Abstract: Described herein are processes and enzymes for the enzymatic production of glucaric acid from glucuronic acid, and more specifically the enzymatic production of substituted glucaric acid from substituted glucuronic acid. Advantageously, the process and enzymes described herein make preferential use substituted glucuronic acid obtained from natural sources, such as underutilized hemicellulose stream from wood and agricultural biorefineries, to produce substantially enantiomerically pure substituted D-glucaric acid.

Abstract: A polyvinyl chloride (PVC) composition and a method for preparing a polymer composite article. The composition comprises (A) a mineral filler in an amount of from 7.5 to 75 wt. %. The composition also comprises (B) a polyvinyl chloride polymer in an amount of from 20 to 92 wt. %. Further, the composition comprises (C) a polydiorganosiloxane in an amount of from greater than 0 to 5 wt. %; the (C) polydiorganosiloxane being a compound of unit formula: (R2R?SiO1/2)a(R3SiO1/2)b(R2SiO2/2)c(RR?SiO2/2)d, where each R is an independently selected monovalent hydrocarbon group of 1 to 18 carbon atoms that is free of aliphatic unsaturation, each R? is an independently selected alkenyl group of 2 to 18 carbon atoms, subscript a is 0 to 2, subscript b is 0 to 2, a quantity (a+b)=2, subscript c?0, subscript d?0, a quantity (a+d)?1, and a quantity (a+b+c+d) is sufficient to give the polydiorganosiloxane a viscosity of 2,000 mPa·s to 60,000 mPa·s at 25° C. measured at 0.

Abstract: A polyvinyl chloride (PVC) composition and a method for preparing a polymer composite article. The composition comprises (A) a mineral filler in an amount of from 7.5 to 75 wt. %. The composition also comprises (B) a polyvinyl chloride polymer in an amount of from 20 to 92 wt. %. Further, the composition comprises (C) a polydiorganosiloxane in an amount of from greater than 0 to 5 wt. %; the (C) polydiorganosiloxane being a compound of formula (I): where each R is an independently selected monovalent hydrocarbon group of 1 to 18 carbon atoms that is free of aliphatic unsaturation, and subscript x has a value sufficient to give the (C) polydiorganosiloxane a viscosity of greater than 350 mPa·s to 100,000 mPa·s measured at 25° C. at 0.1 RPM to 50 RPM on a Brookfield DV-III cone & plate viscometer with #CP-52 spindle. The ranges for components (A)-(C) are based on the total weight of components (A), (B) and (C) in the composition.

Abstract: The present invention is a composition comprising a blend of a PVA based latex and an EA/MMA based polyacrylic latex. The composition of the present invention is useful in a paint formulation for providing a coating with superior scrub resistance over a formulation comprising a blend of a PVA based latex and a BA/MMA based polyacrylic latex.

Abstract: A prosthesis for replacing a natural articular surface on a bone may have a joint facing side with an articular surface, a bone anchoring side with a bone engagement surface, and a bone engagement pad secured to at least part of the bone engagement surface. The bone engagement pad may have a transverse portion extending transverse to a length of the bone, and one or more protruding portions extending generally perpendicular to the transverse portion. The transverse portion may have a pad bone-facing surface with a first porosity level, and a pad joint-facing surface on an opposite side of the transverse portion from the pad bone-facing surface, with a second, lower porosity level. The bone engagement surface may be formed via a first manufacturing process selected from the group consisting of forging, milling, and casting. The bone engagement pad may be formed via an additive manufacturing process.

Abstract: The present specification discloses an entertainment/educational system having one or more interactive stations having associated systems comprising apparatus and activities that demonstrate various physical phenomenon. Each interactive station comprises a different system featuring differing apparatus that provides users the ability to form various types and numbers of bubbles that the users can experience and interact with. User progression and interaction with a particular set of/order of interactive stations is correlated with lessons about physical phenomena exemplified by the bubbles made at a particular station of the total stations visited. The lessons may be further enhanced by information provided to users via a poster, handout, booklet or other informative media or information provided by a guide/attendant escorting user(s) through the set of stations.

Abstract: Systems and associated methods are described for providing recording of a blacked out media content item. A system receives a request from a first user device associated with a profile to record a media content item scheduled to broadcast on a second user device (different from the first user device) associated with the profile, at a second location. The system determines that the media content item is subject to a blackout during a blackout period within a blackout region. The system determines that the first user device and the second user device are associated with the same profile and that the first user device is at a first location outside the blackout region. The system then accesses the media content item for recording on the second user device during the blackout period. The system further transmits the recorded media content item to the first user device after expiry of the blackout period.

Abstract: Disclosed herein are methods for promoting healthy neural development in an unborn baby, which include administering to a maternal subject gestating the unborn baby a composition or a bacterial composition. Compositions can include trimethylamine N-oxide (TMAO), 5-aminovalerate (5-AV), imidazole propionate (IP), hippurate (HIP), or a combination thereof, and the bacterial compositions can include bacteria of the order Clostridiales. Also disclosed are methods for conditioning a female subject for bringing about offspring with healthy neural development. Additionally disclosed are methods for reducing adverse effects of antibiotic treatment on an unborn baby in a pregnant subject. Also disclosed are methods for selecting a female subject for conditioning to foster healthy neural development in offspring.

Abstract: A formula and the process of manufacturing of a cannabinoid compound are disclosed which comprise: a cannabidiol element (CBD) having a first predetermine percentage (%) by weight; a ?9 tetrahydrocannabinol (THC) element having a second predetermine percentage (%) by weight (w/w); and saturated fatty acids having a third predetermined percentage (%) of weight (w/w); wherein the saturated fatty acids improve anti-oxidation and heat resistance to the cannabinoid compound.

