Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.

Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.

Abstract: An optical amplifier includes a polarization splitter, a polarization rotator, first and second optical couplers, and first and second semiconductor optical amplifying devices. The TE polarized wave of light split by the polarization splitter is input to a first input port of the first optical coupler. The TM polarized wave of the split light is converted into a TE polarized wave by the polarization rotator to be input to a second input port of the first optical coupler. First light and second light output from a first output port and a second output port of the first optical coupler are amplified by the first semiconductor optical amplifying device and the second semiconductor optical amplifying device to be input to a first input port and a second input port of the second optical coupler, respectively. Third light is output from an output port of the second optical coupler.

Abstract: An image reading device includes a magnetizer that magnetizes a metal object attached to a document, a magnetism detector that is disposed on the downstream side of the magnetizer in a document transport direction from a document stacking table toward the document transport path and detects residual magnetism of the metal object, and a metal object accompaniment determination unit that determines whether or not the metal object is attached to the document based on a detection result by the magnetism detector.

Abstract: The present invention is provided with: a shipment amount predicting unit 16 for calculating, every field, predicted shipment amounts at respective shipment times in future based on the shipment plan data and the shipping actual result data stored in the database 11; an insufficiency situation predicting unit 17 for predicting an insufficiency situation such as which field, which shipment time and what amount of insufficiency of the agricultural product based on the calculated predicted shipment amounts at respective shipment times in future and the planned shipment amounts at respective shipment times in future; and an insufficiency situation notifying unit 18 for transmitting, to the demander terminal 2, predicted data on the insufficiency situation, thereby performing notification.

Abstract: An object of the present invention is to provide a tumor therapeutic agent and a kit which have superior antitumor effects as compared with gemcitabine, a taxane antitumor agent, and a combination therapy thereof which have been put on the market. According to the present invention, there is provided a tumor therapeutic agent obtained by combining a taxane antitumor agent with a liposome composition in which gemcitabine or a salt thereof is contained in a liposome.

Abstract: An optical element includes a first optical waveguide that extends from a first end portion toward a second end portion, and has a first active layer, a second optical waveguide that has a second active layer, and is disposed side by side with the first optical waveguide and extends from the first end portion toward the second end portion, a reflective film disposed on an end face of the first optical waveguide at a side of the first end portion, and an anti-reflection film disposed on an end face of the second optical waveguide at the side of the first end portion, wherein the anti-reflection film extends from a side of the second optical waveguide to the first optical waveguide at the first end portion, and the reflective film includes the anti-reflection film as one of constituent elements.

Abstract: At least one embodiment of the invention provides a multi-modal rechargeable battery pack that can switch between charging algorithms dynamically. This dynamic switching can be accomplished in a wide variety of ways, for example via external command or automatically. At least one embodiment of the invention provides a system that can switch a multi-modal rechargeable battery pack between one or more of a runtime mode, a lifespan mode, and a quick charge mode.

Abstract: An elevator car includes a car-platform device including a car-platform panel, anti-vibration devices, and a car-platform support frame. The car-platform panel includes a panel main body, a frame structure including a panel frame surrounding an outer peripheral portion of the panel main body, and a panel upper plate and a panel lower plate for individually covering upper surfaces and lower surfaces of the panel main body and the panel frame. The anti-vibration devices receive the frame structure by upper surfaces thereof. The car-platform support frame supports the car-platform panel through an intermediation of the anti-vibration devices. The upper surfaces of the anti-vibration devices are arranged at a height position between an upper surface and a lower surface of the car-platform panel in a vertical direction.

Abstract: Provided are a liposome composition in which an osmotic pressure of an inner water phase is 2-fold to 8-fold relative to the osmotic pressure of an outer water phase, and which encapsulates a water-soluble drug in a dissolved state, and also exhibits excellent preservation stability; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase; and a method for producing the same.

