Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A method includes providing a wearable device compatible with and worn by an animal, the wearable device including a processing engine, a plurality of sensors, and a communication interface to a remotely located base station. The method includes monitoring an environment around the wearable device as the animal traverses a space and collecting information based on data generated by the plurality of sensors. The method also includes analyzing the data generated by the plurality of sensors and inferring activities associated with a human in proximity to the animal, wherein inferring activities includes determining a current location of the human based on data generated by one or more of the sensors, and determining activities of the human over a period of time based on data generated by the one or more sensors.

Abstract: A design application generates a spectrum of design options that meet certain design criteria. Each design option may potentially be composed of a different type of material. The design application filters the spectrum of design options for presentation in a graphical user interface (GUI). The GUI illustrates different design options based on material of composition within a parallel axis plot that includes separate axes for different material attributes. The GUI also displays envelopes of design options for each different material or material type, where each envelope has a different color, pattern, opacity, or other visual attribute. A GUI engine dynamically updates the GUI to reflect constraints and other design criteria applied to the spectrum of design options.

Abstract: In one aspect, a handheld lighting system is disclosed, which comprises a handheld housing extending from a proximal end to a distal end, and a light module disposed at least partially in the housing. The handheld lighting system further includes a removable and replaceable power module that is coupled to the housing (e.g., it is at least partially disposed within the housing) and is electrically coupled to the light module, e.g., through a pair of electrical leads, for providing electrical power thereto. Light intensity from the light module may be controlled from a knob on the power module. Various adapters can allow the lighting system to attach to a multitude of medical, industrial, dental or veterinary endoscopes or other instruments.

Abstract: A composite curb for a shower base, and a self-sealing anchoring cap for a shower curb. The composite curb includes a lower-density base portion formed of closed cell foam, and a higher-density anchoring cap portion attached to the base. The self-sealing anchoring cap comprises a resilient or self-healing material or a self-sealing layer, and is configured to retain a fastener therein and form a water-resistant seal between the fastener and the anchoring cap portion.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, facilitate determining information about an object included in an image. In one aspect, a method includes: identifying an image; identifying a specific object included in the image; identifying data associated with the image; determining both a dimension of the specific object and a construction material of the specific object using the identified data; and outputting the dimension and the construction material of the specific object.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: A wakeboat creates a wake, the performance level of the wake varying depending upon the mass of the wakeboat, the wakeboat including a hull; an engine supported by the hull; a controller supported by the hull; a processor coupled to the controller; a memory coupled to the processor; a sensor configured to measure at least one parameter of the wakeboat, the controller being coupled to the sensor and being configured to receive data from the sensor, the controller being configured to derive the present mass of the wakeboat from said sensor data, the controller being configured to determine the present wake performance level of the wakeboat based on the present mass of the wakeboat; anda display coupled to the controller, the controller being configured to use the display to indicate the present wake performance level of the wakeboat.

Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, facilitate determining information about an object included in an image. In one aspect, a method includes: identifying an image; identifying a specific object included in the image; identifying data associated with the image; determining both a dimension of the specific object and a construction material of the specific object using the identified data; and outputting the dimension and the construction material of the specific object.

Abstract: An iterative design environment performs an iterative design process of a product by implementing usage feedback of the product when utilized under real-world conditions. Sensors are installed on the physical product and collect data about the behavior of the product under real-world conditions. The sensor data comprise usage feedback implemented to inform and produce a design problem statement and one or more design solutions. The sensor data is received by a problem statement engine to produce a problem statement based, at least in part, on the sensor data. A design engine then produces one or more design solutions for the problem statement and one of the design solutions is fabricated to produce a new physical product. Sensors are then installed onto the new physical product and the iterative design process may be performed again. The iterative design process may be performed multiple times until a satisfactory physical product is achieved.

Abstract: A single deck shuffler includes a pre-shuffle bin, card-selector assembly, drive wheel and post-shuffle bin. The pre-shuffle bin is configured to accept a single deck of cards. While in the pre-shuffle bin, a modest downward force is applied to the single deck of cards. A base of the pre-shuffle bin is an independent member that selectively raises and lowers the deck of cards pursuant to a randomly-selected card number (e.g., 1-52). Once positioned correctly based on the randomly-selected card number, an upper body of the card-selector assembly moves forward to push a number of cards off the top of the deck corresponding to the randomly-selected card number thereby exposing a bottom card (i.e., the randomly-selected card) to a drive wheel. The drive wheel propels the card from the pre-shuffle bin into the post-shuffle bin. The process is repeated until each card is propelled into the post-shuffle bin.

Abstract: A method includes providing a wearable device compatible with and worn by an animal, the wearable device including a processing engine, a plurality of sensors, and a communication interface to a remotely located base station. The method includes monitoring an environment around the wearable device as the animal traverses a space and collecting information based on data generated by the plurality of sensors. The method also includes analyzing the data generated by the plurality of sensors and inferring activities associated with a human in proximity to the animal, wherein inferring activities includes determining a current location of the human based on data generated by one or more of the sensors, and determining activities of the human over a period of time based on data generated by the one or more sensors.

Abstract: This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.

Abstract: A single deck shuffler includes a pre-shuffle bin, card-selector assembly, drive wheel and post-shuffle bin. The pre-shuffle bin is configured to accept a single deck of cards. While in the pre-shuffle bin, a modest downward force is applied to the single deck of cards. A base of the pre-shuffle bin is an independent member that selectively raises and lowers the deck of cards pursuant to a randomly-selected card number (e.g., 1-52). Once positioned correctly based on the randomly-selected card number, an upper body of the card-selector assembly moves forward to push a number of cards off the top of the deck corresponding to the randomly-selected card number thereby exposing a bottom card (i.e., the randomly-selected card) to a drive wheel. The drive wheel propels the card from the pre-shuffle bin into the post-shuffle bin. The process is repeated until each card is propelled into the post-shuffle bin.

Abstract: An automatic card shuffler to shuffle eight decks of cards (or less) and deal a round of Baccarat. The automatic shuffler comprises two pre-shuffle bins, each receiving approximately four decks of cards wherein the pre-shuffle bins are spaced apart from one another with card slides directing to a card-receiving area. Cards are randomly selected from the cards in each of the pre-shuffle bins and propelled onto the card slides directing the cards to the card-receiving area. Once a sufficient number of buffer cards (e.g., seven) have been deposited into the card-receiving area, a card flipper moves the seven cards against a face plate of an integral dealing shoe. A buffer-holder member maintains the buffer cards against the face plate for dealing as the card flipper returns to a home position to receive more shuffled cards while buffer cards are being dealt in a round of Baccarat.

Abstract: Methods, systems and compositions for recovery of regenerant ions from spent regenerant solution by utilization of electrodialysis are provided. For example, in certain aspects methods for separating spent regenerant using an electrodialysis system comprising selective membranes are described. Furthermore, the invention provides methods for treating a friable solid ion-removal material to prevent fragmentation during regeneration.

Abstract: A sensor for detecting the breakthrough of hardness in a water softener measures a change in the conductivity of elongated cation-exchange material in contact with the treated water.

Abstract: This invention provides methods for treating cancer in a subject comprising administering to the subject an anti-PD-1 antibody and an anti-CD27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.