Abstract: The present disclosure relates to fluoride ion batteries and structures of metal based electrode materials for various fluoride ion batteries. The structures of the metal based electrode materials comprise one or more shells or interfaces, enabling the electrodes to operate at room temperature with a liquid electrolyte.

Abstract: A high-altitude balloon payload with a frame, a GPS and compass module, a flight controller, a sensor probe, an orientation control system and an antenna. The frame is configured to be suspended from a high-altitude balloon. The GPS and compass module is mounted on the frame and is configured to collect location data and orientation data of the frame. The flight controller is mounted on the frame and is configured to control the orientation of the frame based on the location data and the orientation data. The orientation control system is mounted on the frame, operatively coupled to the flight controller, and configured to provide control of the orientation of the frame. The sensor probe is positioned on the frame and configured to take atmospheric measurements. The antenna is configured to establish a radio telemetry link with a ground station and wirelessly communicate the atmospheric measurements to the ground station.

Abstract: An exercise device includes a resistance unit having a connecting gear. It further includes a cable. It further includes an arm that routes the cable to an actuator. The arm is rotatable relative to the resistance unit about the connecting gear, the arm having a central axis. The arm includes a control that mechanically disengages a locking mechanism from the connecting gear. The control is activated by an activation force substantially directed either toward the central axis of the arm, along a length of the arm, or about the central axis. The activation force is mechanically converted into linear force along the arm that disengages the locking mechanism from the connecting gear.

Abstract: Disclosed is a drug delivery device including a housing extending along a longitudinal axis of the drug delivery device, and a distal device portion. The distal device portion includes a distal portion, a proximal portion and at least one intermediate portion. The distal portion includes a distal opening allowing passage of a needle and a bearing surface. The intermediate portion includes at least one wall portion extending proximally from the distal portion to the proximal portion. In at least one state of the drug delivery device, a first radial outer extension of the distal portion in a region axially adjoining the bearing surface is smaller than a second radial outer extension in the intermediate portion, and an outer face of the intermediate portion is inclined relative to the longitudinal axis in a cross section along the longitudinal axis.

Abstract: A drug delivery device with an adjustable injection depth comprises a housing, a support element, and a container retaining space for receiving a container comprising a drug. The support element supports the container within the housing, and the drug delivery device comprises a spacer element. In a first state of the drug delivery device, a first axial position of the container relative to the housing is adjusted by the spacer element being in a first spacer position, and in a second state of the drug delivery device, a second axial position of the container is adjusted by the spacer element being in a second position within the housing or being outside of the housing. The first axial position enables a smaller injection depth of a needle coupled to the container compared to the injection depth enabled if the container is in the second axial position.

Abstract: Various embodiments disclosed relate to an abrasive sheet. The abrasive sheet includes a first layer including an abrasive major surface and an opposite second layer defining a second major surface. The second major surface includes a plurality of protrusions extending outwardly from the second major surface. The protrusions include a first polymer component having at least one of a Shore A hardness ranging from about 5 to about 100 and a Shore D hardness ranging from about 1 to about 70. The first layer and the second layer are directly joined to each other.

Abstract: A drug delivery arrangement (1) comprising a drug delivery device (2), having a housing (3), and a needle, and a tissue receiving element (6), having a needle passage opening (7) and a tissue receiving portion (8), wherein the tissue receiving element is configured to interact with the skin (9) in order to lift tissue into the tissue receiving portion to reduce the risk of injury due to deep punctures.

Abstract: The present disclosure concerns an assembly for an injection device, e.g. an auto-injector device, comprising: a medicament container comprising a medicament container body and a needle protruding from a distal end of the medicament container body and fluidly connected to an interior of the medicament container body, a housing comprising a first bearing surface configured to support the medicament container in a distal direction, a distancing element arranged on the needle and providing a second bearing surface configured to contact a patient's skin during use of the injection device, thereby preventing insertion of the needle into the patient's body beyond a predetermined injection depth.

Abstract: A drug delivery arrangement includes a drug delivery device with a housing adapted to receive a needle that is configured to pierce a skin of a user. The drug delivery device comprises a drive energy source, and is configured to perform a drug delivery operation using the energy obtainable from the drive energy source. The drug delivery device is an autoinjector. An injection depth adjusting member is connectable to or connected to a device member of the drug delivery device. The injection depth adjusting member is configured to provide an adjuster bearing surface with which the drug delivery arrangement bears on the skin during use when the injection depth adjusting member is connected to the device member. When connected to the device member, the injection depth adjusting member is configured to define the injection depth by which the needle can penetrate the skin.

