIUS-FUCHS, Rita HAERTEIS
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Publication number: 20200209273Abstract: The object of the invention is to provide an automatic analysis apparatus capable of setting a dispensing mechanism for measuring dispensing accuracy and a dispensing volume, and capable of performing dispensing accuracy measurement without absorbance measurement. Regarding a dispensing accuracy, a dispensing mechanism to be measured is designated. Parameters including a dispensing volume and the like are input. A dispensing operation of the input dispensing volume is automatically performed for each designated dispensing mechanism. A reaction vessel contains, for example, a reagent of the input dispensing volume which has been dispensed by the designated dispensing mechanism. By measuring a weight of the reagent in the reaction vessel, or the like, it is possible to measure the dispensing accuracy of the designated dispensing mechanism.Type: ApplicationFiled: November 29, 2018Publication date: July 2, 2020Inventors: Yuichiro OTA, Takaaki HAGIWARA, Yoshihiro YAMASHITA, Koshin HAMASAKI, Michaela WINDFUHR, Heike GUGGEMOS, Johannes STOECKEL, Guenter ZIEGLER, Michael KUEHNL
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Patent number: 10012663Abstract: A display unit displays, on a single screen, a first display area configured from a first area corresponding to the position on a reagent disc at which a reagent container is disposed and a second display area configured from a second area corresponding to the position on a reagent loader at which a reagent container is disposed. A control unit changes the display state of the first area on the basis of whether a reagent container is placed at a position on the reagent disk corresponding to the first area and reagent information for the reagent accommodated in the placed reagent container and changes the display state of the second area on the basis of whether a reagent container is placed at a position on the reagent loader corresponding to the second area and reagent-container-conveyance-state information for the placed reagent container.Type: GrantFiled: April 22, 2015Date of Patent: July 3, 2018Assignee: Hitachi High-Technologies CorporationInventors: Takaaki Hagiwara, Toshiharu Suzuki, Hiroki Fujita
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Publication number: 20180180637Abstract: The purpose of the present invention is to provide an automatic analyzing device capable of carrying in/out a reagent suitable for the intended use of a user according to the state of the device. An automatic analyzing device has a reagent refrigerator for movably holding reagent containers and a reagent loader for carrying in/out the reagent containers to/from the reagent refrigerator through movement in a direction perpendicular to the reagent refrigerator. A reagent refrigerator cover covers an upper surface of the reagent refrigerator and has an opening through which the reagent loader can pass. A storage unit stores a device state of the automatic analyzing device and a reagent-carry-in/out-method is selected on the basis of the device state. A control unit controls the reagent holder and the reagent loader according to the selected reagent carry-in/out method so as to carry in/out a target reagent container.Type: ApplicationFiled: May 25, 2016Publication date: June 28, 2018Inventors: Hiroki FUJITA, Toshiharu SUZUKI, Takaaki HAGIWARA
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Patent number: 9977041Abstract: It is determined whether an automatic analysis device is in a state where it is necessary to perform periodic cleaning or periodic replacement on a B/F separation passage of a reaction liquid suction nozzle 120 for B/F separation or the like and a detection passage of a reaction liquid suction nozzle 123 for detection, a detection unit 124, and the like, based on the properties of a specimen, a reagent, and a reaction liquid which is obtained by reacting the specimen and the reagent, an analysis protocol which defines treatment conditions of these solutions, and the number of times of dispensing, feeding, and measuring the solutions; and the determined result is displayed on a display 130 as a signal. Accordingly, the automatic analysis device is provided so as to be able to perform adequate maintenance in accordance with analysis conditions.Type: GrantFiled: December 3, 2013Date of Patent: May 22, 2018Assignee: Hitachi High-Technologies CorporationInventors: Yoshihiro Yamashita, Takaaki Hagiwara, Toshiharu Suzuki
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Patent number: 9958468Abstract: The present invention provides an automatic analyzer capable of reducing the time necessary for analysis processing by making various operations pertaining to the analysis processing more efficient. More specifically, the present invention is characterized in that, from among a plurality of ending operation items set as analysis ending operations to perform at the end of analysis operations for analyzing a sample under analysis, one or more ending operation items to be performed are selected, and on the basis of monitoring results of monitoring the status of an automatic analyzer during the period from the end of the analysis ending operations to the start of analysis preparation operations for preparing for the analysis operations, one or more preparation operation items to be performed are selected from among a plurality of preparation operation items set as analysis preparation operations.Type: GrantFiled: July 25, 2014Date of Patent: May 1, 2018Assignee: Hitachi High-Technologies CorporationInventors: Yoshihiro Yamashita, Toshiharu Suzuki, Takaaki Hagiwara, Kazunori Yamazawa
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Publication number: 20170205435Abstract: A display unit displays, on a single screen, a first display area configured from a first area corresponding to the position on a reagent disc at which a reagent container is disposed and a second display area configured from a second area corresponding to the position on a reagent loader at which a reagent container is disposed. A control unit changes the display state of the first area on the basis of whether a reagent container is placed at a position on the reagent disk corresponding to the first area and reagent information for the reagent accommodated in the placed reagent container and changes the display state of the second area on the basis of whether a reagent container is placed at a position on the reagent loader corresponding to the second area and reagent-container-conveyance-state information for the placed reagent container.Type: ApplicationFiled: April 22, 2015Publication date: July 20, 2017Inventors: Takaaki HAGIWARA, Toshiharu SUZUKI, Hiroki FUJITA
