Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: A hydraulically controlled backing roller includes a mandrel, two cover plates which are installed at two ends of the mandrel through screws respectively, and two screwdown gears which are installed at two end portions of the mandrel respectively. The two screwdown gears are engaged with an output rack of a screwdown hydraulic cylinder, multiple saddle ring sets are sleeved on the mandrel at equal intervals, a saddle ring of each of the saddle ring sets is fixed with a frame through a fan-shaped plate, a backing bearing is provided between two adjacent saddle ring sets; an inner eccentric ring of the each of the saddle ring sets is driven to rotate by hydraulic driving, so that the mandrel has a deflection deformation, and the deflection deformation is transmitted to other adjacent rollers through the backing bearing.

Abstract: A rolling device capable of applying horizontal vibration for metal clad plates includes two symmetrically arranged support frames, an upper roller and a lower roller both of which are provided between the two support frames and parallel to each other, four bearing seats which are fixed with two ends of the upper roller and two ends of the lower roller respectively, and four horizontal vibration apparatuses which are provided outside the four bearing seats respectively for driving the upper roller and the lower roller to horizontally vibrate. Every horizontal vibration apparatus includes an exciting hydraulic cylinder and a damper. One end of the exciting hydraulic cylinder and one end of the damper are fixedly connected with two sides of one of the four bearing seats respectively. Every horizontal vibration apparatus is provided outside one of the four bearing seats.

Abstract: The present disclosure concerns a device for forming a multi-flavor composite structure filter rod in one step, including the following components: a tow transmission belt, a tow guiding horn-shaped mouth, a tow assembly paper collection groove, a cigarette lap adhesive applying device and multi-flavor adding devices. According to shapes and types of flavors, the multi-flavor adding devices are arranged in different sections to obtain one-step formation of the multi-flavor composite structure filter rods. The present disclosure also discloses a one-step method of forming the multi-flavor composite structure filter rod using the one-step forming device.

Abstract: Disclosed in the present invention is a prevention and control method of nitrogen protection and multi-region level-by-level detection for an energy storage power station. The prevention and control method of nitrogen protection and multi-region level-by-level detection for an energy storage power station includes two modes: a normal operating mode and an abnormal mode. In the two modes, fire extinguishing measures of different levels are adopted for a battery pack, a battery cluster, a battery compartment, and a device compartment with reference to early warning thresholds of different levels. Further disclosed is a prevention and control system of nitrogen protection and multi-region level-by-level detection for an energy storage power station.

Abstract: A tank is secured under the keel of a floating structure for offshore energy development. The tank is filled with ballast material that supplements or replaces the ballast already present on the floating structure, thereby gaining larger topsides payload capacity for the floating structure or increasing stability and motion performance of the floating structure.

Abstract: A method for reducing the negative effect of heat acclimatization for the hatching of a poultry hatching egg is provided. A special light source is used as an ambient light to hatch the poultry hatching egg. The special light source is light-emitting diode (LED) monochromatic blue light with a light intensity of 20 lux to 50 lux and a wavelength of about 450 nm, such that the light can reduce the negative effect of heat acclimatization at a hatching stage of the poultry hatching egg. The method can reduce the levels of oxidation products such as malondialdehyde (MDA) and corticosterone in a chicken embryo during heat acclimatization at the hatching stage of the poultry hatching egg and increase the expression levels of antioxidase and heat shock protein (HSP) genes, and the special light source reduces the metabolic heat production of the chicken embryo.

Abstract: A temperature demodulation method oriented toward a distributed fiber Raman temperature sensing system, the method comprising the following steps: step 1 of constructing a high-precision temperature detection device oriented towards a distributed fiber Raman sensing system; step 2 of performing signal processing with respect to Stokes light and anti-Stokes light at a calibration stage; step 3 of performing signal processing with respect to Stokes light and the anti-Stokes light at a measurement stage; and step 4 of obtaining a high-precision temperature demodulation technique oriented toward the distributed fiber Raman sensor. The method is used to effectively resolve the issue of low temperature measuring accuracy caused by Rayleigh crosstalk in existing distributed fiber Raman temperature measurement systems, and temperature measurement accuracy thereof is expected to fall within ±0.1° C. The method is applicable to distributed fiber Raman temperature measurement systems.

Abstract: An unmanned aerial vehicle (UAV) includes one or more processors individually or collectively configured to assess a location of the UAV, calculate a distance between the UAV and a flight-restricted region using the location of the UAV, assess whether the distance falls within a first distance threshold, and instruct the UAV to take a flight response measure selected from (1) a first flight response measure when the distance falls within the first distance threshold, and (2) a second flight response measure different from the first flight response measure when the distance falls outside the first distance threshold. The first flight response measure at least includes causing the UAV to descend or hover over a location. A rate at which the UAV descends is determined based on the location of the UAV.

Abstract: Neoantigens play a key role in the recognition of tumor cells by T cells. However, only a small proportion of neoantigens truly elicit T cell responses, and fewer clues exist as to which neoantigens are recognized by which T cell receptors (TCRs). To help determine the TCRs that interact with particular neoantigens, prediction models that predict TCR-binding specificities of neoantigens presented by different classes of major histocompatibility complex (MHCs) were developed. To confirm the applicability of the model to clinical settings, the prediction models were comprehensively validated by a series of analyses. The validated prediction models used a flexible transfer learning approach and differential learning schema to achieve highly accurate prediction of TCR binding specificity only using TCR sequence data, antigen sequence data, and MHC alleles.

