Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: An iterative design environment performs an iterative design process of a product by implementing usage feedback of the product when utilized under real-world conditions. Sensors are installed on the physical product and collect data about the behavior of the product under real-world conditions. The sensor data comprise usage feedback implemented to inform and produce a design problem statement and one or more design solutions. The sensor data is received by a problem statement engine to produce a problem statement based, at least in part, on the sensor data. A design engine then produces one or more design solutions for the problem statement and one of the design solutions is fabricated to produce a new physical product. Sensors are then installed onto the new physical product and the iterative design process may be performed again. The iterative design process may be performed multiple times until a satisfactory physical product is achieved.

Abstract: A wakeboat includes a hull; a thruster associated with the hull of the wakeboat, the thruster configured to selectively impart lateral force to the hull; an operator control in the wakeboat configured to control a parameter of the wakeboat other than the thruster; a thruster control associated with the operator control, the thruster control selectively receiving input from the operator to control the thruster, the thruster control positioned to be operable with at least the same hand and/or fingers already operating the operator control. Other systems and methods for controlling a wakeboat are also provided.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A design application is configured to determine design problem geometry and design criteria associated with a design problem to be solved. Based on this information, the design application identifies one or more design approaches to creating a custom material having specific material attributes needed to solve the design problem. The design application then executes the design approaches to create material designs that reflect one or more custom materials. With these designs as input, a manufacturing machine may then construct physical instances of those custom materials. A given custom material may have a unique combination of material attributes potentially not found among existing materials. Additionally, a design fabricated from a custom material may better satisfy the design criteria than a design fabricated from a known material.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: A design application interacts with an end-user to generate design problem geometry that reflects a design problem to be solved. Various design objectives, design constraints, boundary conditions, and other design criteria may be associated with the design problem geometry via the design application. When the design problem is sufficiently well defined, a client-side solver generates a solution approximation using a coarse multi-objective solver. The client-side solver favors speed over accuracy, and so the solution approximation provides only a rough representation of various attributes of potentially feasible design solutions. Based on the solution approximation, the end-user may correct any omissions, mistakes, and so forth, before executing pay-per-service cloud-based parallel solver.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

Abstract: A design application includes a design engine and a tracking engine. The design engine allows end-users to create and modify a design space. The design space includes a spectrum of possible design options, as well as other information related to the process of creating designs. When changes are applied to the design space, the design engine transmits event data to the tracking engine that reflects those changes. The tracking engine, based on the event data, updates a design space timeline. The design space timeline illustrates the evolution of the design space over time.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens. In some embodiments, an optical window is disposed in the hollow chamber and is optically coupled to the output surface of the lens such that the light exiting the lens passes through the optical window before exiting the light module. In some embodiments, the shoulder can be formed as part of the housing.

Abstract: A design application allows an end-user to define an engineering problem, and then synthesizes a spectrum of design options that solve the engineering problem. The design application then generates various tools to allow the end-user to explore that spectrum of design options. The design application allows the end-user to compare various attributes of each design option, and to filter the spectrum of design options based on those attributes. In response to end-user selections of certain design options, the design application identifies other similar design options, and then displays these design options to the end-user.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: An embodiment of the invention provides a method for determining a patient-specific probability of disease. The method collects clinical parameters from a plurality of patients to create a training database. A fully unsupervised Bayesian Belief Network model is created using data from the training database; and, the fully unsupervised Bayesian Belief Network is validated. Clinical parameters are collected from an individual patient; and, such clinical parameters are input into the fully unsupervised Bayesian Belief Network model via a graphical user interface. The patient-specific probability of the healing rate of an acute traumatic wound is output from the fully unsupervised Bayesian Belief Network model and sent to the graphical user interface for use by a clinician in pre-operative planning. The fully unsupervised Bayesian Belief Network model is updated using the clinical parameters from the individual patient and the patient-specific probability of the healing rate of an acute traumatic wound.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: In one aspect, a light module is disclosed, which includes a housing providing a hollow chamber extending from a proximal end to a distal end, and a lens positioned in the hollow chamber, where the lens has a lens body comprising an input surface for receiving light from a light source and an output surface through which light exits the lens body, said lens further comprising a collar at least partially encircling said lens body. The light module further includes at least one shoulder on which the lens collar can be seated for positioning the lens within the housing. A light source, e.g., an LED, is coupled to the hollow chamber, e.g., at its proximal end, for providing light to the lens.

Abstract: A wakeboat creates a wake, the performance level of the wake varying depending upon the mass of the wakeboat, the wakeboat including a hull; an engine supported by the hull; a controller supported by the hull; a processor coupled to the controller; a memory coupled to the processor; a sensor configured to measure at least one parameter of the wakeboat, the controller being coupled to the sensor and being configured to receive data from the sensor, the controller being configured to derive the present mass of the wakeboat from said sensor data, the controller being configured to determine the present wake performance level of the wakeboat based on the present mass of the wakeboat; and a display coupled to the controller, the controller being configured to use the display to indicate the present wake performance level of the wakeboat.

Abstract: In various embodiments, a workflow application generates and evaluates designs that reflect stylistic preferences. In operation, the workflow application determines a target style based on input received via a graphical user interface (GUI). Notably, the target style characterizes a first set of designs. The workflow application then generates stylized design(s) based on stylization algorithm(s) associated with the target style. Subsequently, the workflow application, displays a subset of the stylized design(s) via the GUI. A stylized design included in the subset of stylized design(s) is ultimately selected for production via the GUI. Advantageously, because the workflow application can substantially increase the number of designs that can be generated and evaluated based on the target style in a given amount of time, relative to more manual prior art techniques, the overall quality of the stylized design selected for production can be improved.