Abstract: Use of a stereoselective transaminase in the asymmetric synthesis of a chiral amine. In particular, provided is use of a polypeptide in the production of a chiral amine or a downstream product using a chiral amine as a precursor. Further provided is a method for producing a chiral amine, comprising culturing a strain expressing the polypeptide so as to obtain a chiral amine. Further provided are novel prochiral compounds, a chiral amine production strain and a method for constructing the chiral amine production strain. The stereoselective transaminase has a broad substrate spectrum and thus has a broad application potential in the preparation of a chiral amine.

Abstract: Provided are a fused tricyclic compound having the structure shown in formula (I), a pharmaceutical composition thereof, and a use thereof. The fused tricyclic compound serves as a selective inhibitor of KRAS mutation, and has high activity, good selectivity. and reduced toxic side effects.

Abstract: Disclosed is a method for producing low carbon olefins and/or aromatics from feedstock comprising naphtha. The method can include the following steps: a) feeding feedstock comprising naphtha into a fast fluidized bed reactor; b) contacting the feedstock with a catalyst under conditions to produce a gas product and spent catalyst; c) separating the gas product to produce a stream comprising primarily one or more low carbon olefins and/or one or more aromatics; d) transporting the spent catalyst to a regenerator; e) regenerating the spent catalyst in the regenerator to form regenerated catalyst; and f) returning the regenerated catalyst to the fast fluidized bed reactor.

Abstract: Provided herein are TiO2-x nanoparticles and materials that show unusual photophysical and optical properties. These TiO2-x particles and materials can be used as efficient photocatalysts for the reduction of CO2 with H2O to produce CH4. Also provided herein are methods of making TiO2-x nanoparticles using a polymer-derived mesoporous carbon (PDMC) as a template.

Abstract: An electronic device manufacturing system capable of obtaining metrology data generated using metrology equipment located within a process chamber that performs a deposition process on a substrate according to a process recipe, wherein the process recipe comprises a plurality of setting parameters, and wherein the deposition process generates a plurality of film layers on a surface of the substrate. The manufacturing system can further generate a correction profile based on the metrology data. The manufacturing system can further generate an updated process recipe by applying the correction profile to the process recipe. The manufacturing system can further cause an etch process to be performed on the substrate according to the updated process recipe.

Abstract: A method includes receiving first sensor data, generated during a manufacturing process by sensors associated with a substrate manufacturing chamber. The method further includes receiving simulated sensor data generated by a trained physics-based model. The method further includes determining which one or more components of the manufacturing chamber contribute to a difference between the first sensor data and the simulated sensor data. The method further includes causing performance of a corrective action in view of the difference.

Abstract: A method may include defining a rule identifying an event that triggers a change in a value of a metric. The defining of the rule includes generating a subscription to receive the event from an event stream. Occurrences of the event identified by the rule may be detected based on receiving the event from the event stream. In response to each occurrence of the event, the value of the metric and/or the change in the value of the metric may be evaluated. A notification may be sent to a software application consuming the metric based on the value of the metric and/or the change in the value of the metric satisfying a threshold. Related systems and computer program products are also provided.

Abstract: Disclosed are an air dispersing device and a floor air conditioner. The air dispersing device includes an air dispersing frame and an air dispersing module. The air dispersing frame includes a first air dispersing plate and a second air dispersing plate, and an air cavity is formed between the first air dispersing plate and the second air dispersing plate. An air dispersing hole is provided on the first air dispersing plate, and a ventilation opening is provided on the second air dispersing plate. The air dispersing module includes a movable impeller, the movable impeller is rotatably provided in the air cavity, and the movable impeller is configured to disperse airflows.

Abstract: A lens unit, a lens for a low-beam illumination module, a low-beam illumination module and a vehicle. The lens unit includes a rear surface and a front surface; the lens unit has a focal line, and the focal line is a straight line perpendicular to a light emitting direction of the lens unit; the rear surface and the front surface are adapted to project light rays passing through the focal line into parallel light rays, and the front surface is a free-form curved surface. The lens unit has the optical characteristics of a cylindrical lens, and is able to cause parallel incident light to be focused into a line instead of a focal point upon passing through the lens unit.

