Abstract: An industrial visual stethoscope system and a detecting method are provided. The system has a base, a workpiece support, a single-color lighting device, a camera module, a rotating device, and an analyzing device. When the single-color light irradiates the workpiece, if the single-color light irradiates into the crack which is relatively deep and narrow, the single-color light is rarely to be reflected out of the crack. But if the single-color light irradiates into the scar, the single-color light is reflected out of the scar due to the specular reflection. During the relative rotation, when the reflected light enters the camera module in parallel, the energy of the light is concentrated, causing overexposure and forming obvious white light. Thus, the analyzing device can identify the recess is a scar formed by hit rather than a crack formed by heat.

Abstract: The present invention relates to Spirocyclic Pyridotriazine Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R16 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Pyridotriazine Derivative, and methods of using the Spirocyclic Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.

Abstract: The present invention relates to Amido-Substituted Pyridotriazine Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, R, R1, R2 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyridotriazine Derivative, and methods of using the Amido-Substituted Pyridotriazine Derivatives for treating or preventing HIV infection in a subject.

Abstract: Disclosed in the present invention are a crystalline Form of pyrido[1,2-a]pyrimidone analog, a preparation method therefor and an intermediate thereof,

Abstract: The present disclosure provides a virus signature matching method, including: obtaining an inputted target file; loading a virus signature database, and successively extracting signature function identifiers from the virus signature database, the virus signature database comprising the signature function identifiers and virus signature type identifiers corresponding to the signature function identifiers; obtaining signature functions corresponding to the signature function identifiers, and checking the target file by invoking the signature functions, to obtain corresponding check results; and obtaining a virus signature type identifier corresponding to the target file according to the check results. In addition, a virus signature matching apparatus is further provided. The foregoing virus signature matching method and apparatus can improve virus scanning and removing efficiency.

Abstract: One aspect of the invention relates to a series of new PCSK9 inhibitor compounds comprising piperidine ring structures, including compounds of formula (I) and/or pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating PCSK9 receptor related diseases comprising administration of one or more compounds of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: There are provided a driving method of a display panel and a driving module, a display panel and a display apparatus, which are capable of reducing power consumption of the display panel. The driving method of the display panel comprises: determining positions of gate lines to be scanned; determining offset current values according to the positions of the gate lines to be scanned; and generating driving signals of GOA units corresponding to the gate lines to be scanned according to the offset current values and clock signals of the display panel. The driving method of the display panel and the driving module, the display panel and the display apparatus determine the offset current values according to the positions of the gate lines to be scanned, and the amplitude of the offset current values only needs to ensure the normal display of the display panel when the gate lines to be scanned are scanned, thereby power consumption of the display panel is reduced.

Abstract: A routing system may include a primary message group to be used for synchronizing stored information. The primary message group may include multiple primary network devices. The multiple primary network devices may be configured with a first configuration regarding synchronizing the stored information. The primary message group may form a ring network topology. The routing system may include a secondary message group to be used for synchronizing the stored information. The secondary message group may include a single primary network device, of the multiple primary network devices, and multiple secondary network devices. Each secondary network device, of the multiple secondary network devices, may be included in a single secondary message group. The multiple secondary network devices may be configured with a second configuration regarding synchronizing the stored information. The secondary message group may form a different ring network topology.

Abstract: The present invention relates to Phosphate Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Phosphate Substituted Quinolizine Derivative, and methods of using the Phosphate Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

Abstract: The techniques described herein relate to methods, apparatus, and computer readable media configured to decode modulated data. A modulated signal is received. A format of the modulated signal is determined, wherein the format can include a first format comprising a first type of modulated signal, or a second format comprising the first type of modulated signal and a second type of modulated signal that is different than the first type. The modulated signal is decoded by determining a frequency shift amount based on the format of the modulated signal, shifting a frequency band of the first type of modulated signal from an original position to a shifted position, thereby shifting a center frequency of the first type of modulated signal by the frequency shift amount, and filtering, based on the format of the modulated signal, signals outside of the frequency band of the shifted first type of modulated signal.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: A load management system for reducing engine lug during transient conditions is disclosed. The load management system may include a driven component, a power source configured to drive the driven component, and a controller in communication with the driven component and the power source. The controller may be configured to: monitor a current intake manifold pressure of the power source and a current load of the driven component, calculate a ratio based on the current intake manifold pressure and a steady state intake manifold pressure of the power source, and start a predetermined time period based on the ratio and the current load during which the power source builds up power to respond to the current load.

Abstract: The present disclosure relates to an electronic device, display device and method for manufacturing a display device. The display device includes: a flexible OLED layer having at least one edge comprising a curved section and a first body section and a second body section connected at two ends of the curved section, wherein the first body section is located adjacent to a front side of the display device, while the second body section is located far away from the front side of the display device; and a drive chip provided on the second body section.

Abstract: A crawling device is used for surrounding a cylinder and crawling along the extension direction of the mentioned cylinder. The kind of crawling device may include at least two-nodes crawling modules, a telescopic mechanism, and a control circuit. The telescopic mechanism connects with two-nodes crawling modules, and the crawling modules have an elastic mechanism and a drawstring respectively. In creeping movement, the at least two-nodes crawling modules are set in turn that one crawling module as a fixed section and the other crawling module as a mobile section. When the crawling module is set as a fixed section, the crawling module adjusts the drawstring through the elastic mechanism to make the fixed section close to the cylinder. Producing friction by keeping close to the cylinder let the fixed section maintain the fixed state relatively close to the cylinder.

Abstract: The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, m, R1, R2, R3, R3, R3, R4, R5 and R9 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject.

Abstract: Embodiments of the present invention provide a method and apparatus for processing advertisement data, and a storage medium. The method includes: executing the following steps in a browser application: obtaining a jump web page link of delivery data to be loaded, where the jump web page link includes a uniform resource locator of a data delivery platform website and identification information of the delivery data; sending delivery data loading request according to the jump web page link, so as to load and present a web page of the delivery data; detecting a loading completion status of jumping from the jump web page link to an arrival web page link including the identification information; and storing the jump web page link, the arrival web page link, and information about the loading completion status in an association.

Abstract: A fiber mat includes a unitary assembly of fibers including at least a first set of fibers and at least a first binder comprising an organic resin, wherein the unitary assembly of fibers includes a minority portion and a majority portion different than the minority portion, wherein the fiber mat provides at least a 5% increase in tear when placed in a bituminous roofing product compared to an equivalent bituminous roofing product made with a fiber mat of equivalent weight containing a homogenous mat structure.

Abstract: Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.

Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I). and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and R7 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.