Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: A method for processing clock drift implemented by a first network element includes: receiving a first notification message transmitted by a second network element, the first notification message including a first clock difference between a first clock domain and a second clock domain acquired by the second network element, transmission of the first notification message being triggered by a clock drift between the first clock domain and the second clock domain being greater than a drift amplitude value, which is a maximum value of a change amplitude of a clock difference between the first and second clock domain; determining first time sensitive communication assistance information (TSCAI) according to the first clock difference; and transmitting the first TSCAI to a radio access network (RAN) device, the first TSCAI being used by the RAN device to perform time control on a data stream in the first clock domain.

Abstract: A dynamic link library loading method includes: when an identifier of a first dynamic link library is not in a list of loaded dynamic link libraries, allocating a handle to the first dynamic link library, and adding the identifier of the first dynamic link library and the handle allocated to the first dynamic link library to the list of the loaded dynamic link libraries; and when the first dynamic link library is an integrated dynamic link library, adding identifiers of one or more dynamic link libraries for integration and the handle allocated to the first dynamic link library to the list of loaded dynamic link libraries; and based on the handle allocated to the first dynamic link library, loading the first dynamic link library into a running memory of an electronic device.

Abstract: The present disclosure provides a smart automatic frequency control (AFC) apparatus, including: a phase shift module, connected to a first signal input terminal and configured to: receive an incident wave from the first signal input terminal, perform a phase shift on the incident wave according to a phase shift parameter so as to generate a phase-shifted signal, and output the phase-shifted signal to a phase detection module; and the phase detection module, connected to the phase shift module and a second signal input terminal and configured to: receive a reflected wave from the second signal input terminal, perform a phase detection on the phase-shifted signal and the reflected wave so as to generate a phase difference signal, and output the phase difference signal via a control interface.

Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.

Abstract: A power converter incudes a power factor correction circuit and a controller. The power factor correction circuit is configured to convert an input single-phase electrical power to a first DC electrical power. An active phase of the input single-phase electrical power is received in parallel through two of four conductors. A return phase of the input single-phase electrical power is received in parallel through two others of the four conductors. The power factor correction circuit is also configured to convert an input three-phase electrical power to the first DC electrical power. Three active phases of the input three-phase electrical power are received through three of the four conductors. The return phase is received through a fourth of the four conductors. The controller is configured to control the power factor correction circuit to operate in the single-phase input mode and the three-phase input mode in response to a control signal.

Abstract: The present disclosure provides a display panel and a display device. The display panel includes: a substrate; and a light-emitting device and a packaging structure on the substrate, the packaging structure sealing the light-emitting device on the substrate. The light-emitting device includes a cathode, an anode, and a light-emitting layer between the cathode and the anode; the packaging structure includes a first inorganic packaging layer, and the first inorganic packaging layer includes a first inorganic packaging sublayer, a second inorganic packaging sublayer, and a third inorganic packaging sublayer that are sequentially stacked; and a refractive index of the second inorganic packaging sublayer is greater than a refractive index of the first inorganic packaging sublayer, and a difference between the refractive index of the second inorganic packaging sublayer and the refractive index of the first inorganic packaging sublayer is greater than 0.

Abstract: Provided is an ice avalanche-type glacial lake outburst surge generation and height measurement device. A glacial lake outburst test device includes a glacial lake simulation module and an ice avalanche surge module. An impact path, an impact angle, an impact scale, an impact velocity and a landslide density of an ice avalanche slider are controlled by simulation means. During formation of ice avalanche surges, the ice avalanche slider rushes into the glacial lake at a high speed, an ice avalanche pushes water to move in a sliding direction, thus forming a first surge, then continues to move to the bottom of the lake under the inertia and discharges a certain amount of water at its back. Movement of the landslide drives surrounding water to converge quickly into the back area, thus forming a second surge. Surge waves evolve around with a water entry point as a center.

Abstract: Arginase 1 binders comprising human antibodies and antigen-binding fragments thereof that inhibit the activity of human Arginase 1 (hArg1) are described. These Arginase 1 binders present an alternative mechanism for inhibiting hArg1 activity and highlight the ability to utilize binders as probes in the discovery and development of peptide and small molecule inhibitors for enzymes in general.

Abstract: A multi-source coupling system for household energy storage includes an energy gateway configured to control coupling and decoupling of different power sources; an energy storage system coupled to the energy gateway and configured to store electrical energy; and a power conversion system coupled to the energy gateway and configured to convert the different power sources into current sources or voltage sources.

Abstract: The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.

