Patents by Inventor Tariq Ghayur

Tariq Ghayur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified interleukin-1&bgr; converting enzyme with increased stability
    Patent number: 6242240
    Abstract: Modified forms of human interleukin-1&bgr; converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic acid molecules encoding a modified p10 subunit of ICE, and recombinant vectors and host cells incorporating such nucleic acid molecules, are also disclosed. A modified ICE protein of the invention can be used to cleave proteolytically ICE substrates and to identify modulators of ICE activity in screening assays. Moreover, due to its enhanced stability, the modified ICE of the invention is particularly suitable for use in the preparation of ICE crystals for X-ray crystallography.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: June 5, 2001
    Assignee: BASF Aktiengellschaft
    Inventors: Robert V. Talanian, John A. Mankovich, Tariq Ghayur, Catherine R. Ferenz
  • Methods and cell lines for screening compositions and genes for ability to interact with IL-1&bgr; and ice processing
    Patent number: 6187550
    Abstract: Embodiments of the present invention are directed to non-naturally occurring cells and methods for screening compositions and genes which interact with interleukin 1 beta and interleukin-1 beta converting enzyme (ICE) processing, methods and non-naturally occurring cells for making ICE, and agonists and inhibitors of ICE.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: February 13, 2001
    Assignee: BASF AG
    Inventors: Tariq Ghayur, Lorraine M. McGuinness
  • Methods and compositions for modulating responsiveness to corticosteroids
    Patent number: 6054487
    Abstract: Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a factor that regulates production of IFN-.gamma. in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an interferon-.gamma. inducing factor (IGIF) antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists. The methods of the invention can be used in the treatment of a variety of inflammatory and immunological diseases and disorders.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: April 25, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Les Sekut, Adam Carter, Tariq Ghayur, Subhashis Banerjee, Daniel E. Tracey
  • Modified interleukin-1.beta. converting enzyme with increased stability
    Patent number: 5869315
    Abstract: Modified forms of human interleukin-1.beta. converting enzyme (ICE) that display proteolytic activity and, furthermore, have increased stability compared to unmodified human ICE are disclosed. Nucleic acid molecules encoding a modified p10 subunit of ICE, and recombinant vectors and host cells incorporating such nucleic acid molecules, are also disclosed. A modified ICE protein of the invention can be used to cleave proteolytically ICE substrates and to identify modulators of ICE activity in screening assays. Moreover, due to its enhanced stability, the modified ICE of the invention is particularly suitable for use in the preparation of ICE crystals for X-ray crystallography.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: February 9, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Robert V. Talanian, John A. Mankovich, Tariq Ghayur, Catherine R. Ferenz
  • Ice and ice-like compositions and methods of making same
    Patent number: 5492824
    Abstract: The present invention is directed to ICE and ICE-like compositions formed by combining two subunits of ICE and folding such subunits to form an active enzyme.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 20, 1996
    Assignee: BASF AG
    Inventors: Robert V. Talanian, Leonard L. C. Dang, Nigel P. C. Walker, Tariq Ghayur