Patents by Inventor Takao Isogai
Takao Isogai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070020637Abstract: Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: ApplicationFiled: January 21, 2004Publication date: January 25, 2007Inventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Al Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Junichi Yamamoto, Yuko Isono, Keiichi Nagai, Ryotaro Irie
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Publication number: 20070015163Abstract: Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: ApplicationFiled: June 27, 2005Publication date: January 18, 2007Inventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Ai Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Jun-ichi Yamamoto, Yuuko Isono, Yuri Hio, Kaoru Otsuka, Keiichi Nagai, Ryotaro Irie, Ichiro Tamechika, Naohiko Seki, Tsutomu Yoshikawa, Motoyuki Otsuka, Kenji Nagahari, Yasuhiko Masuho
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Patent number: 7129338Abstract: Human cDNA encoding a secretory or membrane protein useful as a candidate for developing medicine or as a target molecule for developing medicine. The expression level of the polynucleotide of the present invention increased in NT2 cells after retinoic acid-treatment. Accordingly, this cDNA is associated neurological disease.Type: GrantFiled: November 27, 2002Date of Patent: October 31, 2006Assignee: Research Association for BiotechnologyInventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Kawai, Tomoyasu Sugiyama, Koji Hayashi
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Publication number: 20060148030Abstract: The present invention relates to novel nuclear receptor ERR?3. Although ERR?3 itself lacks a DNA binding domain, it comprises the function of enhancing the transcriptional activation function of arbitrary nuclear receptors, such as ERR, ER, or TR. Moreover, the present inventors found that, like ERR?3, the known proteins ERR?1 and ERR?2 also comprise the function of enhancing the transcriptional activation function of other nuclear receptors. Thus, the present invention provides methods for evaluating the regulatory function of these ERR? subtypes in enhancing the transcriptional activation function of other nuclear receptors, and screening methods based on these evaluation methods.Type: ApplicationFiled: March 25, 2003Publication date: July 6, 2006Applicant: FUJISAWA PHARMACEUTICAL CO., LTDInventors: Hitoshi Kojo, Kaoru Tajima, Masao Fukagawa, Shintaro Nishimura, Takao Isogai
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Publication number: 20060105376Abstract: Novel full-length cDNAs are provided. 2443 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: ApplicationFiled: December 5, 2005Publication date: May 18, 2006Inventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Ai Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Jun-ichi Yamamoto, Yuuko Isono, Yuri Hio, Kaoru Otsuka, Keiichi Nagai, Ryotaro Irie, Ichiro Tamechika, Naohiko Seki, Tsutomu Yoshikawa, Motoyuki Otsuka, Kenji Nagahari, Yasuhiko Masuho
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Patent number: 7029860Abstract: The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-? protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-? protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-? protein.Type: GrantFiled: December 17, 2004Date of Patent: April 18, 2006Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Hio, Mayako Yamazaki, Susumu Satoh, Hiroyuki Arakawa, Masahiko Morita
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Publication number: 20060029945Abstract: Novel full-length cDNAs are provided. 1970 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: ApplicationFiled: March 7, 2005Publication date: February 9, 2006Inventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Ai Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Jun-ichi Yamamoto, Yuuko Isono, Yuri Hio, Kaoru Otsuka, Keiichi Nagai, Ryotaro Irie, Ichiro Tamechika, Naohiko Seki, Tsutomu Yoshikawa, Motoyuki Otsuka, Kenji Nagahari, Yasuhiko Masuho
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Patent number: 6979557Abstract: Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: GrantFiled: March 12, 2002Date of Patent: December 27, 2005Assignee: Research Association for BiotechnologyInventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Ai Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Jun-ichi Yamamoto, Yuuko Isono, Yuri Hio, Kaoru Otsuka, Keiichi Nagai, Ryotaro Irie, Ichiro Tamechika, Naohiko Seki, Tsutomu Yoshikawa, Motoyuki Otsuka, Kenji Nagahari, Yasuhiko Masuho