Abstract: The invention belongs to the technical field of metal micro-forming, and in particular relates to a method for inflating micro-channels. The present invention is aimed at the problems of low process flexibility, single product type, and non-closed structure of the micro-channel when preparing metal micro-channels by micro-plastic forming of ultra-thin metal strips. The present invention uses a method combining numerical simulation and bond rolling experiment to analyze the effect of the hydrogen pressure and bond strength of the metal composite ultra-thin strip after bond rolling on the pore diameter of the micro-channel, and the corresponding relationship between the micro-channel pore diameter and the titanium hydride content, heating temperature, and bond strength of the metal composite ultra-thin strip is obtained.

Abstract: The present invention provides an information processing system that can process processing target information while confidentiality of the processing target information is retained. An information processing system 1 includes a first encrypted information generation unit 110 that is provided to the first information terminal 11 and that generates first encrypted information as information resulting from encryption of each of plural pieces of processing target information, a second encrypted information generation unit 120 that is provided to the second information terminal 12 and that generates second encrypted information as information processed without decrypting plural pieces of first encrypted information, and a decryption processing unit 111 that is provided to the first information terminal 11, decrypts the second encrypted information, and acquires the processing result information.

Abstract: A method implemented by a node in a network utilizing Multiprotocol Label Switching (MPLS) includes performing a convergence procedure to discover the topology of a network in which multiple nodes are arranged; and upon determining that the topology of the network is a ring topology whereby the node is connected to two neighboring nodes by a respective link, creating a first table for a first link, the first table including labels representing at least a portion of a label stack for allowing the node to transmit packets to another node in the network in a clockwise (CW) direction around the ring; and creating a second table for a second link, the second table including labels representing at least a portion of a label stack for allowing the node to transmit packets to another node in the network in an anti-clockwise (ACW) direction around the ring.

Abstract: This disclosure includes a polymer blend comprising. The polymer blend includes at least 60% by weight olefin-based polymer, and a diblock copolymer comprising an non-polar block and a polar block, wherein the diblock copolymer has a number average molecular weight number (Mn) less than 5000 g/mol as determined by proton nuclear magnetic resonance (1H NMR); and wherein the non-polar block and the polar block are connected by a thiol linkage.

Abstract: An asynchronous rolling mill with a super large diameter ratio comprises a rolling mill stand, a press-down device, a balancing device, an upper roll system, and an arc-shaped plate device. The arc-shaped plate device comprises an arc-shaped plate, the arc-shaped plate is arranged opposite to the upper roll, and the arc-shaped plate and the upper roll are cooperated to roll strips. The present disclosure also provides a method for rolling a strip using an asynchronous rolling mill with a super large diameter ratio. The asynchronous rolling mill can roll with super large diameter ratio and different speeds, and has a large angle to engage, thereby reducing the external friction force of a workpiece and improving strip forming quality.

Abstract: Disclosed herein is a light-gauge, ultra-high strength weathering steel pile for use as a steel foundation in structures such as, for example, solar arrangements. The light-gauge, ultra-high strength weathering steel pile comprises a thickness of 2.5 mm or less that has been cold roll formed into a steel pile having a web and a pair of opposing flanges, each having discontinuities formed therein. The steel pile further comprises a yield strength of between 700 and 1600 MPa, a tensile strength of between 1000 and 2100 MPa, and an elongation of between 1% and 10%.

Abstract: The present invention relates to a variable-flow-path air valve for water hammer prevention and a design method. The variable-flow-path air valve includes a valve body with a top provided with an air intake-exhaust port. A ball valve seat and a floating ball are arranged below the air intake-exhaust port. The valve body is provided with at least one swing check valve configured to be opened inward. The swing check valve includes: a swing valve disc connected to a valve body hinge, a variable-flow-path air inlet controlled by the swing valve disc to open and close, a device for limiting the opening degree of the swing valve disc, and a sealing device. In the present invention, the air valve takes in air through the air intake-exhaust port and the variable flow path, and discharges air only through the air intake-exhaust port.

Abstract: A pulse current processing apparatus includes a bidirectional tension and pulse current application apparatus, a real-time thin metal strip shape detection apparatus and a supporting base. In the apparatus, the tension is applied in the rolling direction and the transverse direction to effectively improve the strip shape flaws of the thin metal strip, and realize the rapid straightening of the thin metal strip; at the same time, the stress status of the thin metal strip is changed by applying the pulse current along the rolling direction or the transverse direction or applying different tensions in two directions; secondly, compared with the conventional heat-preservation heating and annealing apparatus, the pulse current can realize high-efficiency control of mechanical properties of the thin metal strip, and rapidly eliminate the internal stress; further, the strip shape is monitored by the laser ranging to ensure the strip shape consistency of the thin metal strip.

Abstract: A device includes a transceiver, a receiver, and a processor. The transceiver is configured to receive feedback data from an unmanned aerial vehicle (UAV) and transmit control data to the UAV via a first communication link. The receiver is configured to receive the control data from a controlling terminal via a second communication link. The second communication link does not interfere with the first communication link. The processor is configured to determine whether the feedback data and the control data are being simultaneously transmitted via the first communication link.