Abstract: The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

Abstract: A system comprising a plurality of capture devices and a calibration device. The capture devices may each comprise a warp table. The calibration device may be configured to store a plurality of configured warp tables in a warp table pool, perform a full calibration for one of the capture devices to generate the configured warp tables, initiate a quick calibration for the capture devices and apply one of the configured warp tables to the capture devices as the warp table. The calibration device may apply one of the configured warp tables to the capture devices by selecting one of the configured warp tables from the warp table pool in response to the quick calibration. If the quick calibration fails, the calibration device may generate a new configured warp table for the warp table pool in response to the full calibration and select the new configured warp table.

Abstract: A system comprising a plurality of capture devices and a calibration device. The capture devices may each comprise a warp table. The calibration device may be configured to store a plurality of configured warp tables in a warp table pool, perform a full calibration for one of the capture devices to generate the configured warp tables, initiate a quick calibration for the capture devices and apply one of the configured warp tables to the capture devices as the warp table. The calibration device may apply one of the configured warp tables to the capture devices by selecting one of the configured warp tables from the warp table pool in response to the quick calibration. If the quick calibration fails, the calibration device may generate a new configured warp table for the warp table pool in response to the full calibration and select the new configured warp table.

Abstract: A control method for a continuously variable valve lift mechanism includes: controlling a continuously variable valve lift mechanism to enter a limp mode when the continuously variable valve lift mechanism fails and disables an automatic valve lift changing function; driving and forcing the continuously variable valve lift mechanism to move to a maximum lift position; and triggering a self locking function to self lock the continuously variable valve lift mechanism at the maximum lift position when the continuously variable valve lift mechanism reaches the maximum lift position. A control system for a continuously variable valve lift mechanism, and a vehicle are also provided.

Abstract: An apparatus comprising an interface, a light projector and a processor. The interface may be configured to receive pixel data. The light projector may be configured to generate a structured light pattern. The processor may be configured to process the pixel data arranged as video frames comprising the structured light pattern, perform computer vision operations to detect a size of a face area of the video frames, determine a scale ratio in response to the size of the face area, extract the structured light pattern from the video frames, generate a downscaled structured light image and generate a depth map in response to the downscaled structured light image and a downscaled reference image. A downscale operation may be performed in response to the scale ratio to generate the downscaled structured light image. The scale ratio may enable the generation of the downscaled structured light image with sufficient depth pixels.

Abstract: A system comprising a plurality of capture devices and a calibration device. The capture devices may each comprise a warp table. The calibration device may be configured to store a plurality of configured warp tables in a warp table pool, perform a full calibration for one of the capture devices to generate the configured warp tables, initiate a quick calibration for the capture devices and apply one of the configured warp tables to the capture devices as the warp table. The calibration device may apply one of the configured warp tables to the capture devices by selecting one of the configured warp tables from the warp table pool in response to the quick calibration. If the quick calibration fails, the calibration device may generate a new configured warp table for the warp table pool in response to the full calibration and select the new configured warp table.

Abstract: A soluble metal sealing ring with a controllable dissolution rate and preparation process thereof include an aluminum alloy sealing ring matrix and a composite coating coated on an outer surface of the aluminum alloy sealing ring matrix whose standard electrode potential is greater than -0.3 volts (V). The preparation process includes: (1) preparing a high-plastic aluminum alloy; (2) preparing the aluminum alloy sealing ring matrix by machining; (3) annealing the aluminum alloy sealing ring matrix; (4) mixing raw materials of the composite coating evenly; (5) preparing the composite coating on an outer surface of the aluminum alloy sealing ring matrix; (6) preparing holes. The soluble metal sealing ring solves problem that good sealing performance and good dissolving performance are difficult to obtain simultaneously in the existing product, and has advantages of good sealing performance, controllable dissolving rate, no blockage and others.

Abstract: Provided are a combined pharmaceutical composition of an anti-PD-L1 antibody and a c-Met kinase inhibitor, specifically, a combined pharmaceutical composition of an anti-PD-L1 antibody and N-(4-((7-((1-(cyclopentylamino)cyclopropyl)methoxy)-6-methoxyquinolin-4-yl)oxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and the use of the combined pharmaceutical composition in the treatment of cancers, in particular, gastric cancer or liver cancer.

Abstract: An electrochemical apparatus includes a negative electrode, where the negative electrode includes a current collector, a first coating, and a second coating. The second coating is provided on at least one surface of the current collector. The first coating is provided between the current collector and the second coating, and the first coating includes inorganic particles. A peeling force F between the first coating and the second coating satisfies 15 N?F?30 N. The first coating is provided between the current collector and the second coating of the negative electrode, and the first coating contains the inorganic particles, effectively enhancing adhesion between the current collector and the second coating, reducing the binder amount in the second coating, and increasing the proportion of a negative electrode active material in the negative electrode, thereby increasing the energy density of lithium-ion batteries.

Abstract: A replacement block pool for a memory device is established. The replacement block pool comprises one or more valid blocks from a set of valid blocks in the memory device determined based on a constraint defining a minimum number of valid blocks for the memory device. A grown bad block is detected in the memory device. The grown bad block is replaced with a replacement block from the replacement block pool in response to detecting the grown bad block.