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Patent number: 9709587Abstract: An automatic analyzer is capable of performing a preparation process on a reagent used to measure a highly urgent test item even during analysis operation, and is configured as follows. If there is no parameter for the analysis item regarding a new reagent, the parameters are downloaded. If the priority of reagent preparation is “high,” a sample pipetting scheduling process is temporarily stopped. If the priority of reagent preparation is not “high,” it is determined whether a waiting time limit has been exceeded, and if it has, the sample pipetting scheduling process is stopped temporarily, reagent preparation scheduling is performed, and the sample pipetting scheduling process is resumed. If it is determined that the waiting time limit has not been exceeded, if the priority of reagent preparation is “medium,” and if the reagent preparation mechanism is found available, then reagent preparation scheduling is performed.Type: GrantFiled: December 26, 2012Date of Patent: July 18, 2017Assignee: Hitachi High-Technologies CorporationInventors: Takaaki Hagiwara, Kazunori Yamazawa, Hiroki Fujita
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Patent number: 9494611Abstract: An automatic analyzer comprises selection means for selecting whether a preparatory operation, specified from a plurality of analysis preparation processes of the automatic analyzer, should be executed in an initial process at the powering on of the analyzer or after the start of the actual analysis (i.e., in parallel with the sample analysis operation). For example, the automatic analyzer is equipped with means which allows the analyzer to execute a “system liquid replacement operation”, a “sample nozzle pressure sensor checking operation”, a “reaction vessel discarding operation” and a “pre-cleaning liquid replacement operation” which among various operations that are executed in the preparation process in conventional immunological analyzing apparatus in processes other than the preparation process.Type: GrantFiled: April 3, 2015Date of Patent: November 15, 2016Assignee: Hitachi High-Technologies CorporationInventors: Takaaki Hagiwara, Yoshiyuki Tanaka, Kazunori Yamazawa
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Publication number: 20160154016Abstract: The present invention provides an automatic analyzer capable of reducing the time necessary for analysis processing by making various operations pertaining to the analysis processing more efficient. More specifically, the present invention is characterized in that, from among a plurality of ending operation items set as analysis ending operations to perform at the end of analysis operations for analyzing a sample under analysis, one or more ending operation items to be performed are selected, and on the basis of monitoring results of monitoring the status of an automatic analyzer during the period from the end of the analysis ending operations to the start of analysis preparation operations for preparing for the analysis operations, one or more preparation operation items to be performed are selected from among a plurality of preparation operation items set as analysis preparation operations.Type: ApplicationFiled: July 25, 2014Publication date: June 2, 2016Inventors: Yoshihiro YAMASHITA, Toshiharu SUZUKI, Takaaki HAGIWARA, Kazunori YAMAZAWA
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Publication number: 20150293135Abstract: It is determined whether an automatic analysis device is in a state where it is necessary to perform periodic cleaning or periodic replacement on a B/F separation passage of a reaction liquid suction nozzle 120 for B/F separation or the like and a detection passage of a reaction liquid suction nozzle 123 for detection, a detection unit 124, and the like, based on the properties of a specimen, a reagent, and a reaction liquid which is obtained by reacting the specimen and the reagent, an analysis protocol which defines treatment conditions of these solutions, and the number of times of dispensing, feeding, and measuring the solutions; and the determined result is displayed on a display 130 as a signal. Accordingly, the automatic analysis device is provided so as to be able to perform adequate maintenance in accordance with analysis conditions.Type: ApplicationFiled: December 3, 2013Publication date: October 15, 2015Inventors: Yoshihiro Yamashita, Takaaki Hagiwara, Toshiharu Suzuki
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Publication number: 20150212102Abstract: An automatic analyzer comprises selection means for selecting whether a preparatory operation, specified from a plurality of analysis preparation processes of the automatic analyzer, should be executed in an initial process at the powering on of the analyzer or after the start of the actual analysis (i.e., in parallel with the sample analysis operation). For example, the automatic analyzer is equipped with means which allows the analyzer to execute a “system liquid replacement operation”, a “sample nozzle pressure sensor checking operation”, a “reaction vessel discarding operation” and a “pre-cleaning liquid replacement operation” which among various operations that are executed in the preparation process in conventional immunological analyzing apparatus in processes other than the preparation process.Type: ApplicationFiled: April 3, 2015Publication date: July 30, 2015Inventors: Takaaki HAGIWARA, Yoshiyuki TANAKA, Kazunori YAMAZAWA
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Publication number: 20140356233Abstract: An automatic analyzer is capable of performing a preparation process on a reagent used to measure a highly urgent test item even during analysis operation, and is configured as follows. If there is no parameter for the analysis item regarding a new reagent, the parameters are downloaded. If the priority of reagent preparation is “high,” a sample pipetting scheduling process is temporarily stopped. If the priority of reagent preparation is not “high,” it is determined whether a waiting time limit has been exceeded, and if it has, the sample pipetting scheduling process is stopped temporarily, reagent preparation scheduling is performed, and the sample pipetting scheduling process is resumed. If it is determined that the waiting time limit has not been exceeded, if the priority of reagent preparation is “medium,” and if the reagent preparation mechanism is found available, then reagent preparation scheduling is performed.Type: ApplicationFiled: December 26, 2012Publication date: December 4, 2014Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Takaaki Hagiwara, Kazunori Yamazawa, Hiroki Fujita