Abstract: Surface conjugated diamagnetic Chemical Exchange Saturation Transfer (diaCEST) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based MRI contrast agents that are often toxic and therefore not biocompatible. The carriers described herein can provide simultaneous monitoring of multiple particle types labeled with ‘multicolor’ diaCEST contrast agents. In some embodiments, the carriers are micro- and/or nanoparticles. In other embodiments, the carriers are liposomes. In some embodiments, the particles and/or liposomes are mucus penetrating. In other embodiments, the particles and/or liposomes are not mucus penetrating.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

Abstract: A composite reinforcement includes a first nonwoven mat. A laid scrim overlies the first nonwoven mat, the laid scrim including a first plurality of yarns substantially oriented in a first direction and a second plurality of yarns substantially oriented in a second direction different from the first direction. The second plurality of yarns includes at least one different material from the first plurality of yarns and each of the yarns in the second plurality of yarns includes a tension greater than a tension of each of the yarns in the first plurality of yarns. A second nonwoven mat overlies the laid scrim, and a binder laminates the first nonwoven mat, the laid scrim, and the second nonwoven mat together to form the composite reinforcement.

Abstract: A tank liquid depth measurement method includes the steps of: a) providing a sensor capable of detecting a liquid pressure, b) providing a main unit for receiving data from the sensor, c) mounting the sensor under the liquid level in a water tank and mounting the main unit in the car, d) initiating the sensor and the main unit so as to cause the sensor to measure the internal liquid pressure and to enable the main unit to store the identification code and communication code of the sensor, and e) enabling the main unit to receive data from the sensor for matching and recording. By means of the operation of the sensor to transmit the detected data to the main unit for warning or informing the driver, the expected effects and objectives of the present invention are achieved.

Abstract: A chemically prepared toner composition according to one example embodiment includes a core including a first polymer binder, a second polymer binder, a colorant and a release agent; a shell that is formed around the core and includes a third polymer binder; and a borax coupling agent between the core and the shell. The first and third polymer binders are different amorphous polyester resins. The second polymer binder is a crystalline polyester resin and acts as a plasticizing agent in the core. The borax coupling agent assists in adhering the shell to the outer surface of the core. Optionally, the toner of the present invention may be finished with a set of extra particulate additives.

Abstract: The present invention provides a power-cable ground current self-adaptive monitoring method. The steps including configuring a sample baseline, determining an impact factor set of the sample data, sampling real-time data of ground current by a power-cable ground current monitoring system, perform digital filtering on the sampled real-time data of ground current, applying a self-adaptive method to process the filtered sample data, and uploading the processed sample data to a backend monitoring device for real-time monitoring. The present invention may solve high energy loss and low information amount problems. The power consumption of monitoring device may be reduced by more than 50%, and server resource occupancy percentage may be lowered by about 20%. Efficiencies of evaluating external insulation status of the are enhanced.

Abstract: A load management system for reducing engine lug during transient conditions is disclosed. The load management system may include a driven component, a power source configured to drive the driven component, and a controller in communication with the driven component and the power source. The controller may be configured to: monitor a current intake manifold pressure of the power source and a current load of the driven component, calculate a ratio based on the current intake manifold pressure and a steady state intake manifold pressure of the power source, and start a predetermined time period based on the ratio and the current load during which the power source builds up power to respond to the current load.

Abstract: Embodiments of the present invention relate to methods and apparatuses for enabling cluster scaling. Specifically, there is disclosed a method of recording a context of configuration for an initial node of a cluster, comprising: retrieving at least one file to be used for configuring the initial node; and recording a context while configuring the initial node using the at least one file, the recorded context being information on the configuration of the initial node and to be used for enabling addition of a new node into the cluster. There is also disclosed a method of enabling addition of a new node into a cluster. Corresponding apparatuses are also disclosed. According to embodiments of the present invention, the efficiency of improving cluster scaling may be effectively improved.

Abstract: Provided in the present invention is a genetic construct having a structure as represented by 5?-A+B+C+D+E-3?, wherein A indicates a promoter; B indicates a coding sequence of a fusion protein consisting of a target protein and a first labeled protein; C indicates a coding sequence of a connecting peptide; D indicates a coding sequence of a second labeled protein; and E indicates a terminator. Also provided in the present invention is a polypeptide having a structure as represented by B1+C1+D1, wherein B1 indicates the fusion protein consisting of the target protein and the first labelled protein; C1 indicates the connecting peptide; and D1 indicates a second labelled protein. Also provided in the present invention are a vector containing the genetic construct, a mammalian cell containing the genetic construct or the vector, a library consisting of the cell and a method for detecting protein stability and uses thereof.

