Abstract: A pressure regulating or pressure relief device comprises an inlet and an outlet chamber with an outlet. The inlet is in fluid communication with the outlet chamber. A valve seat is located between the inlet and the outlet. A valve member is biased to seal against the valve seat, and displaces from the valve seat by an inlet pressure at the inlet increasing above a pressure threshold to allow a flow of gases from the inlet to the outlet via the outlet chamber. The flow of gases through the outlet causes an outlet pressure in the outlet chamber to act on the valve member together with the inlet pressure to displace the valve member from the valve seat.

Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

Abstract: A pressure regulating or pressure relief device comprises an inlet and an outlet chamber with an outlet. The inlet is in fluid communication with the outlet chamber. A valve seat is located between the inlet and the outlet. A valve member is biased to seal against the valve seat, and displaces from the valve seat by an inlet pressure at the inlet increasing above a pressure threshold to allow a flow of gases from the inlet to the outlet via the outlet chamber. The flow of gases through the outlet causes an outlet pressure in the outlet chamber to act on the valve member together with the inlet pressure to displace the valve member from the valve seat.

Abstract: This invention relates to a method or system for providing an indication or establishment of airway patency of a patient comprising monitoring of at least one targeted gas (e.g. CO2, N2 or may be other gases capable of being detected, monitored, and measured) that is being expired or being expelled from an airway of a patient (e.g. an apnoeic or non-spontaneously breathing patient), and based on measurements of the at least one targeted gas for a period of time, providing an indicator as to an output of the measurements of the at least one targeted gas for the period of time, or a determination as to airway patency, or a determination as to a location of a blockage or obstruction in the airway, or combinations of these.

Abstract: The invention relates to a freeze dryer and a method for inducing controlled nucleation in liquid products.

Abstract: Battery enclosure arrangements for a vehicular battery system. The arrangements, capable of impact resistance include plurality of battery cells and a plurality of kinetic energy absorbing elements. The arrangements further include a frame configured to encase the plurality of the kinetic energy absorbing elements and the battery cells. In some arrangements the frame and/or the kinetic energy absorbing elements can be made of topologically interlocked materials.

Abstract: A pressure regulating or pressure relief device comprises an inlet and an outlet chamber with an outlet. The inlet is in fluid communication with the outlet chamber. A valve seat is located between the inlet and the outlet. A valve member is biased to seal against the valve seat, and displaces from the valve seat by an inlet pressure at the inlet increasing above a pressure threshold to allow a flow of gases from the inlet to the outlet via the outlet chamber. The flow of gases through the outlet causes an outlet pressure in the outlet chamber to act on the valve member together with the inlet pressure to displace the valve member from the valve seat.

Abstract: A method of determining a duration of safe apnoea. Information is obtained relating to a respiratory indicator, and a duration of safe apnoea is determined from the obtained information. A respiratory therapy system has one or more patient interfaces. A processor is configured to determine a duration of safe apnoea based on obtained information relating to a respiratory indicator.

Abstract: This invention relates to a method or system for providing an indication or establishment of airway patency of a patient comprising monitoring of at least one targeted gas (e.g. CO2, N2 or may be other gases capable of being detected, monitored, and measured) that is being expired or being expelled from an airway of a patient (e.g. an apnoeic or non-spontaneously breathing patient), and based on measurements of the at least one targeted gas for a period of time, providing an indicator as to an output of the measurements of the at least one targeted gas for the period of time, or a determination as to airway patency, or a determination as to a location of a blockage or obstruction in the airway, or combinations of these.

Abstract: A method and system for feeding a lubricating or releasing agent from a dosing station to one or more pressing tools arranged in a pressing chamber of a tablet press. The tablet press is configured with a feed pipe for feeding the lubricating or release agent from the dosing station to the one or more pressing tools of a pressing chamber of the tablet press and the feed pipe is configured with a shut-off valve disposed in-line with the feed pip for controlling the flow of the lubricating or release agent to the pressing chamber. The method comprises the steps of: producing a negative pressure with respect to the surroundings of the pressing chamber of the tablet press, measuring a pressure in one of the feed pipe and the pressing chamber, and issuing a signal indicative of the measured pressure and issuing an enable signal to open a valve in response to the pressure signal.

Abstract: A battery packaging arrangement. The battery packaging arrangement includes a first base configured to be fixedly coupled to a frame of a vehicle, a second base moveable with respect to the first base, and a plurality of cooling columns inter-disposed between the first base and the second base. Each of the plurality of cooling columns includes a plurality of receiving surfaces for receiving a corresponding plurality of battery cells. Each of the plurality of cooling columns is further configured to deform when the second base in response to a force moves towards the first base.

Abstract: An apparatus for oxygenation and/or CO2 clearance of a patient. The apparatus comprising: a flow source or a connection for a flow source for providing a gas flow, a gas flow modulator, a controller to control the gas flow. The controller is operable to: receive input relating to heart activity and/or trachea gas flow of the patient, and control the gas flow modulator to provide a varying gas flow with at least two oscillating components. One oscillating component has a frequency based on the heart activity and/or trachea flow of the patient. One oscillating component has a frequency to: promote bulk gas flow movement, or promote mixing.

Abstract: In one embodiment, there is provided a humidification chamber for use in a medical humidification system. The humidification chamber may comprise: a base and a top linked by a side wall to define the chamber, the chamber being configured to contain a volume of water; a gases inlet configured to receive a gases flow from a gases source; and a gases outlet, wherein the gases inlet is orientated relative to the side wall to introduce the gases flow to the humidification chamber at a direction substantially tangential to the side wall of the humidification chamber.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: This invention relates to a respiratory therapy system comprising a first patient interface for delivery of a flow of gas to a patient, and a second patient interface for delivery of a flow of gas to the patient, or devices or interfaces for use in such systems.

Abstract: The invention relates to a freeze dryer and a method for inducing controlled nucleation in liquid products.

Abstract: Battery enclosure arrangements for a vehicular battery system. The arrangements, capable of impact resistance include plurality of battery cells and a plurality of kinetic energy absorbing elements. The arrangements further include a frame configured to encase the plurality of the kinetic energy absorbing elements and the battery cells. In some arrangements the frame and/or the kinetic energy absorbing elements can be made of topologically interlocked materials.

Abstract: The invention relates to a respiratory system comprising a first patient interface for delivery of a first flow of gases to a patient, a second patient interface for delivery of a second flow of gases to the patient, and a device and/or sensing arrangement that is configure to facilitate a switching of the system between a first respiratory mode where the device allowing delivery of the first flow of gases to an outlet of the first patient interface when the second patient interface is absent from the patient, and a second respiratory mode where the device reducing or stopping delivery of the first flow of gases to the outlet of the first patient interface when the second patient interface is located together with the first patient interface upon the patient.

Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

Abstract: A tamping punch station for filling capsules in a capsule filling machine is described. The machine includes a rotatably drivable dosing disk with bore holes and a filling device for filling the bore holes. Tamping punches and ejection punches are held on a punch support, and vertical movement of the punch support causes the tamping punches to press filling material into the bore holes and the ejection punches to eject pellets created by the tamping punches in the bore holes. A first drive rotates the dosing disk along punches and a second drive moves the punch support. The second drive includes at least two spindle drives acting on the punch support with respectively one spindle nut and respectively one vertical drive spindle guided in the spindle nut and at least two drive motors, which drive respectively one of the spindle drives for vertical movement of the punch support.