Abstract: A blood pump system including an optical sensor configured to detect an optical signal during pumping operation of the blood pump, and an optical fiber configured to transmit the optical signal from the optical fiber sensor to an evaluation device communicatively coupled to the optical fiber sensor. The evaluation device is configured to receive as inputs the transmitted optical signal and a signal indicative of the motor current and determine a mechanical failure event associated with the blood pump based on the motor current and the optical signal.

Abstract: An ear-wearable electronic device is operable to apply a low-pass filter to the digitized voice signal to remove a high-frequency component and obtain a low-frequency component. Speech enhancement is applied to the low-frequency component. Blind bandwidth extension is applied to the enhanced low-frequency component to recover or synthesize an estimate of at least part of the high frequency component. An enhanced speech signal is output that is a combination of the enhanced low-frequency component and the bandwidth-extended high frequency component.

Abstract: The present disclosure relates to an overflow structure of a kitchen appliance. A motor is assembled in a mainframe of the kitchen appliance. A mainframe upper cover is disposed above the motor, and the mainframe upper cover is connected to the mainframe and is used to place a container cup assembly, a shaft of the motor is connected to a clutch assembly for power transmission, a base is installed at a lower end of the mainframe. The overflow structure includes: a mainframe-upper-cover drainage structure including at least one side drainage hole opened at an edge of the mainframe upper cover, and a first water receiving part for transferring liquid in the side drainage hole; an interference drainage structure including a water receiving tray for receiving liquid overflowing from a gap between the clutch assembly and the mainframe upper cover, and a second water receiving component for transferring liquid in the water receiving tray.

Abstract: An aromatic compound protein inhibitor, a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, a method related to the preparation and use of the compound, a pharmaceutical composition comprising the compound, and a relevant cancer treatment method. The aromatic compound has selective and significant inhibitory activity on a protein, and has a wide application prospect in the field of tumor treatment.

Abstract: The present disclosure provides a high-performance data lake system and a data storage method. The data storage method includes the following steps: S1: converting a file into a file stream; S2: converting the file stream into an array in which multiple subarrays are nested; and S3: converting the array into a resilient distributed dataset (RDD), and storing the RDD to a storage layer of a data lake. The present disclosure provides a nested field structure, which lays the foundation for parallel processing in reading, and effectively improves read performance. Furthermore, the present disclosure flexibly generates a number of nested subarrays according to hardware cores, such that the data lake achieves better extension performance, and can keep optimal writing efficiency for different users.

Abstract: The subject application provides a zero-voltage switching flyback converter comprising: a transformer having a primary winding and a secondary winding; a primary switch and a secondary switch for conducting the currents flowing in the primary winding and secondary winding respectively. A timing control method for operating the flyback converter are provided to accomplish zero-voltage switch by turning on the secondary switch twice within one switching power cycle.

Abstract: A method includes: acquiring a plurality of historical routes of movement of a plurality of historical users in a geographic area, wherein each historical route includes at least a portion of a plurality of locations; determining, based on the plurality of historical routes and a plurality of current positions of a plurality of users in the geographic area, a set of predicted locations among the plurality of locations that the plurality of users will visit in the future, respectively, wherein the plurality of users use a tour guiding service associated with the plurality of locations that is provided by a mobile network; selecting a set of popular locations from the set of predicted locations based on the number of users among the plurality of users who will visit each predicted location in the set of predicted locations; and scheduling tour guiding resources associated with the set of popular locations.

Abstract: A regeneration device, a device for preparing low-carbon olefins, and a use thereof are provided. The regeneration device includes a first regenerator and a second regenerator; a first activation zone of the first regenerator is connected to the second regenerator through a pipeline, such that a catalyst in the first activation zone is able to be delivered to the second regenerator; and the second regenerator is connected to a gas-solid separation zone of the first regenerator through a pipeline, such that a catalyst in the second regenerator is able to be delivered to the gas-solid separation zone. The regeneration device can adjust the coke content, coke content distribution, and coke species in a dimethyl ether/methanol to olefins (DMTO) catalyst to control an operation window of the DMTO catalyst, which improves the selectivity for low-carbon olefins and the atomic economy of a methanol-to-olefins (MTO) technology.

Abstract: The subject application provides a zero-voltage switching flyback converter comprising: a transformer having a primary winding and a secondary winding; a primary switch and a secondary switch for conducting the currents flowing in the primary winding and secondary winding respectively. A timing control method for operating the flyback converter are provided to accomplish zero-voltage switch by turning on the secondary switch twice within one switching power cycle.