Abstract: Processes and C/D box small nucleolar RNAs (snoRNAs) for altering telomerase activity and altering telomerase length are described. The processes of the invention involve the use of C/D box snoRNAs for targeted 2?-O-methylation modification of nucleotides in a pseudoknot region of the telomerase RNA. Depending on their position, the 2?-O-methylation modifications can cause an increase in telomerase activity and subsequent telomere lengthening or a decrease in telomerase activity and subsequent telomere shortening.

Abstract: An EEPROM device, a forming method thereof, and a method for implementing an erase operation to the device are provided. The EEPROM device includes: a semiconductor substrate having active regions therein; a word line disposed on a first active region; float gate dielectric layers disposed on second active regions; float gates disposed on the float gate dielectric layers, wherein each of the float gates has a width larger than that of the second active region; control gates disposed on control gate dielectric layers which are disposed on the float gates; an isolation oxide layer disposed between the word line and the float gates along with the control gates; and bit line doping regions disposed on third active regions. Accordingly, an erase operation can be implemented from a bit line, and coupling ratios of a float gate to a control gate and to a bit line doping region can be improved.

Abstract: Embodiments of the present invention relate to methods and apparatuses for enabling cluster scaling. Specifically, there is disclosed a method of recording a context of configuration for an initial node of a cluster, comprising: retrieving at least one file to be used for configuring the initial node; and recording a context while configuring the initial node using the at least one file, the recorded context being information on the configuration of the initial node and to be used for enabling addition of a new node into the cluster. There is also disclosed a method of enabling addition of a new node into a cluster. Corresponding apparatuses are also disclosed. According to embodiments of the present invention, the efficiency of improving cluster scaling may be effectively improved.

Abstract: Methods for affecting mRNA expression or translation through the modification of pre-mRNA or mRNA transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mRNA transcript is 2?-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript. In another embodiment, a uridine residue in a nonsense stop codon may be modified to pseudouridine, causing the translation machinery to read through the nonsense stop codon and translate a full length protein.

Abstract: Embodiments are directed towards a speaker/microphone system. Each microphone in a microphone array generate an audio signal based on sound in a physical space. The microphone array may be arranged to logically define the physical space into a plurality of regions that have a status of active or inactive. An output signal may be generated from the audio signals, such that directional noise reduction is performed on audio signals associated with inactive regions and speech enhancement is performed on audio signals associated with active regions. A region's current status may be modified to its opposite status based on a request provided by a user. The request may be triggered by an activator or a spoken word/phrase provided by the user. An indication may be provided to the user regarding each current status for each region. The indication may also represent a quality of audio signals associated with active regions.

Abstract: The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values.

Abstract: Provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant amines and (ii) an acid. Also provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant acids and (ii) an amine. The compositions are useful inter alia for chemical or oil spill cleanup, drug delivery systems, transparent films, adhesives, binding agents, conductors, membranes, cross-linking agents, or opticoelectronic applications. Also provided are methods for making the compositions of the invention, as well as a battery and a composition for controlled release of a compound, each comprising a composition of the invention.

Abstract: In a method and a device for clustering files of the present application, to cluster files to be processed, information fingerprints of the files to be processed are obtained by processing information fingerprints of features of a plurality of information blocks contained in the file to be processed and are compared, and files to be processed with the same information fingerprint are taken as one cluster, so as to realize the clustering of files. The features of the information blocks in the files to be processed are identified by means of information fingerprints in this way, and then clustering is performed according to identifiers. Compared to prior art method using similarity comparisons, the method and device of the present application, which calculate and cluster an identifier of a feature, greatly reduce the data to be calculated and the degree of complexity.

Abstract: The present invention relates to adaptive beamforming in audio systems. More specifically, aspects of the invention relate to a method for adaptively estimating a target sound signal by establishing a simulation model simulating an audio environment comprising: a plurality of spatially separated microphones, a target sound source, and a number of audio noise sources.