Patents by Inventor Tariq Ghayur

Tariq Ghayur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TNF/IL-17 DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF
    Publication number: 20150056202
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: March 25, 2014
    Publication date: February 26, 2015
    Inventors: Chengbin Wu, Tariq Ghayur, Richard W. Dixon, Jochen G. Salfeld
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150017168
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 15, 2015
    Applicant: ABBVIE INC.
    Inventors: Tariq Ghayur, Junjian Liu, Gillian A. Kingsbury, Edward B. Reilly, Susan E. Morgan-Lappe
  • PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20150017095
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Inventors: Tariq Ghayur, Jijie Gu, Peter Isakson
  • Dual Variable Domain Immunoglobulin and Uses Thereof
    Publication number: 20150004167
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: May 29, 2014
    Publication date: January 1, 2015
    Applicant: AbbVie Inc.
    Inventors: Chengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD
  • Dual Variable Domain Immunoglobulin and Uses Thereof
    Publication number: 20140377858
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 25, 2014
    Applicant: AbbVie Inc.
    Inventors: Chengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD
  • Dual Variable Domain Immunoglobulin and Uses Thereof
    Publication number: 20140377805
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: May 29, 2014
    Publication date: December 25, 2014
    Applicant: AbbVie Inc.
    Inventors: Chengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD
  • DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING
    Publication number: 20140378666
    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1? and IL-1? and neutralize IL-1? and IL-1? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1? and IL-1?) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1? and/or IL-1? activity is detrimental.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 25, 2014
    Applicant: ABBVIE INC.
    Inventors: Albert COLLINSON, George Avgerinos, Richard DIXON, Tariq GHAYUR, Zehra KAYMAKCALAN
  • DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17
    Publication number: 20140356281
    Abstract: Engineered multivalent and multispecific binding proteins that bind IL-1? and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 3, 2014
    Publication date: December 4, 2014
    Inventors: Tariq Ghayur, JiJie Gu, Maria Harris, Carrie Goodreau, Sonal Saluja
  • IL-1 ALPHA DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140335014
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 8, 2014
    Publication date: November 13, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq Ghayur, Peter C. Isakson, Lisa M. Olson, Chengbin Wu, Margaret Hugunin, Rajesh V. Kamath, Carolyn A. Cuff, Hamish Allen
  • TNF-? binding proteins
    Patent number: 8877194
    Abstract: TNF-? binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-? are provided. Binding proteins have high affinity for TNF-? and neutralize TNF-? activity. A binding protein can be a full-length antibody or a TNF-?-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-? binding proteins are useful for detecting TNF-? and for inhibiting TNF-? activity, including in a human subject suffering from a disease or disorder in which TNF-? activity is detrimental.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: November 4, 2014
    Assignee: AbbVie Inc.
    Inventors: Chung-ming Hsieh, Carrie L. Goodreau, Sahana Bose, Achim Moeller, Tariq Ghayur
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140308286
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: March 19, 2014
    Publication date: October 16, 2014
    Applicant: AbbVie Inc.
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu
  • Dual variable domain immunnoglobulins and uses thereof
    Patent number: 8853365
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: October 7, 2014
    Assignee: ABBVIE Inc.
    Inventors: Chengbin Wu, Dominic J. Ambrosi, Chung-ming Hsieh, Tariq Ghayur
  • TNF Binding Proteins
    Publication number: 20140294813
    Abstract: Provided are TNF binding proteins and methods of treatment using the same. Also provided are nucleic acids encoding the binding proteins and recombinant expression vectors and host cells for making such binding proteins.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq Ghayur, Dominic Ambrosi, Arun B. Deora, Subramanya Hegde
  • IL-1 binding proteins
    Patent number: 8841417
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: September 23, 2014
    Assignee: ABBVIE Inc.
    Inventors: Chengbin Wu, Dominic J. Ambrosi, Chung-ming Hsieh, Tariq Ghayur
  • DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17
    Publication number: 20140271458
    Abstract: Engineered multivalent and multispecific binding proteins that bind IL-1? and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: AbbVie Inc.
    Inventors: Tariq Ghayur, JiJie Gu, Maria Harris, Carrie Goodreau, Sonal Saluja
  • Dual Specific Binding Proteins Directed Against TNF
    Publication number: 20140271457
    Abstract: Engineered multivalent and multispecific binding proteins that bind TNF? and IL-13, TNF? and PGE2, or TNF? and NGF are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: ABBVIE INC.
    Inventors: Tariq Ghayur, Carrie Goodreau
  • Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
    Patent number: 8822645
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: September 2, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Jijie Gu, Peter C. Isakson
  • METHODS AND COMPOSITIONS FOR MODULATING AN IMMUNE RESPONSE
    Publication number: 20140242077
    Abstract: Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as T-cells (e.g., cytotoxic T-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic T-cells) in a subject (e.g., a human subject). Also provided are nucleic acids, expression vectors and host cells encoding the multispecific binding proteins.
    Type: Application
    Filed: January 23, 2014
    Publication date: August 28, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chee-Ho CHOI, Qingfeng TAO, Philip BARDWELL, Tariq GHAYUR
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140234208
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 21, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140220019
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON