Abstract: Each pixel has a reflection region to produce a display in reflection mode. The first substrate includes: a pixel electrode for each pixel; and a first vertical alignment film. The second substrate includes: an opposite electrode opposite the pixel electrodes; and a second vertical alignment film. Of the first and second vertical alignment films, only the second vertical alignment film exerts an alignment-regulating force that determines a pretilt angle. Each pixel electrode includes a plurality of subpixel electrodes. The opposite electrode has an opening in an area corresponding to one of four corners of at least one of the plurality of subpixel electrodes. Liquid crystal molecules in a thickness-wise middle portion of the liquid crystal layer on the subpixel electrode are oriented toward the opening.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: A magenta toner is provided. The magenta toner comprises toner particles each comprising a binder resin and a colorant. From 1.0% to 25.0% by number of the toner particles have a CH rate of 25.0% or more in absolute value. The CH rate is calculated from the following formula (1): CH rate (%)=[(In?Iave)/Iave]×100??Formula (1) where, in a Raman spectrum of each toner particle, In represents an integrated intensity within a wavenumber region of from 2,750 to 3,250 cm?1 when an intensity at a wavenumber ? within a wavenumber region of from 1,200 to 3,250 cm?1 is s normalized to 1, where a total intensity of all the toner particles is maximum at the wavenumber ?; and Iave represents an average of the In.

Abstract: Each pixel has a reflection region to produce a display in reflection mode. The first substrate includes: a pixel electrode for each pixel; and a first vertical alignment film. The second substrate includes: an opposite electrode opposite the pixel electrodes; and a second vertical alignment film. Of the first and second vertical alignment films, only the second vertical alignment film exerts an alignment-regulating force that determines a pretilt angle. Each pixel electrode includes a plurality of subpixel electrodes. The opposite electrode has an opening in an area corresponding to one of four corners of at least one of the plurality of subpixel electrodes. Liquid crystal molecules in a thickness-wise middle portion of the liquid crystal layer on the subpixel electrode are oriented toward the opening.

Abstract: The purpose of the present invention is to provide a molecule having a significant effect on the development of fibrosis and a substance capable of inhibiting fibrosis. This biomarker for fibrosis comprises RNA binding motif protein 7 (RBM7) and is useful as a biomarker for diagnosis of fibrosis. This fibrosis detection method comprising the step of detecting RBM7 in a biological sample from a subject preferably using an anti-RBM7 antibody is useful for diagnosis of fibrosis. This antifibrotic agent containing a substance which inhibits the expression of RBM7, preferably at least one nucleic acid drug selected from the group consisting of siRNAs, shRNAs, dsRNAs, miRNAs, and antisense nucleic acids against RBM7, is useful for treatment of fibrosis.

Abstract: A reflective-type liquid crystal display device includes: a first substrate including a light-reflective first electrode; a second substrate including a light-transmissive second electrode; a liquid crystal layer that is provided between the first electrode and the second electrode and takes a generally vertical alignment during black display; a polarizing layer provided on a viewer side of the second substrate; and a first retardation layer, a second retardation layer and a third retardation layer that are arranged in this order from a side of the polarizing layer, wherein 40°?|?3?2×?2+2×?1|?50°, 130°?|?3?2×?2+2×?1|?140°, 220°?|?3?2×?2+2×?1|?230° or 310°?|?3?2×?2+2×?1|?320° is satisfied, where ?1 denotes an angle formed between an absorption axis or a transmission axis of the polarizing layer and a slow axis of the first retardation layer, ?2 an angle formed between the absorption axis or the transmission axis of the polarizing layer and the slow axis of second retardation layer, and ?3 an angle formed betwe

Abstract: A liquid crystal display device includes a first substrate, a second substrate, a liquid crystal layer, and a plurality of pixels. Each of the pixels has a reflection region for performing display in a reflective mode. The first substrate includes a pixel electrode provided in each of the pixels and a reflection layer positioned opposite to the liquid crystal layer with respect to the pixel electrode. The reflection layer has a first region positioned in each of the pixels and a second region positioned between any two pixels adjacent to each other. Voltages of an identical polarity are applied to the liquid crystal layer for any two pixels adjacent to each other in a row direction, for any two pixels adjacent to each other in a column direction, or for all the pixels.

Abstract: A liquid crystal display panel includes pixels including a reflective region for display in a reflection mode and a transmissive region for display in a transmission mode. The liquid crystal display panel includes a liquid crystal layer including a nematic liquid crystal material having negative dielectric anisotropy and a chiral agent, a pixel electrode including a reflective conductive layer and a transparent conductive layer, a counter electrode, a light diffusing structure provided in common to the reflective region and the transmissive region, and a first vertical alignment film provided between the pixel electrode and the liquid crystal layer, and a second vertical alignment film provided between the counter electrode and the liquid crystal layer.

