Patents by Inventor Thomas E. Jenkins

Thomas E. Jenkins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Short-acting sedative hypnotic agents for anesthesia and sedation
    Patent number: 6887866
    Abstract: The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: May 3, 2005
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Sabine Axt, Jennifer Bolton
  • Novel calcium channel drugs and uses
    Publication number: 20040242561
    Abstract: Novel multibinding compounds are disclosed. The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel, thereby modulating the biological activities thereof.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 2, 2004
    Inventors: Yu-Hua Ji, Maya Natarajan, John H. Griffin, Thomas E. Jenkins
  • Substituted phenol compounds useful for anesthesia and sedation
    Patent number: 6815555
    Abstract: The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or sedation in a mammal using substituted phenol compounds.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: November 9, 2004
    Assignee: Theravance, Inc.
    Inventors: Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu, Jennifer Bolton
  • Controlling wastewater treatment processes
    Publication number: 20040112829
    Abstract: Methods and apparatus for continuing, automated control of wastewater treatment processes. In certain preferred embodiments, method and apparatus for control of aeration in suspended growth biological treatment processes, especially in activated sludge processes.
    Type: Application
    Filed: September 23, 2003
    Publication date: June 17, 2004
    Inventors: Thomas E. Jenkins, David T. Redmon, Timothy D. Hilgart, Juan De Dios Trillo Monsoriu, Ian Trillo Fox
  • Novel therapeutic agents that modulate enzymatic processes
    Publication number: 20040023290
    Abstract: Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate or enzyme cofactor thereby modulating the biological processes/functions thereof.
    Type: Application
    Filed: June 3, 2002
    Publication date: February 5, 2004
    Inventors: John H. Griffin, J. Kevin Judice, Burton G. Christensen, Thomas E. Jenkins
  • Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
    Publication number: 20030212120
    Abstract: Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
    Type: Application
    Filed: March 14, 2003
    Publication date: November 13, 2003
    Applicants: Axys Pharmaceuticals, Inc., ARRIS PHARMACEUTICAL CORPORATION a Delaware Corporation
    Inventors: Timothy J. Church, Neil Scott Cutshall, Anthony R. Gangloff, Thomas E. Jenkins, Martin S. Linsell, Joane Litvak, Kenneth D. Rice, Jeffrey R. Spencer, Vivian R. Wang
  • Short-acting sedative hypnotic agents for anesthesia and sedation
    Publication number: 20030153554
    Abstract: The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals.
    Type: Application
    Filed: January 24, 2003
    Publication date: August 14, 2003
    Inventors: Thomas E. Jenkins, Sabine Axt, Jennifer Bolton
  • Substituted phenol compounds useful for anesthesia and sedation
    Publication number: 20030119790
    Abstract: The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or sedation in a mammal using substituted phenol compounds.
    Type: Application
    Filed: September 26, 2002
    Publication date: June 26, 2003
    Inventors: Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu, Jennifer Bolton
  • Local anesthetic compounds and uses
    Patent number: 6576791
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 3, 2000
    Date of Patent: June 10, 2003
    Assignee: Theravance, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold N. Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
  • Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
    Patent number: 6562854
    Abstract: Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: May 13, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Timothy J. Church, Neil Scott Cutshall, Anthony R. Gangloff, Thomas E. Jenkins, Martin S. Linsell, Joane Litvak, Kenneth D. Rice, Jeffrey R. Spencer, Vivian R. Wang
  • Methods for identifying novel multimeric agents that modulate receptors
    Publication number: 20030087306
    Abstract: Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker or linkers which may be the same of different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation or disruption of the biological processes/functions of the cell. Also disclosed is a method for identifying such novel multi-binding compounds which bind cellular receptors and a method for generating a mixture of such novel multi-binding compounds.
