Abstract: The present invention relates to antibodies specific for one or more antigens, bispecific antibodies containing one or more domains with specificity to the target(s), and to immunocytokines. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: An apparatus for forming glass tubing is described. The apparatus for forming glass tubing comprises an endless former with an outer surface and an inner passage defining an inner surface. The apparatus for forming glass tubing further comprises two chambers from which molten glass may flow. One chamber flows molten glass to the outer surface of the endless former and another chamber flows molten glass to the inner surface of the endless former. The two flows of molten glass meet at the bottom of the former to form glass tubing.

Abstract: A apparatus for making a three-dimensional object (glass, glass ceramic or ceramic) that includes: a gripping fixture 102a having a grip surface or a pedestal 102 having a build surface 130, the grip or build surface configured to hold an end of a contiguous, preformed material 106, such as a fiber or a ribbon; a feed system 100 having a feed outlet 118 positioned above the grip or build surface, the feed system configured to feed the contiguous, preformed material into a build zone between the feed outlet and the grip or build surface; and a laser delivery system 134 arranged to direct at least one laser beam through the furnace 132 and into the build zone to form a hot spot 126 in the build zone; and a positioning system 120 arranged to effect relative motion between the grip or build surface and the feed outlet. In some implementations, the apparatus for making a 3D object can also include a furnace 132 enclosing the build zone and the feed outlet.

Abstract: An apparatus for forming glass tubing is described. The apparatus for forming glass tubing comprises an endless former with an outer surface and an inner passage defining an inner surface. The apparatus for forming glass tubing further comprises two chambers from which molten glass may flow. One chamber flows molten glass to the outer surface of the endless former and another chamber flows molten glass to the inner surface of the endless former. The two flows of molten glass meet at the bottom of the former to form glass tubing.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: A handling strut connects the powertrain of an automobile to a structural member, such as a panel in the engine bay. The handling strut is comprised of two strut members, one connected to the powertrain, the other connected to the structural member. A shaft attached to one strut member, extends through a bushing provided in the other strut member and an air gap is provided between the bushing and the shaft, such that when the engine is idle, or not accelerating, and in the absence of hard cornering, the strut members are decoupled. The isolation of the strut members when not required to control engine roll, reduces/avoids transmission of noise, vibration and/or harshness.

Abstract: Multispecific antibody having a binding site for ICOS and a binding site for a second antigen, e.g., an immune checkpoint molecule such as PD-L1. Use of the multispecific antibody in immuno-oncology, including for treatment of solid tumours.

Abstract: A method of making a glass sheet comprises laminating a high CTE core glass to a low CTE clad glass at high temperatures and allowing the laminate to cool creating compressive stress in the clad glass, and then ion exchanging the laminate to increase the compressive stress in the outer near surface regions of the clad glass. The core glass may include ions that exchange with ion in the clad glass to increase the compressive stress in inner surface regions of the clad glass adjacent to the clad glass/core glass interfaces. The glass laminate may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: A method of manufacturing a laminated glass article having a first clad layer, a second clad layer, and a core layer between the first clad layer and the second clad layer, by exposing an edge of the core layer. An etchant can be applied to the edge of the laminated glass article to form the recess. The recess can then be filled.

Abstract: A method of manufacturing a laminated glass article having a first clad layer, a second clad layer, and a core layer between the first clad layer and the second clad layer, by exposing an edge of the core layer. An etchant can be applied to the edge of the laminated glass article to form the recess. The recess can then be filled.

Abstract: A handling strut connects the powertrain of an automobile to a structural member, such as a panel in the engine bay. The handling strut is comprised of two strut members, one connected to the powertrain, the other connected to the structural member. A shaft attached to one strut member, extends through a bushing provided in the other strut member and an air gap is provided between the bushing and the shaft, such that when the engine is idle, or not accelerating, and in the absence of hard cornering, the strut members are decoupled. The isolation of the strut members when not required to control engine roll, reduces/avoids transmission of noise, vibration and/or harshness.

Abstract: Computer systems and methods are provided for tracking a user. Data for a first user, including a first identifier associated with the first user, is received. A first tracking program for the first user that includes a first identifier associated with the first user, a first indicated area for a first user device, associated with the first user and a first time period when the first user is scheduled to be located within the first indicated area is generated and stored. At a first time that corresponds to the first time period, a position detection system determines a first determined position of the first user device. The first determined position of the first user device is compared with the first indicated area. In accordance with a determination that the first determined position of the first user device does not correspond to the first indicated area a first tracking alert is transmitted.

Abstract: A method of making a glass sheet comprises laminating a high CTE core glass to a low CTE clad glass at high temperatures and allowing the laminate to cool creating compressive stress in the clad glass, and then ion exchanging the laminate to increase the compressive stress in the outer near surface regions of the clad glass. The core glass may include ions that exchange with ion in the clad glass to increase the compressive stress in inner surface regions of the clad glass adjacent to the clad glass/core glass interfaces. The glass laminate may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: Glass-based articles having a thickness (t) comprise a glass-based core substrate and at least one cladding substrate directly bonded to the glass-based core substrate. A stress profile may comprise a depth of compression (DOC) where the glass-based article has a stress value of zero, the DOC being located at 0.15·t, 0.18·t, 0.21·t, or deeper. The articles may be formed from one or more cladding substrates formed from cladding sheets having a thickness of at least 0.15·t, 0.18·t, 0.21·t, or more. Consumer electronic products may comprise the glass-based articles. Upon lamination, the articles may optionally be further exposed to heat and/or chemical treatments for further strengthening.

Abstract: Systems and methods for converting grayscale values in magnetic resonance images having different image contrasts into normalized estimations of physiological quantities are provided. These methods provide consistency of data from scan-to-scan, which allows the data to be used for high-fidelity radiogenomic analyses. Imaging-derived radiogenomic heat maps, based on trained models of quantitative radiogenomic associations, can be generated from, the normalized images and can provide a novel technique to survey the often varied genetic landscape within a tumor.

Abstract: A method includes heating a glass preform having a plurality of glass layers and drawing the glass preform in a distal direction to form a drawn glass sheet extending distally from the glass preform and having the plurality of glass layers. The drawn glass sheet is thinner than the glass preform. The drawn glass sheet can be rolled onto a collection spool. At least a portion of a glass layer can be removed from the drawn glass sheet. An exemplary glass sheet includes a first glass layer, a second glass layer adjacent to the first glass layer, and a thickness of at most about 0.1 mm. An exemplary ion exchanged glass sheet includes a thickness of at most about 0.1 mm and a surface layer that is under a compressive stress and extends into an interior of the glass sheet to a depth of layer.

Abstract: A method of printing a 3D object includes feeding one or more preformed materials from a feed outlet into a build zone in which a hot spot is located and using the hot spot to selectively heat the one or more preformed materials to a viscous state. Object layers are formed by depositing portions of the preformed materials on a build surface, or on another object layer on the build surface, while effecting relative motion between the build surface and the feed outlet.