Abstract: A glass substrate with modified surface regions is disclosed. The glass substrate includes a first side and an opposite second side, an alkali-containing bulk disposed between the first and second sides, and a first alkali-depleted region formed in the alkali-containing bulk on the first side. The first alkali-depleted region defines at least a portion of a first topographical feature. The first topographic feature includes a height that extends in a first direction from a base portion of the first topographical feature to an outermost portion of the first topographical feature. The first direction is oriented parallel to a thickness of the glass substrate between the first and second sides. The first topographic feature also includes a width that extends in a second direction between at least two, spaced apart wall portions of the first topographical feature. The second direction is oriented normal to the first direction.

Abstract: A glass substrate with modified surface regions is disclosed. The glass substrate includes an alkali-containing bulk, a first alkali-depleted region, a second alkali-depleted region, and a first ion-exchanged region. The alkali-containing bulk has a first surface and a second surface with the first and second surfaces on opposite sides. The first alkali-depleted region extends into the alkali-containing bulk from the first surface. The second alkali-depleted region extends into the alkali-containing bulk from the second surface. The first ion-exchanged region extends into the alkali-containing bulk from the first surface. The first alkali-depleted region, the second alkali-depleted region, and the first ion-exchanged region each have a substantially homogenous composition. A method of forming the glass substrate is disclosed. The method includes simultaneously forming the first alkali-depleted region and the first ion-exchanged region in the first surface.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: Glass articles including one or more 3D printed surface features attached to a surface of a substrate at a contact interface between the 3D printed surface feature and the surface. The 3D printed surface feature(s) include a glass or a glass-ceramic, a compressive stress region at an exterior perimeter surface of the 3D printed surface feature(s), and a central tension region interior of the compressive stress region. The 3D printed surface feature(s) may be formed of a contiguous preformed material 3D printed on a surface of a substrate. The compressive stress region of a 3D printed surface feature may be formed using an ion-exchange process.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: A method includes heating a glass preform having a plurality of glass layers and drawing the glass preform in a distal direction to form a drawn glass sheet extending distally from the glass preform and having the plurality of glass layers. The drawn glass sheet is thinner than the glass preform. The drawn glass sheet can be rolled onto a collection spool. At least a portion of a glass layer can be removed from the drawn glass sheet. An exemplary glass sheet includes a first glass layer, a second glass layer adjacent to the first glass layer, and a thickness of at most about 0.1 mm. An exemplary ion exchanged glass sheet includes a thickness of at most about 0.1 mm and a surface layer that is under a compressive stress and extends into an interior of the glass sheet to a depth of layer.

Abstract: A method of making a glass sheet comprises laminating a high CTE core glass to a low CTE clad glass at high temperatures and allowing the laminate to cool creating compressive stress in the clad glass, and then ion exchanging the laminate to increase the compressive stress in the outer near surface regions of the clad glass. The core glass may include ions that exchange with ion in the clad glass to increase the compressive stress in inner surface regions of the clad glass adjacent to the clad glass/core glass interfaces. The glass laminate may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: A method for forming a structure includes providing a glass or glass ceramic tubular structure (110) having an interior (150) and exterior surface (160) and at least a partially closed end region (140); heating the glass or glass ceramic tubular structure (110) to at least its softening point by: providing a laser beam; directing the laser beam (130) down the interior surface of the glass or glass ceramic tubular structure (110), at least some of the laser beam (130) directed at an angle greater than a predetermined incidence angle; and the laser beam (130) impinging on the closed end region (140) where at least some of the laser beam (130) is absorbed by the closed end region (140) of the glass or glass ceramic tubular structure; and moving at least one of: the glass or glass ceramic tubular structure or the end region relative to each other to form at least a two-dimensional shape from the glass or glass ceramic tubular structure.

Abstract: An apparatus for continuous electro-thermal poling of glass or glass ceramic material, includes a lower support conveying and contacting electrode structure, an upper contacting electrode structure positioned above the lower support structure, and one or more DC bias voltage sources connected to one or both of the upper contacting structure and the lower support structure. A process for continuous electro-thermal poling of glass or glass ceramic sheets or substrates includes heating the sheet or substrate, feeding the sheet or substrate continuously or continually, while applying a DC voltage bias, and cooling the sheet or substrate to within 0-30° C. of ambient temperature.

