Abstract: The present invention provides (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine, (R)-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)piperidine-2-ylmethyl]dibenzo[b,e][1,4]oxazepine, compounds analogous to them and pharmaceutical compositions containing such a compound. These compounds are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, particularly irritable bowel syndrome.

Abstract: In a settlement system 1, merchandise information of merchandise which a buyer B desires to purchase is stored in a mobile information terminal 10 where the merchandise information is then displayed in the form of a barcode. A POS terminal 20 of a convenience store P scans the barcode displayed in the mobile information terminal 10, thereby performing a settling procedure. The POS terminal 20 then stores settlement completion information in the mobile information terminal 10.

Abstract: The present invention provides an AP-1 activation inhibitor, NF-kappa B activation inhibitor, inflammatory cytokine production inhibitor, matrix metalloprotease production inhibitor, inflammatory cell adhesion molecule expression inhibitor, anti-inflammatory agent, antirheumatic agent, immunosuppressant, cancer metastasis inhibitor, remedy for arteriosclerosis and antiviral agent which contain the benzene derivative of the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: A process for preparing 2,6-diaminopurine-2′-deoxyriboside and 2′-deoxyguanosine. These compounds may be used as materials for pharmaceuticals, such as antiviral agents and the like, and particularly as starting materials for antisense oligonucleotides.

Abstract: A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. Another aspect of the invention provides (3-oxa-2-oxobicyclo?3,1,0!hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this compound by replacing the hydroxyl group of the compound with a leaving group followed by reaction with a purine derivative.

Abstract: A method for resolving optically impure 3-oxa-2-oxobicyclo?3.1.0!hexane-1-carboxylic acid esters. A method is provided for producing a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid.N-benzyl-.alpha.-phenylethylamine diastereomer salt. An enantiomer of N-benzyl-.alpha.-phenylethylamine is reacted with a 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid to produce a precipitate that is enriched in one diastereomer of the salt. After isolating the optically active salt, the N-benzyl-.alpha.-phenylethylamine may be separated to produce the corresponding 1-alkoxycarbonyl-2-hydroxymethylcyclopropane-1-carboxylic acid. Under acidic conditions, the carboxylic acid and hydroxyl groups undergo ring closure to afford the optically active 3-oxa-2-oxobicyclo?3.1.0!hexane-1-carboxylic acid ester.

Abstract: An intermediate for the production of (3-oxo-2-oxobicyclo?3,1,0!hexan-1-yl) methanol represented by formula (II): ##STR1## selected from the group of compounds (9)-(11) as shown below, wherein R.sup.1 represents a lower alkyl group, R.sup.3 and R.sup.

Abstract: A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. Another aspect of the invention provides (3-oxa-2-oxobicyclo?3,1,0!hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this compound by replacing the hydroxyl group of the compound with a leaving group followed by reaction with a purine derivative.

Abstract: A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.

Abstract: A balloon catheter has an inner tube communicating with a blood introduction port provided at a tip of the balloon portion. The inner tube is affixed to the inner wall of the catheter tube by adhesion, melt-bonding, or integral formation. The balloon catheter has a small channel resistance in the channel where the pressurized fluid which expands and contracts the balloon portion flows, even when the catheter tube has been bent, and enables expansion and contraction of the balloon portion with a good response. Another balloon catheter has the balloon portions at a range of the end sides of the balloon portions smaller in sectional area compared with the balloon portions at the tip sides. The catheter is able to effectively prevent side effects which occur only rarely but which are serious when they do occur. The catheter impairs as little as possible the effect of assisting the heart action inherent to the IABP method without special measurement of the diameter of the patient's blood vessels.

Abstract: Stilbene compounds of the following formula (I) or their pharmaceutically acceptable salts are effective as carcinostatics and of low toxicity: ##STR1## wherein X represents a hydrogen atom or a nitrile group, and Y represents an amino acid acyl group.

Abstract: A cyclopropane derivative represented by formula (I): ##STR1## wherein B represents a group of a purine derivative. In addition another aspect of the invention provides (3-oxa-2-oxobicyclo[3,1,0]hexan-1-yl)methanol and a method of preparing a cyclopropane derivative of formula (I) from this compound by replacing the hydroxyl group of the compound with a leaving group followed by reaction with a purine derivative.

Abstract: A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.

Abstract: A balloon catheter has an inner tube communicating with a blood introduction port provided at a tip of the balloon portion. The inner tube is affixed to the inner wall of the catheter tube by adhesion, melt-bonding, or integral formation. The balloon catheter has a small channel resistance in the channel where the pressurized fluid which expands and contracts the balloon portion flows, even when the catheter tube has been bent, and enables expansion and contraction of the balloon portion with a good response. Another balloon catheter has the balloon portions at a range of the end sides of the balloon portions smaller in sectional area compared with the balloon portions at the tip sides. The catheter is able to effectively prevent side effects which occur only rarely but which are serious when they do occur. The catheter impairs as little as possible the effect of assisting the heart action inherent to the IABP method without special measurement of the diameter of the patient's blood vessels.

Abstract: The present invention provides a pharmaceutical agent having a high pharmaceutical potency against varicella-zoster viruses and herpes simplex viruses, compositions containing the same, and methods for treating varicella-zoster viruses using the same.

Abstract: Anisomycin derivatives represented by the following formula: ##STR1## and salts thereof, wherein R is hydrogen or an acyl group of 1-18 carbon atoms, and X is either a carbamoyl group represented by the formula --CONR.sup.1 R.sup.2 or an alkyl group represented by the formula --CH.sub.2 R.sup.3 in which R.sup.1 and R.sup.2 are each hydrogen, a linear or cyclic alkyl group of 1-6 carbon atoms which may have a substituent or a phenyl group which may have a substituent, and R.sup.3 is hydrogen, an alkyl group of 1-6 carbon atoms or an alkoxy group of 1-6 carbon atoms which may have a substituent, have improved stability in blood or plasma and are useful as anticancer agents, antifungal agents and antiprotozoan agents.

Abstract: A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antiviral effect.

Abstract: A temporary pacing catheter having an integrally attached temporary pacemaker function is disclosed. The pacemaker integrally built in this catheter for temporary pacing has a very small size and can be fixed to the body of a patient, and therefore, the patient can be transferred conveniently. Furthermore, if this catheter is packaged in the sterilized condition, problems or another's help required for the connection of the catheter to the pacemaker and the like operations in the conventional technique can be avoided, and therefore, the packaged catheter is suitably used for an emergency treatment. Moreover, if a balloon is attached and arranged so that when the balloon is inflated, the balloon envelopes an electrode at the distal end, the catheter can be caused to flow in the heart and blood vessel safely and promptly.

Abstract: A cyclopropane derivative of formula (I) ##STR1## wherein B.sup.1 is a purine or pyrimidine residue, R.sup.1 and R.sup.2 are, independently, hydrogen or a protecting group for hydroxyl and each of k, m and n represents, independently, an integer of 1 or 2 is useful for its antiviral effect.

Abstract: 1,4-dihydropyridine derivatives of Formula 1 or pharmaceutically acceptable salts thereof: ##STR1## wherein the substituents are disclosed herein and which are useful against tumor cells which have acquired resistance to one or more drugs used as chemotherapeutic agents.