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Publication number: 20050250144Abstract: Selection of clones having the kinase and/or phosphatase-like structure from clones which had been isolated and the structures thereof had been determined in the Helix Research Institute (helix clones; Japanese Patent Application No. 2000-183767) was conducted. Two novel genes were provided by carrying out homology search for all the helix clones by using the amino acid sequences of known kinases and phosphatases as queries. The genes are expected to be involved in intracellular signal transduction. The physiological functions of the inventive genes can be tested by using reporter gene assay systems capable of detecting signal transduction. The proteins of the present invention are useful as target molecules in drug discovery and in the development of new pharmaceuticals.Type: ApplicationFiled: April 19, 2005Publication date: November 10, 2005Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Chiaki Senoo, Jin-Ichi Nezu
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Patent number: 6960435Abstract: The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-? protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-? protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-? protein.Type: GrantFiled: July 6, 2000Date of Patent: November 1, 2005Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Hio, Mayako Yamazaki, Susumu Satoh, Hiroyuki Arakawa, Masahiko Morita
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Publication number: 20050214813Abstract: The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-? protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-? protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-? protein.Type: ApplicationFiled: December 17, 2004Publication date: September 29, 2005Applicant: Fujisawa Pharmaceutical Co. Ltd.Inventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Hio, Mayako Yamazaki, Susumu Satoh, Hiroyuki Arakawa, Masahiko Morita
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Publication number: 20050203283Abstract: The present invention relates to the novel isoforms, RXR?2 and RXR?3, of nuclear receptor RXR?. Unlike known isoform RXR?1, the transcriptional activation functions of RXR?2 and RXR?3 are augmented by SRC-1. The present invention provides methods for evaluating the function of regulating augmentation by co-activators of these RXR? isoforms, and screening methods based on these evaluation methods. By controlling the interaction between isoforms and co-activators, transcription-controlling activity can be regulated in an isoform-specific manner.Type: ApplicationFiled: March 25, 2003Publication date: September 15, 2005Inventors: Hitoshi Kojo, Kaoru Tajima, Masao Fukagawa, Shintaro Nishimura, Takao Isogai
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Patent number: 6943241Abstract: Novel full-length cDNAs are provided. 1970 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of the polypeptide.Type: GrantFiled: March 25, 2002Date of Patent: September 13, 2005Assignee: Research Association for BiotechnologyInventors: Takao Isogai, Tomoyasu Sugiyama, Tetsuji Otsuki, Ai Wakamatsu, Hiroyuki Sato, Shizuko Ishii, Jun-ichi Yamamoto, Yuuko Isono, Yuri Hio, Kaoru Otsuka, Keiichi Nagai, Ryotaro Irie, Ichiro Tamechika, Naohiko Seki, Tsutomu Yoshikawa, Motoyuki Otsuka, Kenji Nagahari, Yasuhiko Masuho
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Publication number: 20050164934Abstract: A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.Type: ApplicationFiled: February 4, 2005Publication date: July 28, 2005Applicants: Kenji Sobue, Chugai Seiyaku Kabushiki KaishaInventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Shoji Miyata, Kenji Sobue, Kenichiro Hayashi
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Patent number: 6908748Abstract: A cDNA fragment participating in the maintenance of smooth muscle differentiation was isolated using a culture system of chicken gizzard smooth muscle cells, the differential display method and the subtracted hybridization method. Using the obtained cDNA sequence as a query, cDNA sequences of Helix Research Institute (Japanese Patent Application No. 2000-118776) were retrieved, and thus, a novel gene “C-NT2RP3001495” was obtained. The protein encoded by this gene has two WW domains that participate in protein interactions in the N-terminal domain. Evidence suggests that this protein binds to other proteins, and thus regulates the intracellular signal transduction, gene expression, and so on, thereby participating in the maintenance of the differentiation of smooth muscle cells. This protein and compounds regulating the expression thereof are markedly useful in developing drugs for various diseases associated with abnormality in the maintenance of smooth muscle cell differentiation.Type: GrantFiled: January 28, 2002Date of Patent: June 21, 2005Assignees: Chugai Seiyaku Kabushiki KaishaInventors: Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Koji Hayashi, Kaoru Otsuka, Jun-Ichi Yamamoto, Shizuko Ishii, Tomoyasu Sugiyama, Ai Wakamatsu, Keiichi Nagai, Tetsuji Otsuki, Shin-Ichi Funahashi, Shoji Miyata, Kenji Sobue, Kenichiro Hayashi