Abstract: The present disclosure belongs to the technical field of analog or digital-analog hybrid integrated circuits, and relates to a high-speed SAR_ADC digital logic circuit, in particular to a high-speed digital logic circuit for SAR_ADC and a sampling adjustment method. The digital logic circuit includes a comparator, a logic control unit parallel to the comparator, and a capacitor array DAC. The comparator and the logic control unit are simultaneously triggered by a clock signal. The comparator outputs a valid comparison result Dp/Dn, the logic control unit outputs a corresponding rising edge signal, the rising edge signal is slightly later than Dp/Dn output by the comparator through setting a delay match, Dp/Dn is captured by the corresponding rising edge signal, thereby settling a capacitor array. The present disclosure eliminates the disadvantage of the improper settling of the capacitor array of the traditional parallel digital logic.

Abstract: A method for fabricating memory device includes: providing a substrate having a bottom electrode layer therein, forming a buffer layer and a mask layer on the buffer layer over the substrate, in contact with the bottom electrode layer, performing an advanced oxidation process on a sidewall of the buffer layer to form a resistive layer, which surrounds the whole sidewall of the buffer layer and extends upward vertically from the substrate, and forming, over the substrate, a noble metal layer and a top electrode layer on the noble metal layer, fully covering the resistive layer and the mask layer.

Abstract: The present disclosure discloses a method for the preparation of sulfinpyrazone, which is produced in two steps with a total yield of 48%, wherein thiophenol as the starting material is electrocatalytically coupled with dichloroethane to obtain 2-chloroethyl phenyl sulfoxide, which then undergoes a substitution reaction with 1,2-diphenyl-3,5-pyrazolidinedione to produce sulfinpyrazone. Compared with the prior art, the present method is characterized by high yield, short steps, less three wastes, good chemical selectivity, no need to use strong bases and oxidants, safe and simple operation, and easy to realize industrial production.

Abstract: The present disclosure may provide a radiation system. The radiation system may include a treatment head, a detector, a plurality of imaging sources, and a gantry. The treatment head, the detector, and the plurality of imaging sources may be mounted on the gantry. The treatment head may be configured to deliver a treatment beam toward an object. The plurality of imaging sources may be configured to deliver a plurality of imaging beams toward the object. At least two of the plurality of imaging sources may share the detector. The detector may be configured to detect at least two of the plurality of imaging beams. The detected at least two imaging beams may be emitted by different imaging sources of the at least two imaging sources.

Abstract: A multi-bit resolution sub-pipeline structure for measuring a jump magnitude of a transmission curve, comprising: a sub-analog-to-digital converter having n-bit resolution configured to quantize input analog voltage signals and output digital voltage signals; a sub-digital-to-analog converter having n-bit resolution configured to convert the digital voltage signals output by the sub-analog-to-digital converter into corresponding analog voltage signals; a decoder having n-bit resolution configured to decode an n-bit binary input signal; and a switched-capacitor amplification unit configured to, when in a normal mode, perform sampling and residue amplification on the input analog voltage signals; and when in a test mode, measure the jump magnitude of the transmission curve corresponding to each decision level. Magnitude measurement of a transmission curve is performed within 2n clock periods, th and a measurement result is sent to a back-end digital domain of the A/D converter for correction.

Abstract: Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein.

Abstract: A method of switching between first and second states of a van der Waals heterostructure, vdWH, memory device, a vdWH memory device, and a method of fabricating a vdWH memory device. The vdWH memory device comprises a first two-dimensional, 2D, material; and a second 2D material, wherein, in a first storage state of the memory device, an interface between the first and second 2D material comprises interfacial states; and wherein, in a second storage state of the memory device, interfacial states are modulated compared to the first memory state.

Abstract: A computer-implemented method, system, and computer program product for identifying requirements in a document. A document including requirements is received. Attribute related information in the document is identified using an attribute model. Component information in the document is identified using a component model. The attribute related information and the component information identified in the document are merged. Requirements in the document are identified from the merged attribute related information and component information. The requirements identified in the document are used to develop a product.

Abstract: Aspects of the present disclosure relate to optimization of packet processing when packets are received out of order in sequence. For example, a user equipment (UE) may determine whether a difference between a sequence number of a first packet and a sequence number of a second packet received subsequent to receiving the first packet exceeds a sequence jump threshold. The UE may disregard the second packet from processing in response to at least determining that the difference is greater than the sequence jump threshold. The UE may receive and process a plurality of packets respectively associated with a plurality of sequence numbers that are greater than the sequence number of the first packet and less than the sequence number of the second packet.

Abstract: The present disclosure may provide a radiation system including a first rotation portion, a second rotation portion, a treatment head, one or more imaging sources, and at least one detector. At least a portion of the treatment head may be disposed in the first rotation portion. At least one of the one or more imaging sources may be disposed in the second rotation portion. The second rotation portion may be able to rotate independently from the first rotation portion.