Abstract: A battery system includes a rechargeable energy storage system (RESS) having battery cells, and a battery controller network configured to execute two-level logic to detect a thermal runaway condition. The network includes RESS-embedded cell monitoring units (CMUs) electrically connected to a respective cell group, and measuring and wirelessly transmitting cell data. A battery control module (BCM) is in communication with the CMUs. Thermal runaway sensors are mounted on the CMUs and/or the BCM. A master controller connected to the BCM includes a thermal runaway detection algorithm configured to detect a thermal runaway condition occurring within the RESS. The BCM uses data from the CMUs and thermal runaway sensors to execute first logic level which determines when to wake up the master controller. The master controller, in response to receipt of a wakeup signal, executes a second logic level to execute the algorithm.

Abstract: A node configured to operate in a network that operates one or more of Internet Protocol version 6 (IPv6) and Segment Routing over IPv6 (SRv6), the node includes circuitry configured to determine a packet is to be sent to a second node in the network, with both the node and the second node utilizing Reduced Mode micro-Segment Identifiers (uSIDs), and include an identifier in an IPv6 header of the packet denoting a destination address of the packet includes uSIDs. The circuitry can be further configured to include the identifier responsive to a determination the second node supports the identifier.

Abstract: The disclosure provides crystalline forms for certain synthetic intermediates for making belzutifan, a HIF-2? inhibitor, useful for the treatment of cancer. The disclosure also provides processes for isolating the crystalline forms.

Abstract: A method for forming a test flume usable in hydraulic engineering and debris-flow hazard mitigation is provided. The test flume has a foundation flume and an expansion flume. The expansion flume has a lower edge connected to an upper edge of the foundation flume. A hydraulic radius of the test flume is determined based on a model test. A width of the foundation flume is selected based on a size of the test site of the model test. A coefficient is obtained and a width of the test flume is obtained. A cross section curve equation of the expansion flume is obtained based on the hydraulic radius of the test flume, the coefficient, the width of the test flume and the width of the foundation flume. The test flume is formed based on the cross section curve equation of the expansion flume.

Abstract: A rigid-flexible coupling-driven robot for removing oxide scales on super large shaft forgings online includes a heavy-duty manipulator main body, four walking systems, a movable arm lifting system, a clamping system, a power system, two oxide scale removal systems and a visual identification system. The two oxide scale removal systems are respectively installed on the two trapezoidal plates of the clamping system. Each of the two oxide scale removal systems adopts rigid-flexible coupling drive technology, that is, the rigid drive of the overhead hydraulic cylinder, cable-stayed hydraulic cylinder, the long stroke scissor retractable bracket and the rack and pinion device is combined with the flexible drive of the wire rope, so that the retraction and the angle tilt of the parallelogram end removal device are realized, which makes the oxide scale removal more flexible and efficient, thus greatly improving the product quality of large forgings.

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: In a method for treating waste water containing ammonium salts, sodium sulfate crystal is obtained by freezing crystallization, then the pH value of the waste water is adjusted to a specific range, and next sodium chloride crystal and ammonia water is obtained by evaporation. Alternatively, the pH value of the waste water is adjusted to a specific range, then sodium chloride crystal and ammonia water is obtained by evaporation, and next sodium sulfate crystal is obtained by freezing crystallization. This method can recover ammonia, sodium sulfate, and sodium chloride from the waste water.

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

Abstract: A hydraulically controlled backing roller includes a mandrel, two cover plates which are installed at two ends of the mandrel through screws respectively, and two screwdown gears which are installed at two end portions of the mandrel respectively. The two screwdown gears are engaged with an output rack of a screwdown hydraulic cylinder, multiple saddle ring sets are sleeved on the mandrel at equal intervals, a saddle ring of each of the saddle ring sets is fixed with a frame through a fan-shaped plate, a backing bearing is provided between two adjacent saddle ring sets; an inner eccentric ring of the each of the saddle ring sets is driven to rotate by hydraulic driving, so that the mandrel has a deflection deformation, and the deflection deformation is transmitted to other adjacent rollers through the backing bearing.

Abstract: A rolling device capable of applying horizontal vibration for metal clad plates includes two symmetrically arranged support frames, an upper roller and a lower roller both of which are provided between the two support frames and parallel to each other, four bearing seats which are fixed with two ends of the upper roller and two ends of the lower roller respectively, and four horizontal vibration apparatuses which are provided outside the four bearing seats respectively for driving the upper roller and the lower roller to horizontally vibrate. Every horizontal vibration apparatus includes an exciting hydraulic cylinder and a damper. One end of the exciting hydraulic cylinder and one end of the damper are fixedly connected with two sides of one of the four bearing seats respectively. Every horizontal vibration apparatus is provided outside one of the four bearing seats.

Abstract: The present disclosure concerns a device for forming a multi-flavor composite structure filter rod in one step, including the following components: a tow transmission belt, a tow guiding horn-shaped mouth, a tow assembly paper collection groove, a cigarette lap adhesive applying device and multi-flavor adding devices. According to shapes and types of flavors, the multi-flavor adding devices are arranged in different sections to obtain one-step formation of the multi-flavor composite structure filter rods. The present disclosure also discloses a one-step method of forming the multi-flavor composite structure filter rod using the one-step forming device.

