Abstract: According to one aspect of the invention, a method for manufacturing a hot gas path component of a turbine is provided, the method including forming cooling channels in a surface of a member. The method also includes disposing a layer on the surface of the member to enclose the cooling channels, the layer being disposed on a portion of the member to be cooled and bonding the layer to the surface, wherein bonding comprises heating the member and the layer.

Abstract: One embodiment of a device includes a network filter configured to filter a plurality of network streams in real-time at the network analysis device to access at least one of the plurality of network streams based on filter parameters input to the network filter. The device further includes a processor configured to compile network information associated with the accessed at least one of the plurality of network streams to allow interaction with the network information.

Abstract: The level of security associated with mobile communication device access is advantageously reduced while the mobile device resides at a location deemed to be “safe.” Determining whether the mobile communications device resides at a safe location depends on (a) location coordinates, and (b) frequency and duration of use of the mobile communication device at the location.

Abstract: A method and system for providing personalized message delivery to a user is disclosed. In accordance with the method and system, data specific to a user is gathered, analyzed and used to determine preferences and order of precedence of the user; and personalized message delivery is provided based upon the user's preferences and order of precedence.

Abstract: In an embodiment, a method of binding a human machine interface to an expression of existing computer code may include analyzing the existing computer code to identify one or more bindable expressions in the existing computer code, and receiving a command to bind a human machine interface with one or more of the identified bindable expressions. The method may further include binding, using a processor, one or more of the bindable expressions with the human machine interface in response to the command. The binding may enable the human machine interface to communicate information within the existing computer code in place of the one or more bound expressions. The bound machine interface may communicate information within the computer code while the computer code is executing.

Abstract: A grinding machine wherein coarse and fine grind wheels are mounted to a single rotating spindle. A multiple grind wheel mount is attached to the lower portion of the rotating spindle, the coarse and fine wheels being supported by the wheel mount, the wheel mount containing the mechanism for moving the inner coarse wheel down relative to the stationary outer fine wheel.

Abstract: The present embodiment provides for methods and systems for use in processing objects such as wafers, including polishing and/or grinding wafers. Some embodiments provide systems that include a front-end module and a processing module. The front end module couples with a storage device that stores objects for processing. The front-end module can comprise a single robot, a transfer station, and a plurality of end effectors. The processing module is coupled with the front-end module such that the single robot delivers objects from the storage device to the processing module. The processing module comprising a rotating table, and a spindle with a carrier configured to retrieve the delivered object and process the object on the rotating table.

Abstract: Method and apparatus for securing the transmission of DTMF signals by a telephone over a telephone line. If the telephone is operating in a mode wherein another party may hear any DTMF tone generated by the telephone, such as over the loudspeaker of a speakerphone or as part of a conference call, the telephone prevents generation of an audible signal which predictably corresponds to the actual DTMF value of any button pushed by the user.

Abstract: A grinding machine wherein coarse and fine grind wheels are mounted to a single rotating spindle. A multiple grind wheel mount is attached to the lower portion of the rotating spindle, the coarse and fine wheels being supported by the wheel mount, the wheel mount containing the mechanism for moving the inner coarse wheel down relative to the stationary outer fine wheel.

Abstract: The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

Abstract: A vascular graft includes a proximal section, integral with two branches which terminate in a distal end-to-end section. The end-to-end section is attached to a host artery at end-to-end anastomoses. Flow of blood from the proximal section to the host artery occurs with a self-correcting flow pattern at the opposing junctions, avoiding arterial bed impingement and associated risk of restenosis.

Abstract: Systems and methods are disclosed for surveillance including surveillance units which, in certain aspects, include a first unit for surveillance at a site, the first unit having a first base, a first local archiver, first surveillance apparatus on the base including at least one first surveillance component, the at least one first surveillance component for producing first surveillance signals, first transmitting apparatus for transmitting the first surveillance signals from the first surveillance component to the first local archiver, the local archiver including processing apparatus for processing the first surveillance signals to produce a first record of the surveilling of the site, and the local archiver including connection apparatus for making the first record available by remote access.

Abstract: A device which provides a smoke meter and locator.

Abstract: The present embodiments provide methods, systems and apparatuses for use in grinding work pieces, such as wafers. Some embodiments provide methods that position a grind spindle to contact a first grinding spindle to a face of a work piece, remove a portion of the face, and control the removing of the portion of the face according to a control algorithm. This control algorithm can comprise determining a force applied to the work piece during the removing of the portion of the face, adjusting a feed rate of the first grind spindle when the force applied to the work piece has a predefined relationship with a first threshold level; and dressing a portion of the first grinding portion when the force applied to the work piece has a predefined relationship with a second threshold level that is greater than the first threshold.

Abstract: Method and apparatus for securing the transmission of DTMF signals by a telephone over a telephone line. If the telephone is operating in a mode wherein another party may hear any DTMF tone generated by the telephone, such as over the loudspeaker of a speakerphone or as part of a conference call, the telephone prevents generation of an audible signal which predictably corresponds to the actual DTMF value of any button pushed by the user.

Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) multido system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.

Abstract: The present embodiments provide methods, systems and apparatuses for use in grinding work pieces, such as wafers. Some embodiments provide methods that position a grind spindle to contact a first grinding spindle to a face of a work piece, remove a portion of the face, and control the removing of the portion of the face according to a control algorithm. This control algorithm can comprise determining a force applied to the work piece during the removing of the portion of the face, adjusting a feed rate of the first grind spindle when the force applied to the work piece has a predefined relationship with a first threshold level; and dressing a portion of the first grinding portion when the force applied to the work piece has a predefined relationship with a second threshold level that is greater than the first threshold.

Abstract: A pivoting wafer carrier having a minimum of internal friction and a smooth, continuous pivoting motion. The pivot mechanism includes a lower ring mounted on a pressure plate, an upper ring mounted on a housing upper plate and ball transfer units disposed on the lower ring. Corresponding bearing wedges depend downwardly from the upper ring. As the pressure plate tilts during the polishing process, the load balls of the ball transfer units roll against the corresponding wedges, thus producing a smooth, continuous pivoting motion. A universal joint may be provided to the carrier to effect the rotation of the carrier and to aid the smooth, continuous pivoting motion of the wafer carrier.

Abstract: Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

Abstract: The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.