Patents by Inventor Thomas E. Jenkins

Thomas E. Jenkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carrier modulating accelerometer
    Patent number: 8291765
    Abstract: An accelerometer module for measuring acceleration in a stabilized platform system includes a power supply configured to accept an input AC reference signal and to generate a regulated DC signal and a reference signal in phase with the input AC reference signal; an accelerometer configured to receive the regulated DC signal from said power supply and to generate an output signal in response to an external force acting on the accelerometer module and an analog multiplier unit configured to receive the output signal from the accelerometer and the reference signal from the power supply, and to modulate the reference signal with the output signal so as to output a modulated accelerometer signal. A method for servicing a stabilized platform system comprising is also provided.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: October 23, 2012
    Assignee: Raytheon Company
    Inventors: Michael L. Wells, Thomas E. Jenkins, Carl P. Chaplin, Hongthu K. Nguyen
  • Compositions Comprising Enzyme-Cleavable Ketone-Modified Opioid Prodrugs and Optional Inhibitors Thereof
    Publication number: 20120230916
    Abstract: A method of providing a patient with controlled release of ketone-containing opioid using a prodrug capable, upon enzymatic activation and intramolecular cyclization, of releasing the ketone-containing opioid is disclosed. The disclosure also provides such prodrug compounds and pharmaceutical compositions comprising such compounds. Such pharmaceutical compositions can optionally include an enzyme inhibitor that interacts with the enzyme(s) to mediate the enzymatically-controlled release of the ketone-containing opioid from the prodrug so as to modify enzymatic cleavage of the prodrug. Also included are methods to use such compounds and pharmaceutical compositions.
    Type: Application
    Filed: April 21, 2010
    Publication date: September 13, 2012
    Inventors: Thomas E. Jenkins, Craig O. Husfeld, Julie D. Seroogy, Jonathan W. Wray
  • COMPOSITIONS FOR REDUCING RISK OF ADVERSE EVENTS CAUSED BY DRUG-DRUG INTERACTIONS
    Publication number: 20120232066
    Abstract: The present disclosure provides a composition comprising a GABAA agonist and a GI enzyme inhibitor. The present disclosure also provides a composition comprising (a) a GI enzyme inhibitor and (b) a first drug that interacts with a second drug to produce an adverse effect when the second drug is co-ingested as a GI enzyme-cleavable prodrug with the first drug. Such an interaction can be additive or synergistic.
    Type: Application
    Filed: March 8, 2012
    Publication date: September 13, 2012
    Inventors: Thomas E. JENKINS, Alex Gregory Sturmer
  • Stereoisomers propofol therapeutic compounds
    Patent number: 8242315
    Abstract: A (+)-stereoisomer of formula (I): wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: August 14, 2012
    Assignee: Singature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Therapeutic Compounds
    Publication number: 20120196939
    Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or pro drug thereof, is useful as an anesthetic.
    Type: Application
    Filed: April 2, 2012
    Publication date: August 2, 2012
    Inventor: Thomas E. Jenkins
  • Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug
    Publication number: 20120178772
    Abstract: The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
    Type: Application
    Filed: January 9, 2012
    Publication date: July 12, 2012
    Inventors: Thomas E. Jenkins, Craig O. Husfeld
  • Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug
    Publication number: 20120178773
    Abstract: The embodiments provide Compound KC-7, N-1-[(S)-2-(oxycodone-6-enol-carbonyl-methyl-amino)-2-carbonyl-sarcosine-ethyl amine]-arginine-glycine-acetate, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the \compositions comprise a prodrug, Compound KC-7, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
    Type: Application
    Filed: January 9, 2012
    Publication date: July 12, 2012
    Inventors: Thomas E. Jenkins, Craig O. Husfeld
  • Controlled release of phenolic opioids
    Patent number: 8217005
    Abstract: A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 10, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventors: Thomas E. Jenkins, Aleksandr Kolesnikov
  • N-17-Alkylated Prodrugs of Opioids
    Publication number: 20120142718
    Abstract: Compounds of formula (II) R1R2R3N+—(C(R1a)(R2a))—Ar—Z—C(O)—Y—(C(R1)(R2))n—N—(R3)(R4)A?II, in which R1R2R3N+, R1a, R2a, Ar, Z, Y, R1, R2, n, R3, R4 and A? have the meanings given in the specification, are useful as prodrugs for opioids (Example 13).