Abstract: An assembly for an injection device, such as an auto-injector device, includes a housing comprising a first bearing surface to support a medicament container in a distal direction, and a needle cover comprising a second bearing surface to protrude from the housing further than a needle of the medicament container at least in a first state and in a first position. The needle cover is arranged in the housing to move telescopically in the housing when a force is exerted upon it in a proximal direction, and the needle cover comprises an opening for the needle to pass through when the needle cover is moved into the housing to a second position. The assembly also includes a coupling element to cause the medicament container to move into the proximal direction in parallel with the needle cover when the needle cover is moved into the proximal direction past the second position.

Abstract: A system to estimate consequences of an explosion includes a scenario generator to generate a scenario based on user input and scenario parameters; an explosive device model generator to generate an explosive device model based on the user input and explosive device parameters; a propagation of hazards modeler to model propagation of hazards into the scenario based on the user input and hazard parameters; an injury modeler to model injuries corresponding to modeling propagation of hazards into the scenario based on injury parameters; and an iteration and output generator to iterate by using additional iterative subsets of the parameters to generate the scenario, generate the explosive device model, model propagation of hazards, and model injuries, until parameter spaces of the parameters are covered. The iteration and output generator generates an injury record based injury outcomes from the modeling of injuries corresponding to the iterating.

Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; a manifold assembly including a rigid manifold having first and second chambers, the rigid manifold configured and arranged to be abutted against the actuation surface for operation, a peristaltic pump tube extending from the first chamber to the second chamber of the rigid manifold, a dialysis fluid container line extending from the first chamber, and a branch line extending between the dialysis fluid container line and the second chamber; and a control unit configured to cause the peristaltic pump actuator to actuate the peristaltic pump tube to pump dialysis fluid from the branch line into the second chamber and from the second chamber into the first chamber.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: A system and method for building and assembling parts of or entire modular structures such as dwelling units, marine structures or watercraft from recycled PET material panels. Each assembly is made from panels of recycled PET material having a core and a rigid skin on both faces of the panel. The panels are joined together with splines of the same type of panel material. The splines may be glued and or fastened in place. The panels provide the necessary rigidity and insulative qualities for construction and watercraft manufacture and may be painted. The panels are impervious to environmental elements as well as to insects.

Abstract: A glass-based assembly includes a glass substrate and a coating layer coupled to the glass substrate. Ultimate strength of the glass substrate with the coating layer overlaying and coupled thereto is greater than that of the glass substrate alone, without the coating layer.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A device for removing material from a vasculature includes a rotation subassembly having a first central axis and a first gear, a valve subassembly having the first central axis and being adjacent to the rotation subassembly, and an actuation system having a second central axis and a second gear. The rotation subassembly is coupled to a catheter to rotate the catheter. The valve subassembly is configured to selectively allow flow of the material from the catheter to the device. The actuation system configured to actuate rotation of the rotation subassembly. The first central axis and the second central axis are parallel.

Abstract: In various embodiments, a gradient modeling application automatically generates designs of three-dimensional (3D) objects. The gradient modeling application generates a set of points based on a resolution and a perimeter. The gradient modeling application computes a set of displacement values based on the set of points, a first two-dimensional (2D) border, and a first displacement parameter that is associated with the first 2D border. Based on the set of displacement values, the gradient modeling application generates a 3D object design.

Abstract: New material compositions, designs and configurations for components for an apparatus that produces a neutron flux such as a nuclear fusion reactor, and methods of manufacturing said new components.

Abstract: Systems, methods, and computer-program products for a dynamic detection threshold for a sensor of an autonomous vehicle are disclosed. A system may include a LIDAR system of an autonomous vehicle. The LiDAR system may include at least one light emitter and at least one light detector to generate analog output signals based on reflected pulses of light. A comparator may receive the analog output signals from the light detector and generate digital output signals based on the analog output signals and a threshold. A controller may receive a first digital output signal of the digital output signals from the comparator based on the threshold, adjust the threshold, receive at least one further digital output signal of the digital output signals from the comparator based on the threshold as adjusted, and/or determine at least one aggregation based on the first digital output signal and the further digital output signal(s).