Patents by Inventor Thomas J. Meade

Thomas J. Meade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Electrochemical Assay for the Detection of Enzymes
    Publication number: 20120156709
    Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: January 18, 2012
    Publication date: June 21, 2012
    Applicant: OHMX CORPORATION
    Inventors: Paul A. Bertin, Michael Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • Electronic methods for the detection of analytes
    Patent number: 8114661
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: February 14, 2012
    Assignee: Osmetech Technology, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • NOVEL CHEMISTRY USED IN BIOSENSORS
    Publication number: 20120012472
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Application
    Filed: July 20, 2011
    Publication date: January 19, 2012
    Applicant: OHMX CORPORATION
    Inventors: Michael Ahrens, Paul A. Bertin, Harry B. Gray, Thomas J. Meade
  • Compositions and methods for magnetic resonance imaging contrast agents
    Patent number: 8021646
    Abstract: The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that comprise monodisperse, protein polymer backbones capable of chelating multiple paramagnetic ions resulting in high relaxivity for use in enhancing MRI signal intensity.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: September 20, 2011
    Assignee: Northwestern University
    Inventors: Lindsay K. Sulzer, Steven R. Bull, Annelise Emily Barron, Thomas J Meade
  • PARAMAGNETIC METAL-NANODIAMOND CONJUGATES
    Publication number: 20110177008
    Abstract: The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
    Type: Application
    Filed: January 18, 2011
    Publication date: July 21, 2011
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Lisa M. Manus, Daniel J. Mastarone, Dean Ho, Thomas J. Meade
  • Zinc-activated contrast agents
    Patent number: 7906105
    Abstract: The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II) (e.g., resulting in a brighter image).
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: March 15, 2011
    Assignee: Northwestern University
    Inventors: Jody L. Major, Thomas J. Meade
  • Electronic Methods for the Detection of Analytes
    Publication number: 20110059535
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: May 4, 2010
    Publication date: March 10, 2011
    Applicant: Osmetech Technology Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Nucleic acid mediated electron transfer
    Patent number: 7851146
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: December 14, 2010
    Assignee: California Institute of Technology
    Inventors: Thomas J Meade, Jon Faiz Kayyem, Scott E Fraser
  • TARGETED SCHIFF BASE COMPLEXES
    Publication number: 20100298415
    Abstract: The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: March 23, 2010
    Publication date: November 25, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Allison S. Harney, Jiyoun Lee, Carole B. LaBonne, Thomas J. Meade
  • Electronic methods for the detection of analytes
    Patent number: 7759073
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: July 20, 2010
    Assignee: Osmetech Technology Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Electronic methods for the detection of analytes
    Patent number: 7713711
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 11, 2010
    Assignee: Osmetech Technology Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Nucleic Acid Mediated Electron Transfer
    Publication number: 20100069624
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Application
    Filed: October 29, 2008
    Publication date: March 18, 2010
    Applicant: California Institute of Technology
    Inventors: Thomas J. MEADE, Jon Faiz Kayyem, Scott E. Fraser
  • Detection of Analytes Using Reorganization Energy
    Publication number: 20100038262
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: August 20, 2009
    Publication date: February 18, 2010
    Applicant: Osmetech Technology Inc.
    Inventor: Thomas J. Meade
  • COMPOSITIONS AND METHODS COMPRISING MAGNETIC RESONANCE CONTRAST AGENTS
    Publication number: 20100029909
    Abstract: The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
    Type: Application
    Filed: May 26, 2009
    Publication date: February 4, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Preeti A. Sukerkar, Jiyoun Lee, Teresa K. Woodruff, Thomas J. Meade
  • Binding acceleration techniques for the detection of analytes
    Patent number: 7655129
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: February 2, 2010
    Assignee: Osmetech Technology Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen J. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Electrochemical Assay for the Detection of Enzymes
    Publication number: 20100003710
    Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 17, 2008
    Publication date: January 7, 2010
    Applicant: OHMX CORPORATION
    Inventors: Paul A. Bertin, Michael Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • CONTRAST AGENTS
    Publication number: 20090269284
    Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
    Type: Application
    Filed: September 15, 2008
    Publication date: October 29, 2009
    Applicant: Northwestern University
    Inventors: Elise A. Schultz Sikma, Mohammad Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
  • Electronic methods for the detection of analytes
    Patent number: 7601507
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: October 13, 2009
    Assignee: Osmetech Technology Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Novel Chemistry Used in Biosensors
    Publication number: 20090253149
    Abstract: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: October 17, 2008
    Publication date: October 8, 2009
    Applicant: OHMX CORPORATION
    Inventors: Michael Ahrens, Paul A. Bertin, Amanda Eckermann, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • Electronic Methods for the Detection of Analytes
    Publication number: 20090242430
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: February 5, 2009
    Publication date: October 1, 2009
    Applicant: Osmetech Technology, Inc.
    Inventors: Stephen D. O'CONNOR, Jon Faiz Kayyem, Thomas J. Meade