Abstract: Neutron shielding comprising a metal-hydride metal composite: the metal-hydride metal composite comprising: a metal matrix; and a plurality of metal-hydride particles dispersed within the metal matrix; wherein, the fraction of metal-hydride in the metal-hydride metal composite is at least 1 mol % and the volume fraction of metal-hydride in the metal hydride metal composite is no higher than the ratio of the solid solubility limit of hydrogen in the metal matrix and the molar fraction of hydrogen in the metal-hydride.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: A system for mounting a forklift to a vehicle having a frame. The system includes a core assembly to receive and hold securely a pair of forks of a forklift, a plurality of flange shims to adjust a width dimension of a first part of the core assembly to match a width of the frame, and a plurality of tire pad shims to adjust a width dimension of a second part of the core assembly to match the width of the frame. The core assembly, the plurality of flange shims, and the plurality of tire pad shims are each configured to bolt to each other and the core assembly is configured to bolt to the frame. The first part of the core assembly can include a bar. The second part of the core assembly can include a support tube or bumper.

Abstract: Neutron shielding. The neutron shielding comprises a plurality of absorption layers, and at least one moderating layer. The plurality of absorption layers each comprise tungsten boride or tungsten carbide. The at least one moderating layer comprises a metal hydride. Each moderating layer is between at least two absorption layers.

Abstract: Neutron shielding. The neutron shielding comprises a plurality of absorption layers (201, 203), and at least one moderating layer (202). The plurality of absorption layers each comprise tungsten boride or tungsten carbide. The at least one moderating layer comprises a metal hydride. Each moderating layer is between at least two absorption layers.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A device for removing material from a vasculature includes a rotation subassembly having a first central axis and a first gear, a valve subassembly having the first central axis and being adjacent to the rotation subassembly, and an actuation system having a second central axis and a second gear. The rotation subassembly is coupled to a catheter to rotate the catheter. The valve subassembly is configured to selectively allow flow of the material from the catheter to the device. The actuation system configured to actuate rotation of the rotation subassembly. The first central axis and the second central axis are parallel.

Abstract: New material compositions, designs and configurations for components for an apparatus that produces a neutron flux such as a nuclear fusion reactor, and methods of manufacturing said new components.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: New breeder blanket designs and configurations for use in a nuclear fusion reactor to breed Tritium fuel are presented. The breeder blanket designs consist of steel conduits made of different sections, formed of different steels, which are used for the circulation of liquid breeder material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: Neutron shielding comprising a metal-hydride metal composite: the metal-hydride metal composite comprising: a metal matrix; and a plurality of metal-hydride particles dispersed within the metal matrix; wherein, the fraction of metal-hydride in the metal-hydride metal composite is at least 1 mol % and the volume fraction of metal-hydride in the metal hydride metal composite is no higher than the ratio of the solid solubility limit of hydrogen in the metal matrix and the molar fraction of hydrogen in the metal-hydride.

Abstract: A breeder blanket for generating tritium using neutrons produced by nuclear fusion of deuterium and/or tritium within a plasma confined within a fusion reactor. The breeder blanket comprises: a plasma-facing first wall; a breeder layer comprising lithium containing material for generating tritium from the neutrons; and neutron moderator material comprising metal hydride and/or deuteride arranged between the first wall and the lithium-containing material.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: A breeder blanket for generating tritium using neutrons produced by nuclear fusion of deuterium and/or tritium within a plasma confined within a fusion reactor. The breeder blanket comprises: a plasma-facing first wall; a breeder layer comprising lithium containing material for generating tritium from the neutrons; and neutron moderator material comprising metal hydride and/or deuteride arranged between the first wall and the lithium-containing material.

Abstract: Devices and methods may allow for the removal of material from a remote location in the vasculature. In an example of such a remote location, the device may be used in the vasculature of a lower extremity in combination with an external cuff. The external cuff may create a dam preventing material from flowing throughout the body. With the external cuff in place, the device of the present disclosure may be utilized to suction the material from the vasculature while rotating the catheter to assist in the removal of the material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.