Abstract: The present invention relates to an anti-4-1BB-anti-PD-L1 bispecific antibody, and a pharmaceutical composition and the use thereof. Specifically, the present invention relates to a bispecific antibody, which comprises a first protein functional region targeting 4-1BB and a second protein functional region targeting PD-L1 or PD-1, wherein the first protein functional region is a single-domain antibody against 4-1BB; and the second protein functional region is an anti-PD-L1 antibody, anti-PD-1 antibody, anti-CTLA-4 antibody or anti-HER-2 antibody, or an antigen-binding fragment thereof. The bispecific antibody has the function of blocking the binding of PD-L1 to a receptor PD-1, and binds to 4-1BB on an immune cell, such that the immune cell activity in a tumor microenvironment is activated and the effect of inhibiting tumor occurrence and development is improved more effectively.

Abstract: An aircraft control system and control method are disclosed. The system comprises a remote control apparatus with a first control rod and a flight controller associated with an aircraft. The first control rod is configured to move in a first movement direction to control a motion of the aircraft in a first motion direction when an external force is applied on the first control rod and after a withdrawal of the external force, the first control rod returns to a preset position. The remote control apparatus operates to generate one or more control signals corresponding to the withdrawal of the external force. The flight controller controls the aircraft to maintain a flight state based on said control signals and one or more state signals, which are generated based on a measurement of the flight state by a flight controller associated with the aircraft state measurement sensors carried by the aircraft.

Abstract: The present disclosure provides a product for preventing the deterioration of an adhesive layer and a method for manufacturing the product. The product comprises a first product housing, a second product housing, an adhesive layer, and a protective layer. The second product housing is opposite to the first product housing. A gap exists between the second product housing and the first product housing. The adhesive layer is disposed in the gap between the first product housing and the second product housing, adhering to the first product housing and the second product housing. The protective layer is disposed on the adhesive layer. The protective layer is disposed in the gap, covering the outer surface of the adhesive layer. The protective layer bonds and cross-links to the adhesive layer chemically.

Abstract: A dynamic link library loading method includes: when an identifier of a first dynamic link library is not in a list of loaded dynamic link libraries, allocating a handle to the first dynamic link library, and adding the identifier of the first dynamic link library and the handle allocated to the first dynamic link library to the list of the loaded dynamic link libraries; and when the first dynamic link library is an integrated dynamic link library, adding identifiers of one or more dynamic link libraries for integration and the handle allocated to the first dynamic link library to the list of loaded dynamic link libraries; and based on the handle allocated to the first dynamic link library, loading the first dynamic link library into a running memory of an electronic device.

Abstract: A site effect simulator, including a site effect simulator base plate, where counter-force pillars are vertically arranged at diagonals of the site effect simulator base plate, the counter-force walls are connected to counter-force pillars along two sides of the site effect simulator base plate, a plurality of single-layer soil boxes are arranged at the inner side of the site effect simulator base plate, wave-absorbing materials are arranged inside single-layer soil boxes, and sliding panels are arranged at an upper side and a lower side of each single-layer soil box. The present disclosure does not need to rely on other counter-force frames, has the characteristics of flexible use, and can be randomly placed, and the height can be adjusted randomly. With a servo hydraulic actuator with three directions and six degrees of freedom, seismic simulation tests can be realized independently.

Abstract: Control of a mobile device is transferred to and from an operator. In one aspect, a specification for triggering manual control of the mobile device is accessed. A location is identified within a geographic region that exhibits characteristics defined by the specification. The location is represented in a navigation map and is associated with an operator trigger. As the mobile device approaches the location, a request for manual control is provided to the operator based on the operator trigger, and manual control is initiated.

Abstract: The present disclosure relates to a shimming device. The shimming device may include at least one supporting component each of which is configured with a plurality of wire groove groups. Each of the plurality of wire groove groups may include a plurality of wire grooves. Each of the plurality of wire grooves may be in a closed shape. The closed shapes formed by the plurality of wire grooves may be nested. The shimming device may further include wires arranged in the wire grooves of the plurality of wire groove groups of the at least one supporting component.

Abstract: An asynchronous rolling mill with a super large diameter ratio comprises a rolling mill stand, a press-down device, a balancing device, an upper roll system, and an arc-shaped plate device. The arc-shaped plate device comprises an arc-shaped plate, the arc-shaped plate is arranged opposite to the upper roll, and the arc-shaped plate and the upper roll are cooperated to roll strips. The present disclosure also provides a method for rolling a strip using an asynchronous rolling mill with a super large diameter ratio. The asynchronous rolling mill can roll with super large diameter ratio and different speeds, and has a large angle to engage, thereby reducing the external friction force of a workpiece and improving strip forming quality.

Abstract: The present disclosure concerns a device for forming a multi-flavor composite structure filter rod in one step, including the following components: a tow transmission belt, a tow guiding horn-shaped mouth, a tow assembly paper collection groove, a cigarette lap adhesive applying device and multi-flavor adding devices. According to shapes and types of flavors, the multi-flavor adding devices are arranged in different sections to obtain one-step formation of the multi-flavor composite structure filter rods. The present disclosure also discloses a one-step method of forming the multi-flavor composite structure filter rod using the one-step forming device.

Abstract: An organic light-emitting material containing cyano-substituted ligand is disclosed. The organic light-emitting material is a metal complex containing a cyano-substituted ligand, which can be used as a light-emitting material in a light-emitting layer of an organic electroluminescent device. These new complexes can provide better device performance, e.g., narrower full width at half maximum, lower voltage values, and higher quantum efficiency, and the like. An electroluminescent device and a compound formulation containing the metal complex, and a compound capable of being used to prepare the metal complex are also disclosed.