Patents by Inventor Tariq Ghayur

Tariq Ghayur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20110318349
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 29, 2011
    Inventors: Tariq Ghayur, Junjian Liu, James P. Jakway, Robert V. Talanian, Lorenzo Benatuil
  • IL-1 BINDING PROTEINS
    Publication number: 20110280800
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: May 13, 2011
    Publication date: November 17, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Chengbin WU, Tariq GHAYUR, Chung-ming HSIEH, Dominic J. AMBROSI
  • Dual Variable Domain Immunnoglobulins and Uses Thereof
    Publication number: 20110263827
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 30, 2010
    Publication date: October 27, 2011
    Applicant: Abbott Laboratories
    Inventors: Tariq Ghayur, Junjian Liu, Gillian A. Kingsbury, Edward B. Reilly, Susan E. Morgan-lappe
  • TNF-ALPHA BINDING PROTEINS
    Publication number: 20110250130
    Abstract: Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-?), e.g., human TNF-?, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
    Type: Application
    Filed: April 6, 2011
    Publication date: October 13, 2011
    Inventors: Lorenzo Benatuil, Tariq Ghayur, Carrie L. Goodreau, Peter C. Isakson, Jochen Salfeld
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20110212094
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 28, 2010
    Publication date: September 1, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu
  • IL-18 binding proteins
    Patent number: 7968684
    Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: June 28, 2011
    Assignee: Abbott Laboratories
    Inventors: Tariq Ghayur, Boris Labkovsky, Jeffrey W. Voss, Larry Green, John Babcook, Xiao-chi Jia, James Wieler, Jaspal Singh Kang, Brad Hedberg
  • TRANSGENIC ANIMALS EXPRESSING ANTIBODIES SPECIFIC FOR GENES OF INTEREST AND USES THEREOF
    Publication number: 20110154521
    Abstract: The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the product of a gene of interest that has been functionally disrupted in the transgenic animal. Furthermore, the methods and compositions of the invention are suitable for use in the treatment, diagnosis, and imaging of disease.
    Type: Application
    Filed: September 10, 2010
    Publication date: June 23, 2011
    Applicant: ABBOTT LABORATORIES
    Inventor: Tariq Ghayur
  • NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF
    Publication number: 20110142845
    Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
    Type: Application
    Filed: September 13, 2010
    Publication date: June 16, 2011
    Applicant: Abbott Laboratories
    Inventors: Mario Mezler, Achim Moeller, Reinhold Mueller, Bernhard K. Mueller, Tariq Ghayur, Eve Barlow, Martin Schmidt, Axel Meyer, Nicole Teusch
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110091463
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Rajesh V. Kamath, Junian Liu, Marie P. Honore
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110091372
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: September 1, 2010
    Publication date: April 21, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
    Patent number: 7906120
    Abstract: The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: March 15, 2011
    Assignee: Abbott Laboratories
    Inventors: Mario Mezler, Achim Moeller, Reinhold Mueller, Bernhard K. Mueller, Tariq Ghayur, Eve H. Barlow, Martin Schmidt, Axel Meyer, Nicole E. Teusch
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110044980
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 29, 2010
    Publication date: February 24, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Alexander Ibraghimov
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20110008766
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 30, 2010
    Publication date: January 13, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Junjian Liu, Susan E. Brophy, Sushil G. Devare, Frank C. Grenier, Jeffrey A. Moore, Qiaoqiao Ruan, Sergey Y. Tetin, Jennifer M. Steinhaus, Salman Ali, Hina N. Syed
  • IL-18 BINDING PROTEINS
    Publication number: 20100291088
    Abstract: The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 18, 2010
    Applicant: Abbott Laboratories
    Inventors: Tariq Ghayur, Boris Labkovsky, Jeffrey W. Voss, Larry Green, John Babcook, Xiao-chi Jia, James Wieler, Jaspal Singh Kang, Brad Hedberg
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20100260668
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 14, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Susan E. Morgan-lappe, Edward B. Reilly, Gillian A. Kingsbury, Andrew Phillips, Jieyi Wang, Randy L. Bell, Suzanne M. Norvell, Yingchun Li, Junjian Liu, Hua Ying, Zhihong Liu
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20100233079
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 4, 2009
    Publication date: September 16, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Clarissa G. Jakob, Chengbin Wu, Karl A. Walter, Tariq Ghayur
  • Transgenic mice expressing antibodies specific for genes of interest and uses thereof
    Patent number: 7795494
    Abstract: The invention provides compositions and methods for the generation of novel non-human transgenic animals which contain an alteration in a gene of interest. These transgenic animals are capable of generating antibodies, e.g., human monoclonal antibodies, specific for the product of a gene of interest that has been functionally disrupted in the transgenic animal. Furthermore, the methods and compositions of the invention are suitable for use in the treatment, diagnosis, and imaging of disease.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 14, 2010
    Assignee: Abbott Laboratories
    Inventor: Tariq Ghayur
  • METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION
    Publication number: 20100087436
    Abstract: Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed.
    Type: Application
    Filed: May 12, 2009
    Publication date: April 8, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Philip Bardwell, Tariq Ghayur, Jijie Gu, Ingela Beatrice Vikstrom, Andrew Mark Lew, David Matthew Tarlinton, Emma Margarele Carrington, David Ching Siang Huang
  • PROSTAGLANDIN E2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20100074900
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: July 8, 2009
    Publication date: March 25, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Jije Gu, Peter C. Isaakson
  • Dual Variable Domain Immumoglobulins and Uses Thereof
    Publication number: 20100076178
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: April 28, 2009
    Publication date: March 25, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Tariq Ghayur, Susan E. Morgan-Lappe, Edward B. Reilly, Gillian A. Kingsbury, Andrew Phillips, Jieyi Wang, Randy L. Bell, Suzanne M. Norvell, Yingchun Li, Junjian Liu, Hua Ying