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Patent number: 6878525Abstract: A cDNA encoding a novel LTC4 receptor has been isolated. Provision of the novel protein, an LTC4 receptor, enabled binding experiments using the LTC4. By screening for compounds that modulate LTC4 receptor activity based on these binding experiments, development of drugs targeting the LTC4 receptor becomes possible.Type: GrantFiled: September 13, 2000Date of Patent: April 12, 2005Assignees: Yamanouchi Pharmaceutical Co, Ltd., Helix Research InstituteInventors: Jun Takasaki, Masazumi Kamohara, Mitsuyuki Matsumoto, Tetsu Saito, Tohru Sugimoto, Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Kawai
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Publication number: 20050037968Abstract: A cDNA encoding a novel LTC4 receptor has been isolated. Provision of the novel protein, an LTC4 receptor, enabled binding experiments using the LTC4. By screening for compounds that modulate LTC4 receptor activity based on these binding experiments, development of drugs targeting the LTC4 receptor becomes possible.Type: ApplicationFiled: September 2, 2004Publication date: February 17, 2005Inventors: Jun Takasaki, Masazumi Kamohara, Mitsuyuki Matsumoto, Tetsu Saito, Tohru Sugimoto, Toshio Ota, Takao Isogai, Tetsuo Nishikawa, Yuri Kawai
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Publication number: 20040157256Abstract: A cDNA library in which sense strand cDNAs are immobilized at the 5′-side is provided. A known nucleotide sequence is artificially added to the 3′-side of an antisense strand cDNA (the first strand) and the 5′-side of the second strand is immobilized by using a primer complementary to the above nucleotide sequence. Thus, a cDNA library with excellent qualities, which contain the full-length cDNA at a high possibility, can be obtained.Type: ApplicationFiled: March 1, 2004Publication date: August 12, 2004Applicant: Taisho Pharmaceutical Co., Ltd.Inventors: Toshio Ota, Masato Mitsuhashi, Takao Isogai, Ai Wakamatsu
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Publication number: 20040147720Abstract: The clone PLACE6002312 having a structure characteristic of G protein-coupled receptor was isolated from a human placental full-length cDNA library prepared by the oligo-capping method. Database search revealed that PLACE6002312 had the highest homology to HISTAMINE H2 RECEPTOR. Analysis for the expression of PLACE6002312 gene in human tissues revealed that the gene was expressed in various tissues, such as heart, liver, and ovary. In addition, histamine was found to be one of ligands for PLACE 6002312 by ligand-binding assay. Furthermore, a full-length cDNA for the mouse homolog of PLACE6002312 was isolated, and the deduced amino acid sequence was revealed to comprise a structure characteristic of G protein-coupled receptor. PLACE6002312 can be used to screen for agonists and antagonists useful as pharmaceuticals and to diagnose various diseases caused by the abnormal activity or expression of the polypeptide.Type: ApplicationFiled: February 9, 2004Publication date: July 29, 2004Inventors: Tomoyasu Sugiyama, Noriyuki Morikawa, Ai Wakamatsu, Tamaki Oda, Ryotaro Irie, Takao Isogai, Yasuhiko Masuho
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Publication number: 20040115726Abstract: Disclosed in this invention are methods, systems, databases, user-interfaces, software, media, and services useful for evaluating interactions between chemical compounds and proteins and for utilizing the information resulting from such evaluation for the purpose of discovering chemical compounds for medical and other fields. An approach termed “reverse proteomics” is disclosed. This invention generates an enormously large pool of new target proteins for drug discovery, novel methods for designing of new drugs, and a previously unthinkable pool of virtually synthesized small molecules for therapeutic uses. This invention is also applicable, for example, to discovery of substitutes for environmentally hazardous chemicals, more effective agrochemicals, and healthier food additives.Type: ApplicationFiled: June 11, 2003Publication date: June 17, 2004Inventors: Renpei Nagashima, Takao Isogai, Noriaki Hirayama