Abstract: Disclosed in the present invention is a prevention and control method of nitrogen protection and multi-region level-by-level detection for an energy storage power station. The prevention and control method of nitrogen protection and multi-region level-by-level detection for an energy storage power station includes two modes: a normal operating mode and an abnormal mode. In the two modes, fire extinguishing measures of different levels are adopted for a battery pack, a battery cluster, a battery compartment, and a device compartment with reference to early warning thresholds of different levels. Further disclosed is a prevention and control system of nitrogen protection and multi-region level-by-level detection for an energy storage power station.

Abstract: A tank is secured under the keel of a floating structure for offshore energy development. The tank is filled with ballast material that supplements or replaces the ballast already present on the floating structure, thereby gaining larger topsides payload capacity for the floating structure or increasing stability and motion performance of the floating structure.

Abstract: A method for reducing the negative effect of heat acclimatization for the hatching of a poultry hatching egg is provided. A special light source is used as an ambient light to hatch the poultry hatching egg. The special light source is light-emitting diode (LED) monochromatic blue light with a light intensity of 20 lux to 50 lux and a wavelength of about 450 nm, such that the light can reduce the negative effect of heat acclimatization at a hatching stage of the poultry hatching egg. The method can reduce the levels of oxidation products such as malondialdehyde (MDA) and corticosterone in a chicken embryo during heat acclimatization at the hatching stage of the poultry hatching egg and increase the expression levels of antioxidase and heat shock protein (HSP) genes, and the special light source reduces the metabolic heat production of the chicken embryo.

Abstract: A temperature demodulation method oriented toward a distributed fiber Raman temperature sensing system, the method comprising the following steps: step 1 of constructing a high-precision temperature detection device oriented towards a distributed fiber Raman sensing system; step 2 of performing signal processing with respect to Stokes light and anti-Stokes light at a calibration stage; step 3 of performing signal processing with respect to Stokes light and the anti-Stokes light at a measurement stage; and step 4 of obtaining a high-precision temperature demodulation technique oriented toward the distributed fiber Raman sensor. The method is used to effectively resolve the issue of low temperature measuring accuracy caused by Rayleigh crosstalk in existing distributed fiber Raman temperature measurement systems, and temperature measurement accuracy thereof is expected to fall within ±0.1° C. The method is applicable to distributed fiber Raman temperature measurement systems.

Abstract: An unmanned aerial vehicle (UAV) includes one or more processors individually or collectively configured to assess a location of the UAV, calculate a distance between the UAV and a flight-restricted region using the location of the UAV, assess whether the distance falls within a first distance threshold, and instruct the UAV to take a flight response measure selected from (1) a first flight response measure when the distance falls within the first distance threshold, and (2) a second flight response measure different from the first flight response measure when the distance falls outside the first distance threshold. The first flight response measure at least includes causing the UAV to descend or hover over a location. A rate at which the UAV descends is determined based on the location of the UAV.

Abstract: Neoantigens play a key role in the recognition of tumor cells by T cells. However, only a small proportion of neoantigens truly elicit T cell responses, and fewer clues exist as to which neoantigens are recognized by which T cell receptors (TCRs). To help determine the TCRs that interact with particular neoantigens, prediction models that predict TCR-binding specificities of neoantigens presented by different classes of major histocompatibility complex (MHCs) were developed. To confirm the applicability of the model to clinical settings, the prediction models were comprehensively validated by a series of analyses. The validated prediction models used a flexible transfer learning approach and differential learning schema to achieve highly accurate prediction of TCR binding specificity only using TCR sequence data, antigen sequence data, and MHC alleles.

Abstract: The present invention relates to an anti-4-1BB-anti-PD-L1 bispecific antibody, and a pharmaceutical composition and the use thereof. Specifically, the present invention relates to a bispecific antibody, which comprises a first protein functional region targeting 4-1BB and a second protein functional region targeting PD-L1 or PD-1, wherein the first protein functional region is a single-domain antibody against 4-1BB; and the second protein functional region is an anti-PD-L1 antibody, anti-PD-1 antibody, anti-CTLA-4 antibody or anti-HER-2 antibody, or an antigen-binding fragment thereof. The bispecific antibody has the function of blocking the binding of PD-L1 to a receptor PD-1, and binds to 4-1BB on an immune cell, such that the immune cell activity in a tumor microenvironment is activated and the effect of inhibiting tumor occurrence and development is improved more effectively.

Abstract: An aircraft control system and control method are disclosed. The system comprises a remote control apparatus with a first control rod and a flight controller associated with an aircraft. The first control rod is configured to move in a first movement direction to control a motion of the aircraft in a first motion direction when an external force is applied on the first control rod and after a withdrawal of the external force, the first control rod returns to a preset position. The remote control apparatus operates to generate one or more control signals corresponding to the withdrawal of the external force. The flight controller controls the aircraft to maintain a flight state based on said control signals and one or more state signals, which are generated based on a measurement of the flight state by a flight controller associated with the aircraft state measurement sensors carried by the aircraft.