Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Abstract: This invention relates to a method of inhibiting the expression of TNF? or IL-1? with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.

Abstract: The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.

Abstract: Disclosed are methods for inhibiting TNF? expression, IL-1? expression, iNOS expression, and NF-?B activity and methods for treating autoimmune disease, cancer, or atherosclerosis with a compound of the following formula:

Abstract: This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

Abstract: Machine-readable media, methods, apparatus and system for obtaining and processing image features are described. In some embodiments, groups of training features derived from regions of training images may be trained to obtain a plurality of classifiers, each classifier corresponding to each group of training features. The plurality of classifiers may be used to classify groups of validation features derived from regions of validation images to obtain a plurality of weights, wherein each weight corresponds to each region of the validation images and indicates how important the each region of the validation images is. Then, a weight may be discarded from the plurality of weights based upon a certain criterion.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: A switching power supply includes a rectifier circuit, a converter, a detecting unit, a control unit, a switching unit, and a protection unit. The rectifier circuit is used for rectifying an input voltage into a first direct current voltage. The converter is configured for generating a first current according to the first direct current voltage. The detecting unit is used for generating a detected voltage according to the first current. The control unit is configured for generating a control signal. The switching unit is used for enabling the converter, and conducting the first current to the detecting unit when receiving the control signal. The protection unit is configured for shunting the first current with the detecting unit when the first current becomes a large current surge. The control unit stops generating the control signal when determining that the detected voltage is equal to or higher than a predetermined value.

Abstract: The present invention addresses at least four different aspects relating to catalyst structure, methods of making those catalysts and methods of using those catalysts for making alkenyl alkanoates. Separately or together in combination, the various aspects of the invention are directed at improving the production of alkenyl alkanoates and VA in particular, including reduction of by-products and improved production efficiency. A first aspect of the present invention pertains to a unique palladium/gold catalyst or pre-catalyst (optionally calcined) that includes rhodium or another metal. A second aspect pertains to a palladium/gold catalyst or pre-catalyst that is based on a layered support material where one layer of the support material is substantially free of catalytic components. A third aspect pertains to a palladium/gold catalyst or pre-catalyst on a zirconia containing support material.

Abstract: A Coriolis mass flowmeter has a measuring tube that can be excited to oscillation, an oscillation driver and/or an oscillation sensor, wherein the oscillation driver and/or the oscillation sensor has a permanent magnet. The permanent magnet is arranged in a magnet holder so that a sure and simple fixation of the permanent magnet is achieved.

Abstract: A method, apparatus and system for, for each of a plurality of image frames, assigning a pattern number to each of a set of pixel neighborhoods within the frame and assigning a relationship number to each of a plurality of sets of pattern numbers based on a probability of transitioning between different pattern numbers in the set of pattern numbers when transitioning between different pixel neighborhoods. For a subset of the plurality of frames, the subset of frames may be determined to be similar, for example, based on the similarity of the relationship numbers of the subset of the plurality of frames. Other embodiments are described and claimed.

Abstract: A regulator includes a power-converting circuit and a protection circuit. The power-converting circuit is for converting a primary voltage to a secondary voltage. The protection circuit is coupled to the power-converting circuit. The protection circuit receives the primary voltage earlier than the power-converting circuit. When a voltage spike of the primary voltage occurs, the protection circuit shunts the high instantaneous voltage to ground. An electrical device and a car using the regulator is also provided.

Abstract: A method of testing a mass flow rate meter functioning on the Coriolis principle, in which an apparatus of the mass flow rate meter is subjected to a predetermined oscillation excitation and the associated oscillation response is recorded. Then the recorded oscillation response is compared with a previously recorded oscillation response. Testing of the Coriolis mass flow rate meter with regard, for example, to error tolerances in the manufacturing or with regard to a calibration condition is thereby enabled.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

Abstract: The present invention addresses at least four different aspects relating to catalyst structure, methods of making those catalysts and methods of using those catalysts for making alkenyl alkanoates. Separately or together in combination, the various aspects of the invention are directed at improving the production of alkenyl alkanoates and VA in particular, including reduction of by-products and improved production efficiency. A first aspect of the present invention pertains to a unique palladium/gold catalyst or pre-catalyst (optionally calcined) that includes rhodium or another metal. A second aspect pertains to a palladium/gold catalyst or pre-catalyst that is based on a layered support material where one layer of the support material is substantially free of catalytic components. A third aspect pertains to a palladium/gold catalyst or pre-catalyst on a zirconia containing support material.

Abstract: An audio apparatus includes a speaker having an output surface from which sound waves of the speaker radiate out; and a vibration absorbing member housing the speaker therein. The vibration absorbing member including a vibration absorbing portion attached to the output surface of the speaker, and a fastening portion connecting and surrounding the vibration absorbing portion and sleeves on the speaker configured for attaching the vibration absorbing member to the speaker. The vibration absorbing portion defining a through hole for allowing the sound waves from the speaker to radiate out.

Abstract: An exemplary punch die (30) includes a lower die (40) and an upper die (50). The lower die includes a die core (45), a blank holder (417), and a cylinder (413) disposed in the lower die. The blank holder is disposed on a periphery of the die core. The cylinder is connected to the blank holder and provides a constant force to the blank holder. The upper die includes a punch core corresponding to the die core. A punch machine using the present punch die is also provided.

Abstract: An image feature within image data may be identified and located from the maximum values in a Hough voting table. The Hough voting table may be generated by converting edge pixels identified with an image data into an array. The array may be read in row order with theta on the outside loop and rho on the inside loop. In some embodiments, the storage requirements for the Hough voting table may be reduced.

Abstract: An exemplary film-removing device for removing a protecting film from a workpiece includes a main body and a film-removing mechanism. The film-removing mechanism includes a suspending arm and a roller. The suspending arm has a first end rotatably connected to the main body. The roller is rotatably connected to a second end, opposite to the first end, of the suspending arm. The roller is driven to rotate by movement of the workpiece.