    Type: Application
    Filed: December 13, 2001
    Publication date: May 8, 2003
    Inventors: Burton G. Christensen, John H. Griffin, Thomas E. Jenkins, J. Kevin Judice
  • NOVEL CALCIUM CHANNEL DRUGS AND USES
    Publication number: 20030073127
    Abstract: Novel multibinding compounds are disclosed. The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca++ channel , thereby modulating the biological activities thereof.
    Type: Application
    Filed: December 8, 1999
    Publication date: April 17, 2003
    Inventors: YU-HUA JI, MAYA NATARAJAN, JOHN H. GRIFFIN, THOMAS E. JENKINS
  • Novel therapeutic agents for macromolecular structures
    Publication number: 20030060663
    Abstract: Disclosed are novel multibinding compounds (agents) which bind macromolecular structures including cellular, extracellular, and microbial components derived from vectors, viruses, fungi, yeasts, bacteria, and the like. The compounds of this invention comprise a plurality of ligands each of which can bind to such macromolecular structures thereby modulating the biological processes/functions thereof. Each of the ligands is covalently attached to a linker (framework) to provide for the multibinding compound. The linker is selected such that the multibinding compound so constructed demonstrates increased modulation or disruption of the biological processes/functions of cell as compared to the aggregate of the individual units of the ligand.
    Type: Application
    Filed: March 8, 2002
    Publication date: March 27, 2003
    Inventors: John H. Griffin, Burton G. Christensen, Thomas E. Jenkins, J. Kevin Judice
  • Novel therapeutic agents for membrane transporters
    Publication number: 20030044845
    Abstract: Novel multi-binding compounds (agents) are disclosed which bind cell membrane transporters including ion channels, molecular transporters and ion pumps. The compounds of this invention comprise from 2 to 10 ligands each of which can bind to such cellular transporters to modulate the biological processes/functions thereof. Each of the ligands is covalently attached to a linker (framework) to provide for a multi-binding compound. The linker is selected such that the multi-binding compound exhibits increased modulation of the biological processes/functions of the transporter as compared to the aggregate of the individual ligand units made available for binding to the transporter.
    Type: Application
    Filed: February 13, 2002
    Publication date: March 6, 2003
    Inventors: Thomas E. Jenkins, Burton G. Christensen, John H. Griffin, J. Kevin Judice
  • Derivatives of glycopeptide antibacterial agents
    Patent number: 6518242
    Abstract: Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrate thereby modulating the biological processes/functions thereof.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: February 11, 2003
    Assignee: Theravance, Inc.
    Inventors: Qi-Qi Chen, John H. Griffin, Thomas E. Jenkins, J. Kevin Judice, Martin S. Linsell, Michael R. Leadbetter
  • Local anesthetic compounds and uses
    Patent number: 6495681
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 17, 2000
    Date of Patent: December 17, 2002
    Assignee: Theravance Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, Witold Hruzewicz, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice
  • Sodium channel drugs and uses
    Patent number: 6479498
    Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: November 12, 2002
    Assignee: Theravance, Inc.
    Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins, David C. Green
  • Local anesthetic compounds and uses
    Patent number: 6462034
    Abstract: Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: October 8, 2002
    Assignee: Theravance, Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, J. Kevin Judice, Huiwei Wu, Witold Hruzewicz
  • Local anesthetic compounds
    Patent number: 6436919
    Abstract: This invention is directed to novel local anesthetic compounds, pharmaceutical compositions containing these compounds, methods of use and methods of preparing these compounds.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 20, 2002
    Assignee: Theravance Inc.
    Inventors: Sabine M. Axt, Timothy J. Church, John R. Jacobsen, Thomas E. Jenkins, Yu-Hua Ji, Huiwei Wu
  • Sodium channel drugs and uses
    Patent number: 6420354
    Abstract: The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+ channel, thereby modulating the biological activities thereof.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: July 16, 2002
    Assignee: Advanced Medicine, Inc.
    Inventors: Daniel Marquess, Seok-Ki Choi, David T. Beattie, John H. Griffin, Scott Armstrong, Timothy J. Church, Thomas E. Jenkins