Abstract: This disclosure relates to compounds of formula (I) as defined in the Specification. This disclosure also relates to methods of synthesizing the compound of formula (I) and using the compounds of formula (I) for treating a disease (e.g., cancer).

Abstract: The present invention provides a novel compound inhibiting EGFR or a salt of the compound. According to one embodiment of the present invention, provided is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: This disclosure relates to compounds of formula (I) as defined in the Specification. This disclosure also relates to methods of synthesizing the compound of formula (I) and using the compounds of formula (I) for treating a disease (e.g., cancer).

Abstract: The present invention provides a novel compound inhibiting EGFR or a salt of the compound. According to one embodiment of the present invention, provided is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof.

Abstract: A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof.

Abstract: A pyrrolopyrimidine compound or a salt thereof and compositions, NAE inhibitors and anti-tumor agents containing the pyrrolopyrimidine compound or a salt thereof.

Abstract: An object to be solved by the present invention is to provide a novel pyrrolopyrimidine compound or a salt thereof having an NAE inhibitory action and a cell growth inhibitory effect. The present invention provides a compound or a salt thereof represented by Formula (A), as well as an NAE inhibitor, a pharmaceutical composition, and an antitumor agent comprising the compound or a salt thereof as an active ingredient.

Abstract: A catalyst-carrying filter includes a gas-inflow-side layer and a gas-outflow-side layer, the gas-inflow-side layer including a PM collection layer that has a small average pore size and a PM removal catalyst layer that supports or is coated with an oxidizing catalyst, and the gas-outflow-side layer including a gas purification catalyst layer that supports or is coated with a gas purification catalyst. An amount of oxidizing catalyst supported on the PM collection and PM removal catalyst layer is larger than that of the gas purification catalyst layer by a factor of 1.05 to 10 and an amount of noble metal contained in the PM collection and PM removal catalyst layer is smaller than an amount of noble metal contained in the gas purification catalyst layer.

Abstract: In a honeycomb filter 20, partition portions and trapping layers are formed such that a pore volume difference that is obtained from pore distributions measured by mercury porosimetry and is a difference in volume of pores having a diameter of 10 ?m or less between the downstream portion and the upstream portion of the honeycomb filter, is in the range of 0.01 cm3/g or more and 0.08 cm3/g or less. In the honeycomb filter, in the downstream portion, a first pore volume peak is present in a first pore diameter range of 2 ?m or more and 9 ?m or less and a second pore volume peak that is higher than the first pore volume peak is present in a second pore diameter range of 10 ?m or more and 25 ?m or less.

Abstract: A frame image acquiring unit acquires a captured image of an input device that is provided with an illuminator. A device information deriving unit derives position information of the input device from the captured image. An input receiving unit acquires attitude information of the input device. An operation object control unit controls the motion of an operation object in accordance with the position information and the attitude information of the input device. A non-operation object control unit controls the motion of a non-operation object. A collision control unit determines the motion of at least one of the operation object and the non-operation object in accordance with a collision mode for the collision between the operation object and the non-operation object.

Abstract: A honeycomb filter includes a cell having one open end and another closed end that serves as a fluid flow path and a cell having one closed end and another open end, wherein the cells are alternately disposed. The honeycomb filter includes an undeposited region in an upstream region of a partition portion, which has no trapping layer and has a length of 5% or more and 30% or less of the length of the inlet cell. The upstream region of the partition portion includes an undeposited region having an area of 10% or more of that of the cell in a cross-section perpendicular to the exhaust gas flow direction. The undeposited region with no trapping layer in the upstream region decreases the permeation resistance of the partition portion in the upstream region and facilitates fluid passage through the partition portion in the upstream region.

Abstract: There is provided a honeycomb filter wherein particles having an average particle diameter smaller than the average pore diameter of partition walls are deposited at least in open pores formed in the surface layer of the partition wall and in the pores of the partition wall in a surface layer portion of the partition walls on the exhaust gas inflow side, thereby forming a composite region. The average pore diameter of the partition walls is 5 to 40 ?m, and the porosity of the partition wall is 35 to 75%. The particles to be deposited have an average particle diameter of 1 to 15 ?m, and the height of the composite region is not more than 80 ?m in the direction from the outermost contour line of the partition walls to the surface of the partition walls.

