Patents by Inventor Tariq Ghayur

Tariq Ghayur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dual Specific Binding Proteins Having a Receptor Sequence
    Publication number: 20140219913
    Abstract: Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 27, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq Ghayur, Philip Bardwell
  • IL-1 BINDING PROTEINS
    Publication number: 20140220020
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 26, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • MONOVALENT BINDING PROTEINS
    Publication number: 20140221622
    Abstract: Engineered monovalent binding proteins that bind to one or more ligands (such as an antigen) via one binding domain are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 27, 2013
    Publication date: August 7, 2014
    Applicant: ABBVIE, INC.
    Inventors: Tariq GHAYUR, Jijie GU
  • DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    Publication number: 20140219912
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Application
    Filed: December 19, 2013
    Publication date: August 7, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Junjian LIU, Peter C. ISAKSON
  • IL-1 BINDING PROTEINS
    Publication number: 20140212925
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 17, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • CROSS-OVER DUAL VARIABLE DOMAIN IMMUNOGLOBULIN CONSTRUCTS
    Publication number: 20140213772
    Abstract: Engineered cross-over DVD-Ig binding proteins that bind to two or more target proteins (e.g., antigens) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Jijie GU
  • Dual Variable Domain Immunoglobulin and Uses Thereof
    Publication number: 20140213768
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: September 10, 2013
    Publication date: July 31, 2014
    Applicant: ABBVIE INC.
    Inventors: Chengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD
  • MULTI-SPECIFIC BINDING PROTEINS
    Publication number: 20140213771
    Abstract: Engineered multi-specific binding proteins that bind to one or more target proteins (e.g., antigens) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 27, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie, Inc.
    Inventors: Tariq GHAYUR, Dominic J. AMBROSI
  • IL-1 BINDING PROTEINS
    Publication number: 20140212379
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 16, 2013
    Publication date: July 31, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • BLOOD-BRAIN BARRIER PENETRATING DUAL SPECIFIC BINDING PROTEINS
    Publication number: 20140212423
    Abstract: Engineered multivalent and multispecific binding proteins capable of penetrating the blood-brain barrier (BBB) are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: December 4, 2013
    Publication date: July 31, 2014
    Applicant: ABBVIE, INC.
    Inventors: Denise KARAOGLU HANZATIAN, Tariq GHAYUR, Annette J. SCHWARTZ STERMAN, Andrew GOODEARL, Maria Cristina HARRIS
  • IL-1 BINDING PROTEINS
    Publication number: 20140205562
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 24, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin WU, Dominic J. Ambrosi, Chung-ming Hsieh, Tariq Ghayur
  • PROSTAGLANDIN E2 BINDING PROTEINS AND USES THEREOF
    Publication number: 20140186377
    Abstract: The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.
    Type: Application
    Filed: November 26, 2013
    Publication date: July 3, 2014
    Applicant: AbbVie, Inc.
    Inventors: Jijie Gu, Charles W. Hutchins, Rong-Rong Zhu, Jianwei Shen, Maria C. Harris, Eileen Belanger, Tariq Ghayur, Paul R. Hinton, Veronica M. Juan, John Mankovich, Junjian Liu
  • DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING
    Publication number: 20140155579
    Abstract: Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1? and IL-1? and neutralize IL-1? and IL-1? activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1? and IL-?) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1? and/or IL-1? activity is detrimental.
    Type: Application
    Filed: May 23, 2013
    Publication date: June 5, 2014
    Applicant: AbbVie Inc.
    Inventors: Albert Collinson, George Avgerinos, Richard Dixon, Tariq Ghayur, Zehra Kaymakcalan
  • ANTI-IL1ALPHA/BETA DUAL VARIABLE DOMAIN IMMUNOGLOBULIN AND USES THEREOF
    Publication number: 20140154256
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 5, 2014
    Applicant: AbbVie, Inc.
    Inventors: Chengbin Wu, Tariq Ghayur, Richard W. Dixon, Jochen G. Salfeld
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8735546
    Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: May 27, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Junjian Liu, Peter C. Isakson
  • Dual Variable Domain Immunoglobulins and Uses Thereof
    Publication number: 20140134171
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Application
    Filed: October 17, 2013
    Publication date: May 15, 2014
    Applicant: ABBVIE INC.
    Inventors: Tariq Ghayur, Junjian Liu, Sharmila Manoj, Susan E. Brophy
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8722855
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: May 13, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Jochen G. Salfeld, Michael J. McPherson, Maria C. Harris, Junjian Liu, Peter C. Isakson, Jijie Gu
  • Dual variable domain immunoglobulins and uses thereof
    Patent number: 8716450
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 6, 2014
    Assignee: AbbVie Inc.
    Inventors: Tariq Ghayur, Rajesh V. Kamath, Junian Liu, Marie P. Honore
  • IL-1 BINDING PROTEINS
    Publication number: 20140099671
    Abstract: Proteins that bind IL-1? and IL-1? are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1? and IL-1? in cells, tissues, samples, and compositions.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 10, 2014
    Applicant: ABBVIE, INC.
    Inventors: Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
  • Dual Variable Domain Immunoglobulin and Uses Thereof
    Publication number: 20140100359
    Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
    Type: Application
    Filed: September 10, 2013
    Publication date: April 10, 2014
    Applicant: ABBVIE INC.
    Inventors: Chengbin WU, Tariq GHAYUR, Richard W. DIXON, Jochen G. SALFELD