Abstract: A liquid crystal cell 10A according to the present invention includes: a pair of substrates 11 and 12 facing each other and having alignment films 11a and 12a formed on surfaces of the substrates, respectively, the surfaces facing each other; and a liquid crystal layer LC interposed between the substrates 11 and 12. The alignment films 11a and 12a contain a polymer for alignment films which has a hydrazide functional group represented by Chemical Formula (1).

Abstract: A display device includes a reflective electrode, a driving circuit section, a wiring, and a wiring expansion section. The reflective electrode is divided into split electrodes arranged with spaces, which transmit light, respectively provided thereamong and reflects light. The driving circuit section drives the reflective electrode. The wiring is connected to at least the split electrodes and the driving circuit section and composed of a conductive material having a light transmission property. The wiring expansion section is formed to expand in the wiring to overlap the space.

Abstract: A liquid crystal display device includes an element substrate, a counter substrate, a liquid crystal layer sandwiched between the element substrate and the counter substrate, reflective electrodes placed on a surface of the element substrate that is located on the liquid crystal layer side, and a pair of alignment films each of which is placed on a corresponding one of a surface of the element substrate that is located on the liquid crystal layer side and a surface of the counter substrate that is located on the liquid crystal layer side. A liquid crystal composition contained in the liquid crystal layer contains a compound containing an alkoxy group. The alignment films contain a polymer including polyimide. The polyimide is derived from a polyamic acid and contains a side chain represented by Formula (1).

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: A reflective liquid crystal display device has a first substrate having a first electrode that reflects light; a second substrate having a second electrode that transmits light; a liquid crystal layer provided between the first electrode and the second electrode, including a nematic liquid crystal material having negative dielectric anisotropy ?? and a chiral agent, having nearly vertical alignment when no voltage is applied, and having twist alignment or hybrid alignment when white voltage is applied; and a polarizing layer provided on the observer side of the second substrate and at least one retarder layer disposed between the polarizing layer and the second substrate, wherein the reflective liquid crystal display device has a drive circuit that applies black voltage or white voltage across the liquid crystal layer at a frame rate of 1 fps or less, and when applying white voltage across the liquid crystal layer over a plurality of frames, the drive circuit applies the white display voltage whose polarity i

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: The present invention provides a liquid crystal display device which includes a reflective electrode, which achieves its low-voltage driving, and which suppresses flickering caused during its driving and image sticking caused by its long-term driving. The liquid crystal display device of the present invention includes: a first substrate provided with a reflective electrode configured to reflect ambient light; a second substrate facing the first substrate; a liquid crystal layer sandwiched between the first substrate and the second substrate and containing a liquid crystal material that contains a liquid crystal compound containing an alkoxy group and has negative anisotropy of dielectric constant; an alignment film provided on at least one of the first substrate and the second substrate on a side facing the liquid crystal layer; and an aromatic polymer that is present between the liquid crystal layer and the alignment film and/or within the alignment film and has a specific structure.

Abstract: A reflective liquid crystal display device has a first substrate having a first electrode that reflects light; a second substrate having a second electrode that transmits light; a liquid crystal layer provided between the first electrode and the second electrode, including a nematic liquid crystal material having negative dielectric anisotropy ?? and a chiral agent, having nearly vertical alignment when no voltage is applied, and having twist alignment or hybrid alignment when white voltage is applied; and a polarizing layer provided on the observer side of the second substrate and at least one retarder layer disposed between the polarizing layer and the second substrate, wherein the reflective liquid crystal display device has a drive circuit that applies black voltage or white voltage across the liquid crystal layer at a frame rate of 1 fps or less, and when applying white voltage across the liquid crystal layer over a plurality of frames, the drive circuit applies the white display voltage whose polarity i

Abstract: The present invention provides a liquid crystal display device in which flicker and image sticking caused by long-term use are suppressed.

Abstract: A liquid crystal cell 10A according to the present invention includes: a pair of substrates 11 and 12 facing each other and having alignment films 11a and 12a formed on surfaces of the substrates, respectively, the surfaces facing each other; and a liquid crystal layer LC interposed between the substrates 11 and 12. The alignment films 11a and 12a contain a polymer for alignment films which has a hydrazide functional group represented by Chemical Formula (1).

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: A manufacturing method of a mold, the mold having at its surface a plurality of recessed portions whose two-dimensional size is not less than 10 nm and less than 500 nm when viewed in a direction normal to the surface, the method including: (a) providing a mold base, (b) partially anodizing an aluminum alloy layer, thereby forming a porous alumina layer which has a plurality of minute recessed portions; and (c) after step (b), bringing the porous alumina layer into contact with a first etching solution, thereby enlarging the plurality of minute recessed portions of the porous alumina layer. Step (a) of providing the mold base includes (a1) providing a metal base, (a2) forming an aluminum alloy layer on the metal base, and (a3) forming a surface protection layer on the aluminum alloy layer. Step (a2) and step (a3) are performed in a same chamber.