Abstract: A method of detecting bots, preferably in an operating environment supported by a content delivery network (CDN) that comprises a shared infrastructure of distributed edge servers from which CDN customer content is delivered to requesting end users (clients). The method begins as clients interact with the edge servers. As such interactions occur, transaction data is collected. The transaction data is mined against a set of “primitive” or “compound” features sets to generate a database of information. In particular, preferably the database comprises one or more data structures, wherein a given data structure associates a feature value with its relative percentage occurrence across the collected transaction data. Thereafter, and upon receipt of a new transaction request, primitive or compound feature set data derived from the new transaction request are compared against the database. Based on the comparison, an end user client associated with the new transaction request is then characterized, e.g.

Abstract: A display apparatus, and a method for the display apparatus. The display apparatus includes a main frame, a magnet movably positioned on the main frame, and a light emitting diode (LED) module assembly detachably positioned on the main frame. The LED module assembly includes a plurality of LED modules, and a support frame on which the plurality of LED modules are installed, the support frame comprising a magnetic material interacting with the magnet. The display apparatus further includes a power cable configured to supply power to the plurality of LED modules, and a cover installed in the main frame to facilitate a connection of the power cable.

Abstract: The present invention relates to a housing of an electric machine (1), comprising a hollow cylindrical housing element (5), in particular housing jacket, and at least one housing cover (6), which is attached to the end of the housing element (5), a cooling channel (8) being formed in the housing, the housing element (5) having at least two cooling channel sections (8.1) of the cooling channel (8), which each extend from a channel end opening (13) in an end face (11) of the housing element (5) in an axial direction relative to a housing axis (100) into the housing element (5). Two adjacent cooling channel sections (8.1) are flow-connected to each other via a deflection section (8.2) formed in the housing cover (6).

Abstract: A camera with a field of view of a shelf may acquire images of items on the shelf at subsequent times. An analysis of each image yields a set of estimated locations of the items on the shelf. Based on a working volume of the shelf, a subset of valid estimated locations of the items at the shelf may be determined. Thereafter, a count of the items on the shelf at a particular time may be determined using the subset of valid estimated item locations. By comparing the count of items at the shelf at two subsequent times, a change in quantity of the items on the shelf may be determined. Interaction data may be generated in response to detecting the change in quantity of items at the shelf.

Abstract: A server interacts with a bot detection service to provide bot detection as a requesting client interacts with the server. In an asynchronous mode, the server injects into a page a data collection script configured to record interactions at the requesting client, to collect sensor data about the interactions, and to send the collected sensor data to the server. After the client receives the page, the sensor data is collected and forwarded to the server through a series of posts. The server forwards the posts to the detection service. During this data collection, the server also may receive a request from the client for a protected endpoint. When this occurs, and in a synchronous mode, the server issues a query to the detection service to obtain a threat score based in part on the collected sensor data that has been received and forwarded by the server. Based on the threat score returned, the server then determines whether the request for the endpoint should be forwarded onward for handling.

Abstract: Provided herein are methods and compositions related to treating or preventing seizures. In some aspects, provided herein are methods of treating or preventing seizures in a subject by administering to the subject a composition comprising Parabacteroides and Akkermansia bacteria.

Abstract: The present invention provides immunostimulatory nucleic acids that have an affinity to a specific target protein. The present invention also provides templates and methods for making and using the immunostimulatory nucleic acids. Further, methods for linking the immunostimulatory nucleic acids to antigens and using the resulting complexes to enhance an immune response are provided.

Abstract: Systems and associated methods are described for providing recording of a blacked out media content item. A system receives a request from a first user device associated with a profile to record a media content item scheduled to broadcast on a second user device (different from the first user device) associated with the profile, at a second location. The system determines that the media content item is subject to a blackout during a blackout period within a blackout region. The system determines that the first user device and the second user device are associated with the same profile and that the first user device is at a first location outside the blackout region. The system then accesses the media content item for recording on the second user device during the blackout period. The system further transmits the recorded media content item to the first user device after expiry of the blackout period.

Abstract: A display apparatus includes a frame; a display module including at least one substrate on which a plurality of light emitting elements is mounted, and a bracket to which the at least one substrate is attached; and a magnetic coupling device including a holder fastened to the frame and configured to support the display module, and a magnet received in the holder and configured to apply a magnetic attraction force to pull the display module, wherein the holder may include an adjustment device configured to adjust a position of the display module with respect to the frame while the display module is supported by the frame.

Abstract: A smart shoe, smart shoe system, and a method of a smart shoe are disclosed. A smart shoe system may be used for monitoring patient activity. The smart shoe system may include a shoe having a plurality of pneumatic pressure sensors. The pressure sensors may be configured to detect pressure at a plurality of points in the sole of the shoe. The smart shoe may also include a microprocessor coupled to the pressure sensors and a GPS integrated circuit. The GPS integrated circuit may be used for correlating position of the smart shoe system to activity data generated by the plurality of pressure sensors. Additionally, the smart shoe system may include a flash memory storage for storing data generated by the microprocessor and pressure sensors.

Abstract: Systems and methods for generating a notification for display on a device based on consumption history of a content item are disclosed herein. Control circuitry receives a request to store a content item of a series of sequentially ordered content items. The control circuitry determines whether the request is a new request for a user. Upon determining that the request is the new request, the control circuitry stores a predetermined number of content items of the series of sequentially ordered content items in a storage device. If a threshold amount of the predetermined number of content items has not been displayed on a device, then the control circuitry causes the notification to be displayed on the device.