Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: Disclosed is a pyridino[1,2-a]pyrimidone analogue used as an mTOR/PI3K inhibitor. The present invention particularly relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure describes methods and apparatus for implementing a signature-based sleep recovery operation flow for booting a system-on-chip (SoC). When the SoC begins its normal boot flow, a controller retrieves a sleep recovery signature from a register and compares the retrieved sleep recovery signature to a default signature. If the sleep recovery signature matches the default signature, the SoC enters a ROM checksum fail debug flow and, upon satisfying the requirements of the ROM checksum fail debug flow, enters a sleep recovery boot flow, which restores the SoC to the operational state it was in prior to entering the sleep mode. If the sleep recovery signature does not match the default signature, the SoC continues with the normal boot flow or, by use of external pins, can be forced into a normal debug mode flow so that the boot code can be debugged.

Abstract: The present invention disclosed N-acetyl amino acid ester derivatives of betulin and the preparation method thereof, the method comprising the steps that in the presence of an alkaline substance, a catalyst and a racemization-inhibitor, the carboxyl group of N-acetyl amino acid is activated by a coupling agent; and then the activated N-acetyl amino acid is reacted with betulin via esterification reaction to obtain the N-acetyl amino acid ester derivative of betulin. The present invention provided a simple synthesis method to synthesize the N-acetyl amino acid ester derivatives of betulin by using betulin as a precursor compound and modifying the molecular structure of betulin. Such structural modification of betulin significantly enhances the anti-tumor activity of the betulin derivatives and therefore has important values.

Abstract: A server system capable of supporting a plurality of storage devices includes a rack, a server kit and a server slide rail. The server kit includes a holder and frame. The holder has a first zone and a second zone with different widths. The frame whereinside the storage devices are slidably assembled is disposed on the first zone. The server slide rail includes a rail supporting component, an external rail component and an internal rail component. The rail supporting component is disposed on the rack, and has a first part and a second part with different lengths. The external rail component is disposed on the second part and does not overlap the first part. The internal rail component is disposed on the second part and slidably assembled with the external rail component.

Abstract: A method of making a glass mat includes providing an assembly of glass fibers, applying a binder composition to the assembly of glass fibers, wherein the binder includes an organic resin, and curing the binder composition while dimensionally constraining the assembly of glass fibers. Dimensional constraining includes directly contacting a first major surface and a second major surface of the assembly of glass fibers between two substantially parallel surfaces. Further provided is a glass mat that includes an assembly of glass fibers, wherein the assembly of glass fibers are substantially randomly oriented with a tensile anisotropy of less than about 6 in any two directions. The glass mat has a decreased surface roughness and a decreased caliper compared to an equivalent glass mat having an assembly of naturally packed glass fibers with an equivalent fiber diameter size.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: A semiconductor assembly includes a semiconductor die comprising lower and upper electrical contacts. A lead frame having a lower die pad is electrically and mechanically connected to the lower electrical contact of the die. An upper conductive member has a first portion electrically and mechanically connected to the upper electrical contact of the die. A lead terminal has a surface portion electrically and mechanically connected to a second portion of the conductive member. The surface portion of the lead terminal and/or the second portion of the conductive member has a series of grooves disposed therein. Packaging material encapsulates the semiconductor die, at least a portion of the lead frame, at least a portion of the upper conducive member and at least a portion of the lead terminal.

Abstract: A glass mat is provided. The glass mat includes an assembly of glass fibers; and a binder composition including a polymer resin and a crosslinker. The polymer resin has a pH of at least about 5.0. The polymer resin includes a styrenic copolymer, an acrylic copolymer, or combination thereof having at least one functional group of a carboxylic acid, a salt of a carboxylic acid, an anhydride, a salt of an anhydride, or combination thereof. The crosslinker includes a polyol, a polyepoxy, a polycarbodiimide, a polyaziridine, a bivalent metal carbonate, or combination thereof. Further provided is a method of making the glass mat.