Abstract: A method includes heating a glass preform having a plurality of glass layers and drawing the glass preform in a distal direction to form a drawn glass sheet extending distally from the glass preform and having the plurality of glass layers. The drawn glass sheet is thinner than the glass preform. The drawn glass sheet can be rolled onto a collection spool. At least a portion of a glass layer can be removed from the drawn glass sheet. An exemplary glass sheet includes a first glass layer, a second glass layer adjacent to the first glass layer, and a thickness of at most about 0.1 mm. An exemplary ion exchanged glass sheet includes a thickness of at most about 0.1 mm and a surface layer that is under a compressive stress and extends into an interior of the glass sheet to a depth of layer.

Abstract: A method of printing a 3D object includes feeding one or more preformed materials from a feed outlet into a build zone in which a hot spot is located and using the hot spot to selectively heat the one or more preformed materials to a viscous state. Object layers are formed by depositing portions of the preformed materials on a build surface, or on another object layer on the build surface, while effecting relative motion between the build surface and the feed outlet.

Abstract: A method of making a glass sheet comprises laminating a high CTE core glass to a low CTE clad glass at high temperatures and allowing the laminate to cool creating compressive stress in the clad glass, and then ion exchanging the laminate to increase the compressive stress in the outer near surface regions of the clad glass. The core glass may include ions that exchange with ion in the clad glass to increase the compressive stress in inner surface regions of the clad glass adjacent to the clad glass/core glass interfaces. The glass laminate may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: A method of manufacturing a laminated glass article having a first clad layer, a second clad layer, and a core layer between the first clad layer and the second clad layer, by exposing an edge of the core layer. An etchant can be applied to the edge of the laminated glass article to form the recess. The recess can then be filled.

Abstract: Computer systems and methods are provided for tracking a user. Data for a first user, including a first identifier associated with the first user, is received. A first tracking program for the first user that includes a first identifier associated with the first user, a first indicated area for a first user device, associated with the first user and a first time period when the first user is scheduled to be located within the first indicated area is generated and stored. At a first time that corresponds to the first time period, a position detection system determines a first determined position of the first user device. The first determined position of the first user device is compared with the first indicated area. In accordance with a determination that the first determined position of the first user device does not correspond to the first indicated area a first tracking alert is transmitted.

Abstract: Methods, apparatus, computing devices, computing entities, and/or the like associated with a robotic sortation system are provided. An example method may include receiving imaging data associated with a first item at a first sorting location of a material handling system, determining a sorting destination for the first item based at least in part on the imaging data, determining a plurality of first-tier robotic devices and a plurality of second-tier robotic devices based at least in part on the first sorting location and the sorting destination, and generating a first sortation scheme for the first item.

Abstract: A apparatus for making a three-dimensional object that includes: a gripping fixture having a grip surface or a pedestal having a build surface, the grip or build surface configured to hold an end of a contiguous, preformed material; a feed system having a feed outlet positioned above the grip or build surface, the feed system configured to feed the contiguous, preformed material into a build zone between the feed outlet and the grip or build surface; and a laser delivery system arranged to direct at least one laser beam through the furnace and into the build zone to form a hot spot in the build zone; and a positioning system arranged to effect relative motion between the grip or build surface and the feed outlet. In some implementations, the apparatus for making a 3D object can also include a furnace enclosing the build zone and the feed outlet.

Abstract: A apparatus for making a three-dimensional object (glass, glass ceramic or ceramic) that includes: a gripping fixture 102a having a grip surface or a pedestal 102 having a build surface 130, the grip or build surface configured to hold an end of a contiguous, preformed material 106, such as a fiber or a ribbon; a feed system 100 having a feed outlet 118 positioned above the grip or build surface, the feed system configured to feed the contiguous, preformed material into a build zone between the feed outlet and the grip or build surface; and a laser delivery system 134 arranged to direct at least one laser beam through the furnace 132 and into the build zone to form a hot spot 126 in the build zone; and a positioning system 120 arranged to effect relative motion between the grip or build surface and the feed outlet. In some implementations, the apparatus for making a 3D object can also include a furnace 132 enclosing the build zone and the feed outlet.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.