    Type: Application
    Filed: February 15, 2008
    Publication date: June 7, 2012
    Inventors: Thomas E. Jenkins, Aleksandr Kolesnikov
  • Therapeutic compounds
    Patent number: 8173849
    Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: May 8, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Prodrugs of active agents
    Patent number: 8163701
    Abstract: Disclosed herein are prodrugs of active agents which contain at least one amine, phenol, carboxylic acid, or thiol functionality. Also disclosed herein are methods of making prodrugs of active agents, pharmaceutical compositions of prodrugs of active agents and methods of using prodrugs of active agents and pharmaceutical compositions.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: April 24, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Stereoisomers Propofol Therapeutic Compounds
    Publication number: 20120035271
    Abstract: A (?)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Inventor: Thomas E. Jenkins
  • Therapeutic compounds
    Patent number: 8071818
    Abstract: A (?)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: December 6, 2011
    Assignee: PharmacoFore, Inc.
    Inventor: Thomas E. Jenkins
  • Pharmaceutical Compositions with Attenuated Release of Phenolic Opioids
    Publication number: 20110281886
    Abstract: Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
    Type: Application
    Filed: October 16, 2009
    Publication date: November 17, 2011
    Inventors: Thomas E. Jenkins, Julie D. Seroogy, Jonathan W. Wray
  • COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF
    Publication number: 20110262355
    Abstract: Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 27, 2011
    Inventors: Thomas E. Jenkins, Craig O. Husfeld, Julie D. Seroogy, Jonathan W. Wray
  • COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF
    Publication number: 20110262359
    Abstract: The present disclosure provides pharmaceutical compositions, and their methods of use, where the pharmaceutical compositions comprise a prodrug that provides enzymatically-controlled release of a drug and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the drug from the prodrug so as to attenuate enzymatic cleavage of the prodrug. The disclosure provides pharmaceutical compositions which comprise an enzyme inhibitor and a prodrug that contains an enzyme-cleavable moiety that, when cleaved, facilitates release of the drug.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 27, 2011
    Inventors: Thomas E. Jenkins, Craig O. Husfeld, Julie D. Seroogy, Jonathan W. Wray
  • Compositions Comprising Enzyme-Cleavable Phenol-Modified Opioid Prodrugs and Inhibitors Thereof
    Publication number: 20110262360
    Abstract: Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 27, 2011
    Inventors: Thomas E. Jenkins, Craig O. Husfeld, Julie D. Seroogy, Jonathan W. Wray
  • Pharmaceutical compositions of short-acting sedative hypnotic agent
    Patent number: 7981931
    Abstract: The invention provides pharmaceutical compositions comprising a phenylacetic acid ester compound useful for inducing or maintaining general anesthesia or sedation in mammals, methods for preparing such compositions, and methods for inducing or maintaining anesthesia or sedation using such compositions.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 19, 2011
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Jennifer Bolton
  • Anesthetic Compounds
    Publication number: 20110124685
    Abstract: The invention provides novel phenolic ester local anesthetic compounds. The invention also provides pharmaceutical compositions that include such compounds as well as methods for making such compounds and compositions and methods for using such compounds and compositions to induce and/or maintain anesthesia and/or analgesia.
    Type: Application
    Filed: January 13, 2009
    Publication date: May 26, 2011
    Inventor: Thomas E. Jenkins
  • Short-acting sedative hypnotic agents for anesthesia and sedation
    Patent number: 7939689
    Abstract: The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: May 10, 2011
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Sabine Axt, Jennifer Bolton