Abstract: In one embodiment, a security includes a planar EAS component having opposing first and second surfaces; and an adhesive layer adhered to the second surface of the planar EAS component and configured to adhere the planar EAS component to an object; wherein the first surface of the planar EAS component comprises a perforation line defining a closed interior portion of the planar EAS component and an exterior portion of the planar EAS component; and wherein the adhesive layer has a strength such that, when the adhesive layer is adhered to the object and the exterior portion is peeled away from the object, the planar EAS component tears along the perforation line and the interior portion remains adhered to the object.

Abstract: An optical waveguide includes a waveguide core including a first region, a second region having a step at which a thickness varies, and a third region having a thickness smaller than that of the first region. The second region has thick film regions continuing with the first region and positioned at both sides in a widthwise direction. The thick film regions have a thickness that is equal to that of the first region and have a gradually reducing width from the first region side to the third region side. The second region further has a thin film region sandwiched by the thick film regions and continuing with the third region. The thin film region has a thickness equal to that of the third region.

Abstract: In one embodiment, the invention can be a method for applying a security tag, the method including a cutting a portion of a top layer of a product packaging, the cutting comprising making cuts that form a closed shape, the cutting causing a break in the top layer that exposes a second layer of the product packaging; and adhering, via an adhesive, a security tag over the cut portion, the adhesive penetrating into the break in the top layer to contact the exposed second layer; wherein, upon removal of the security tag from the product packaging, a section of the cut portion of the top layer is removed from the product packaging.

Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.

Abstract: Provided are a liposome composition in which an osmotic pressure of an inner water phase is 2-fold to 8-fold relative to the osmotic pressure of an outer water phase, and which encapsulates a water-soluble drug in a dissolved state, and also exhibits excellent preservation stability; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase; and a method for producing the same.

Abstract: Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a drug in a dissolved state, an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase, and a release rate of the drug from each of the liposomes is 10%/24 hr to 70%/24 hr in blood plasma at 37° C.; and a method for producing the same.

Abstract: A substrate processing apparatus can efficiently perform a trial operation in conditions close to those of an actual operation. In the substrate processing apparatus 1 for taking substrates W out of a transfer chamber (FOUPs 1 to 4), processing the substrates W in each of processing modules 2 and returning the processed substrates W to the transfer chamber, a mode selection unit 31 selects an operation check mode for performing an operation check of wafer transfer devices 15 and 17 or the processing modules 2. Further, a job setting unit 32 sets control jobs for the operation check and a process job as a recipe executed on the substrate W. A controller 3 determines whether or not a first control job and a second control job to be executed subsequently after the first control job are allowed to be executed in parallel.

Abstract: The present invention is provided with: a shipment amount predicting unit 16 for calculating, every field, predicted shipment amounts at respective shipment times in future based on the shipment plan data and the shipping actual result data stored in the database 11; an insufficiency situation predicting unit 17 for predicting an insufficiency situation such as which field, which shipment time and what amount of insufficiency of the agricultural product based on the calculated predicted shipment amounts at respective shipment times in future and the planned shipment amounts at respective shipment times in future; and an insufficiency situation notifying unit 18 for transmitting, to the demander terminal 2, predicted data on the insufficiency situation, thereby performing notification.

Abstract: A management system includes a plurality of analyzers; and a computer system connected to the analyzers via a network, wherein each of the analyzers comprises: a data transmitter for transmitting data produced by the analyzer to the computer system via the network, and wherein the computer system includes a memory under control of a processor, the memory storing instructions enabling the processor to carry out operations, comprising: (a) receiving a plurality of data transmitted from the data transmitters of the plurality of analyzers; (b) generating an aggregate result used for determining a determination condition for making a determination as to whether or not a notification to a user of the analyzer is required based on the plurality of received data; and (c) outputting the aggregate result. A computer system and a method of providing information are also disclosed.

Abstract: An optical waveguide includes a waveguide core including a first region, a second region having a step at which a thickness varies, and a third region having a thickness smaller than that of the first region. The second region has thick film regions continuing with the first region and positioned at both sides in a widthwise direction. The thick film regions have a thickness that is equal to that of the first region and have a gradually reducing width from the first region side to the third region side. The second region further has a thin film region sandwiched by the thick film regions and continuing with the third region. The thin film region has a thickness equal to that of the third region.