Abstract: A tank liquid depth measurement method includes the steps of: a) providing a sensor capable of detecting a liquid pressure, b) providing a main unit for receiving data from the sensor, c) mounting the sensor under the liquid level in a water tank and mounting the main unit in the car, d) initiating the sensor and the main unit so as to cause the sensor to measure the internal liquid pressure and to enable the main unit to store the identification code and communication code of the sensor, and e) enabling the main unit to receive data from the sensor for matching and recording. By means of the operation of the sensor to transmit the detected data to the main unit for warning or informing the driver, the expected effects and objectives of the present invention are achieved.

Abstract: The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R11 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Abstract: A method and system for placing database. The method includes: receiving a request of creating a new database; determining whether there is a need to migrate current database among current virtual machines based on resource demand and free resource in the current virtual machines; determining database placement plan based on the resource demand, migration strategy and migration cost associated with the migration strategy in response to whether there is a need to migrate the database; and executing the database placement plan. The invention can help a database service provider to optimize database layout in database provision through database migration.

Abstract: The present invention discloses a method and an apparatus for recommending a suspicious component in problem diagnosis for a cloud application. In the method, firstly a graph data model representing a hierarchical structure of the cloud application is constructed, wherein the graph data model comprises an application node representing the cloud application, a plurality of component nodes representing a plurality of components of the cloud application, and inter-node lines indicating inter-node relationships. Then real-time information of the cloud application is obtained, in response to detecting performance degradation of the cloud application. Impact degrees of the plurality of component nodes on the performance degradation of the cloud application is obtained based on the constructed graph data model and the obtained real-time information, and a suspicious component sequence is generated according to the impact degrees of the plurality of component nodes.

Abstract: The present disclosure provides a virus signature matching method, including: obtaining an inputted target file; loading a virus signature database, and successively extracting signature function identifiers from the virus signature database, the virus signature database comprising the signature function identifiers and virus signature type identifiers corresponding to the signature function identifiers; obtaining signature functions corresponding to the signature function identifiers, and checking the target file by invoking the signature functions, to obtain corresponding check results; and obtaining a virus signature type identifier corresponding to the target file according to the check results. In addition, a virus signature matching apparatus is further provided. The foregoing virus signature matching method and apparatus can improve virus scanning and removing efficiency.

Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

Abstract: The present invention discloses a novel DGAT1 inhibitor, especially the compound of formula (I) or a pharmaceutically acceptable salt thereof, preparation and pharmaceutical composition thereof, as well as their uses in the preparation of a medicament for the prevention and treatment of Familial hyperchylomicronemia (FCS), obesity, hyperlipoproteinemia or hypertriglyceridemia.

Abstract: Embodiments are directed towards enhancing speech and noise reduction for audio signals. Each of a plurality of microphones may generate a plurality of audio signals based on sound sensed in a physical space. One of the plurality of audio signals may be designated as a primary channel and each other audio signal of the plurality of audio signals may be designated as secondary channels. Acoustic echo cancellation is performed on the primary channel to generate an echo canceled signal. Noise reduction (e.g., employing a multi-microphone beamformer) is performed on the primary channel and the secondary channels to generate a noise reduced signal. In various embodiments, the noise reduction is performed in parallel with the acoustic echo cancellation. An enhanced audio signal may be generated based on a combination of the echo canceled signal and the noise reduced signal.

Abstract: One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.

Abstract: The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y, R1, R2, R3, R4, R5, R9 and R10 are as defined herein. The present invention also relates to compositions comprising at least one Substituted Quinolizine Derivative, and methods of using the Substituted Quinolizine Derivatives for treating or preventing HIV infection in a subject.

Abstract: A battery accommodating module is used for accommodating a battery. The battery accommodating module includes a battery case and a latch member. The battery case has an accommodating space and a side of the battery case has two pivot holes and at least one first restraining portion. The latch member has two pivot portions and at least one second restraining portion, wherein the pivot portions are pivotally connected to the pivot holes, such that the latch member can rotate with respect to the battery case between a lock position and an unlock position. When the latch member is located at the unlock position, the first restraining portion keeps the second restraining portion at a first side of the first restraining portion. When the latch member is located at the lock position, the first restraining portion keeps the second restraining portion at a second side of the first restraining portion.