Patents by Inventor Thomas J. Meade

Thomas J. Meade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10994016
    Abstract: A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: May 4, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Mark C. Hersam, Thomas J. Meade, Hsiang-Hua Hung
  • Publication number: 20210030896
    Abstract: Provided herein are MRI contrast agents that are conditionally activated by an enzyme from a reporter gene coupled to a gene of interest. In some embodiments, provided herein is a platform where a substrate (blocking access of water to a Gd(III) ion) is removed by an enzyme that can be changed to accommodate a number of gene therapy targets.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Inventors: Thomas J. Meade, Sarah G. Kamper, Michael A. Caldwell, Laura M. Lilley, Hao Li, Ana Rita Batista, Toloo Taghian, Heather L. Gray-Edwards, Miguel Sena-Esteves, Douglas R. Martin
  • Patent number: 10786582
    Abstract: Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: September 29, 2020
    Assignee: Northwestern University
    Inventors: Thomas J. Meade, Matthew W. Rotz, Robert J. Holbrook
  • Publication number: 20200290982
    Abstract: Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Sangeeta Ray, Martin G. Pomper, Thomas J. Meade, Ronnie C. Mease, Ying Chen, Xing Yang, Matthew Rotz
  • Patent number: 10683272
    Abstract: Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: June 16, 2020
    Assignees: THE JOHNS HOPKINS UNIVERSITY, NORTHWESTERN UNIVERSITY
    Inventors: Sangeeta Ray, Martin G. Pomper, Thomas J. Meade, Ronnie C. Mease, Ying Chen, Xing Yang, Matthew Rotz
  • Patent number: 10656229
    Abstract: Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: May 19, 2020
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Thomas J. Meade, Hsiang-Hua Hung
  • Publication number: 20200009271
    Abstract: A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.
    Type: Application
    Filed: September 17, 2019
    Publication date: January 9, 2020
    Inventors: James Basilion, Kirti Dhingra, Thomas J. Meade, Sarah Grace Kamper
  • Publication number: 20190321492
    Abstract: Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
    Type: Application
    Filed: July 5, 2019
    Publication date: October 24, 2019
    Inventors: Thomas J. Meade, Matthew W. Rotz, Robert J. Holbrook
  • Patent number: 10413621
    Abstract: A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.
    Type: Grant
    Filed: October 19, 2010
    Date of Patent: September 17, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James Basilion, Kirti Dhingra, Thomas J. Meade, Sarah Grace Kamper
  • Patent number: 10406249
    Abstract: Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 10, 2019
    Assignee: Northwestern University
    Inventors: Thomas J. Meade, Matthew W. Rotz, Robert J. Holbrook
  • Publication number: 20180221513
    Abstract: Provided herein are compositions and systems comprising contrast-agent (e.g., Gd(III))-labeled peptide amphiphile nanofibers and methods of reporting on biomaterial localization in vivo therewith.
    Type: Application
    Filed: March 16, 2016
    Publication date: August 9, 2018
    Inventors: Adam T. Preslar, Mark Trosper McClendon, Samuel I. Stupp, Thomas J. Meade
  • Publication number: 20170293009
    Abstract: Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.
    Type: Application
    Filed: April 5, 2017
    Publication date: October 12, 2017
    Inventors: Thomas J. Meade, Hsiang-Hua Hung
  • Publication number: 20170081298
    Abstract: Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
    Type: Application
    Filed: May 6, 2015
    Publication date: March 23, 2017
    Applicants: THE JOHNS HOPKINS UNIVERSITY, NORTHWESTERN UNIVERSITY
    Inventors: SANGEETA RAY, MARTIN G. POMPER, THOMAS J. MEADE, RONNIE C. MEASE, YING CHEN, XING YANG, MATTHEW ROTZ
  • Publication number: 20170074859
    Abstract: Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.
    Type: Application
    Filed: August 30, 2016
    Publication date: March 16, 2017
    Inventors: Mark C. Hersam, Thomas J. Meade, Hsiang-Hua Hung
  • Patent number: 9585975
    Abstract: The present invention relates to MRI based imaging. In particular, the present invention provides MRI contrast agents targeted to a HaloTag protein with tunable relaxation properties thereby providing optimal relaxivity for low field strength imaging and the other optimal relaxivity for high field strength imaging. Moreover, the MRI contrast agents are used to detect gene expression (of a gene of interest) in real time in vivo, to detect changes in gene expression (of a gene of interest) over time in, for example, an individual organism, to detect gene expression changes (of a gene of interest) in response to therapeutics, in cell labeling for MR imaging, in clinical diagnostics, and in theranostics.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: March 7, 2017
    Assignee: Northwestern University
    Inventors: Thomas J. Meade, Renee C. Strauch, Luke F. Vistain
  • Patent number: 9566355
    Abstract: The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: February 14, 2017
    Assignee: Northwestern University
    Inventors: Lauren M. Matosziuk, Allison S. Harney, Keith W. MacRenaris, Thomas J. Meade
  • Publication number: 20160375154
    Abstract: Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 29, 2016
    Inventors: Thomas J. Meade, Matthew W. Rotz, Robert J. Holbrook
  • Publication number: 20160031909
    Abstract: Porphyrazines capable of localizing in a tumor of a mammal are disclosed. The porphyrazines are used in methods of imaging a tumor and in methods of treating tumors, either alone or in combination with a chemotherapeutic agent and/or radiation.
    Type: Application
    Filed: March 6, 2014
    Publication date: February 4, 2016
    Inventors: Evan R. Trivedi, Emily A. Waters, Anthony G.M. Barrett, Brian M. Hoffman, Thomas J. Meade
  • Patent number: 9125942
    Abstract: The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 8, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lisa M. Manus, Daniel J. Mastarone, Dean Ho, Thomas J. Meade
  • Publication number: 20150192538
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 9, 2015
    Applicant: OHMX CORPORATION
    Inventors: MICHAEL J. AHRENS, PAUL A. BERTIN, HARRY B. GRAY, THOMAS J. MEADE