Abstract: There is provided a honeycomb filter wherein particles having an average particle diameter smaller that of the particles constituting partition walls are deposited at least in open pores formed by the particles constituting the partition walls and/or gaps between the particles in a surface layer portion of the partition walls on the exhaust gas inflow side, thereby forming a composite region. The average pore diameter of the partition walls is 5 to 40 ?m, and the porosity of the partition wall is 35 to 75%. The particles to be deposited have an average particle diameter of 1 to 15 ?m, and the height of the composite region is not more than 80 ?m in the direction from the outermost contour line of the partition walls to the surface of the partition walls.

Abstract: An energization control apparatus includes a control portion, a disconnection detecting portion, and a prohibiting portion. The control portion controls energization to a plurality of loads coupled in parallel. The disconnection detecting portion repeatedly or continuously determines whether a supply current to the plurality of loads is less than a threshold value when the control portion energizes the plurality of loads, and the disconnection detecting portion detects a disconnection of a part of the plurality of loads when the supply current is less than the threshold value. The prohibiting portion prohibits a disconnection detection by the disconnection detecting portion for a predetermined period since the control portion starts to energize the plurality of loads, and the prohibiting portion enables the disconnection detection by the disconnection detecting portion after the predetermined period elapses.

Abstract: A honeycomb filter includes a plurality of porous partition portions each forming a cell, which is open at one end and closed at the other end and serves as an exhaust gas flow path, and a trapping layer, for trapping and removing solid components contained in the exhaust gas, formed on each of the partition portions. At least part of each of the partition portions is loaded with a catalyst. The amount of catalyst a (g/L) in an upstream partition portion and the amount of catalyst b (g/L) in a downstream partition portion satisfy 1.05?a/b?3.00. A method for, limiting a/b to this range includes the entire honeycomb structure, including the partition portions, into contact with a catalyst component to form a catalyst, and subsequently bringing only an upstream region of the honeycomb structure into contact with a catalyst component to form a catalyst.

Abstract: A meter system includes: an indicator including a pointer, a step motor, a stopper mechanism and a driving controller; and a flasher function unit including a flasher switch, a flasher and a flasher controller. The driving controller has: a stopper position detection operation executing element for executing a pointer moving away operation when a stopper position detection operation executing condition is satisfied and for executing a voltage detection type zero point stopper position detection operation when the executing condition is satisfied, and the flasher switch does not turn on and off, and a zero point return enforcement type zero point stopper position detection operation when the executing condition is satisfied, and the flasher switch turns on and off; a zero point setting element; and an applying element for applying the driving signal having the zero point.

Abstract: A honeycomb filter 20 includes a plurality of porous partition portions 22 forming a plurality of cells 23 serving as channels of fluid and trapping layers 24 that are formed on the partition portions and configured to trap a solid component contained in the fluid. In the honeycomb filter 20, a predetermined trapping region present on the partition portions 22 satisfies that, in an inscribed-circle-diameter distribution obtained by dividing an image of the partition portions captured with an electron microscope into a material region and a plurality of pore regions and by drawing maximum inscribed circles individually inscribed in the pore regions, a median pore diameter D50 is 1 ?m or more and 6 ?m or less and a median pore diameter D80 is 1 ?m or more and 7 ?m or less, and an inscribed-circle porosity determined from the inscribed-circle-diameter distribution is 35% or more and 60% or less.

Abstract: The honeycomb filter is constructed as a diesel particulate filter having a filtration function for filtering out the particulate matter included in an exhaust emission of a diesel engine. The honeycomb filter has a honeycomb structure as a base and inlet opening cells with surface layers formed on respective inner surfaces thereof. The surface layer has zero film thickness in an inlet peripheral region. Separation vortexes are generated in the inlet peripheral regions. The zero film thickness of the surface layers in the inlet peripheral regions naturally causes non-flaking of the surface layers induced by the separation vortexes generated in the inlet peripheral regions and thereby leads to non-production of flakes. In the non-existent condition of flakes, the overall surface layers are not collapsed by collision of the flakes.

Abstract: A honeycomb filter including a catalyst-carrying article, and an outer peripheral coat layer disposed on an outer peripheral face of the catalyst carrying article, wherein an amount of the catalyst loaded in the outer peripheral coat layer at a position 50 ?m or more apart from a boundary face between the catalyst-carrying article and the outer peripheral coat layer is 5 mass % or less when a measurement piece having a cross section where a boundary portion between the catalyst-carrying article and the outer peripheral coat layer can be observed and being obtained by embedding a resin in the boundary portion in the cross section is measured by an energy dispersive fluorescent X-ray analysis using a scanning electron microscope.