Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: An apparatus for forming glass tubing is described. The apparatus for forming glass tubing comprises an endless former with an outer surface and an inner passage defining an inner surface. The apparatus for forming glass tubing further comprises two chambers from which molten glass may flow. One chamber flows molten glass to the outer surface of the endless former and another chamber flows molten glass to the inner surface of the endless former. The two flows of molten glass meet at the bottom of the former to form glass tubing.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: A method of making a glass sheet comprises laminating a high CTE core glass to a low CTE clad glass at high temperatures and allowing the laminate to cool creating compressive stress in the clad glass, and then ion exchanging the laminate to increase the compressive stress in the outer near surface regions of the clad glass. The core glass may include ions that exchange with ion in the clad glass to increase the compressive stress in inner surface regions of the clad glass adjacent to the clad glass/core glass interfaces. The glass laminate may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines.

Abstract: A method of making a glass sheet (10) comprises laminating a high CTE core glass (11) to a low CTE clad glass (12) at high temperatures and allowing the laminate (10) to cool creating compressive stress in the clad glass (12), and then ion exchanging the laminate (10) to increase the compressive stress in the outer near surface regions of the clad glass (12). The core glass (11) may include ions that exchange with ion in the clad glass (12) to increase the compressive stress in inner surface regions of the clad glass (12) adjacent to the clad glass/core glass interfaces. The glass laminate (10) may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: Push roll spools for engaging and driving softened glass tubes over a shaping mandrel. A push roll spool for use in processing a glass tube may comprise a base having first and second axially spaced ends, and multiple sheets of heat resistant material disposed on the base between the axially spaced ends, forming an axially extending stack. The stack may have a circumferential, generally U-section groove having a profile defined by the peripheral edges of multiple said sheets having different diameters. The U-section groove may be sized to engage and drive a glass tube. The U-section groove may have two contact areas at which to engage and drive a glass tube. The heat resistant material may comprise mica or a mica composition, for example mica paper or ceramic fiber millboard.

Abstract: A method of manufacturing a laminated glass article having a first clad layer, a second clad layer, and a core layer between the first clad layer and the second clad layer, by exposing an edge of the core layer. An etchant can be applied to the edge of the laminated glass article to form the recess. The recess can then be filled.

Abstract: In one embodiment, a pulling roll for drawing glass sheet in a down-draw process includes a shaft member and a compliant cover assembly positioned on the shaft member. The compliant cover assembly includes at least one traction disk positioned on the shaft member. The at least one traction disk includes an annular hub and a plurality of spring elements integrally formed with the annular hub. The spring elements project outward from the annular hub such that an end of each spring element is positioned radially outward from a base of each spring element and is circumferentially offset relative to the base of each spring element.

Abstract: In one embodiment, a pulling roll for drawing glass sheet in a down-draw process includes a shaft member and a compliant cover assembly positioned on the shaft member. The compliant cover assembly includes at least one traction disk and at least one deflection limiting disk positioned on the shaft member. The at least one traction disk includes an annular hub and a plurality of spring elements integrally formed with the annular hub. The at least one deflection limiting disk includes at least one deflection limiting element positioned on each deflection limiting disk. The at least one deflection limiting element engages at least a portion of at least one traction disk upon a predetermined amount of inward radial deflection of the plurality of spring elements, thereby limiting the inward radial deflection of the plurality of spring elements.

Abstract: An exhaust emission reduction system for a fuel injected engine system has a plurality of emission reduction components configured to process the exhaust gas. The emissions reduction components include of one or more NOX reduction components and one or more filtration components configured to reduce particulate matter, hydrocarbons and/or carbon monoxide emissions. Each engine cylinder is associated with a respective one of the emission reduction components, such that exhaust gas from each engine cylinder flows through the respective one emission reduction component in parallel with the exhaust gas flows from the other cylinders through their respective emission reduction components.

Abstract: Pulling rolls for used in forming glass ribbons with reduced defects and cracking are disclosed. In one embodiment, the pulling roll may include a shaft member and a roll assembly. The roll assembly may be positioned on the shaft member for rotation with the shaft member. The roll assembly may include an axially compressed stack of ring elements formed from an inorganic material such as mica paper. The mica paper may include layers of overlapping mica platelets oriented substantially in parallel with one another. A contact surface of the roll assembly may have a Shore D hardness greater than or equal to about 10 and less than or equal to about 60.

Abstract: A method of making a glass sheet (10) comprises laminating a high CTE core glass (11) to a low CTE clad glass (12) at high temperatures and allowing the laminate (10) to cool creating compressive stress in the clad glass (12), and then ion exchanging the laminate (10) to increase the compressive stress in the outer near surface regions of the clad glass (12). The core glass (11) may include ions that exchange with ion in the clad glass (12) to increase the compressive stress in inner surface regions of the clad glass (12) adjacent to the clad glass/core glass interfaces. The glass laminate (10) may be formed and laminated using a fusion forming and laminating process and fusion formable and ion exchangeable glass compositions.

Abstract: In one embodiment, a pulling roll for drawing glass sheet in a down-draw process includes a shaft member and a compliant cover assembly positioned on the shaft member. The compliant cover assembly includes at least one traction disk positioned on the shaft member. The at least one traction disk includes an annular hub and a plurality of spring elements integrally formed with the annular hub. The spring elements project outward from the annular hub such that an end of each spring element is positioned radially outward from a base of each spring element and is circumferentially offset relative to the base of each spring element.

Abstract: In one embodiment, a pulling roll for drawing glass sheet in a down-draw process includes a shaft member and a compliant cover assembly positioned on the shaft member. The compliant cover assembly includes at least one traction disk and at least one deflection limiting disk positioned on the shaft member. The at least one traction disk includes an annular hub and a plurality of spring elements integrally formed with the annular hub. The at least one deflection limiting disk includes at least one deflection limiting element positioned on each deflection limiting disk. The at least one deflection limiting element engages at least a portion of at least one traction disk upon a predetermined amount of inward radial deflection of the plurality of spring elements, thereby limiting the inward radial deflection of the plurality of spring elements.

Abstract: Methods of making a filter apparatus includes the step of creating a filter stack by axially spacing the porous ceramic plates from one another with a plurality of compliant spacers. In another example, the method includes the step of firing the first filter stack to sinter bond the first plurality of porous ceramic plates together with a first spacing element. In another example, the plurality of plates comprise a composition including catalyst particles and a binder material and the plates are fired to form porous plates without sintering a substantial amount of the catalyst particles. Methods of fabricating a porous ceramic article also include providing a porous substrate with a first material composition including mullite and infiltrating the pores of the substrate with a second material composition including cordierite. The method further includes the step of firing the first composition and the second composition to form the porous ceramic article.

Abstract: A filter apparatus comprises a filter stack including a plurality of porous ceramic plates that are axially spaced from one another to define plurality of axially spaced apart radial flow areas. In one example, the filter stack is mounted within a housing. In further examples, the plurality of porous ceramic plates alternate between a first set of porous ceramic plates that are nested with a second set of porous ceramic plates. In still further examples, at least one of the sides of the porous ceramic plates defines a plurality of radial flutes arranged in a radial array.

Abstract: The invention is a solution impregnation and drying treatment that imparts a high temperature binder into an already formed porous green body composed of particulate batch material. The batch material includes inorganic compounds and binder. The result is reduced sag and distortion and the same or increased strength when the porous body is later fused during sintering/firing.