Patents by Inventor Thomas J. Meade

Thomas J. Meade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Paramagnetic metal-nanodiamond conjugates
    Patent number: 9125942
    Abstract: The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: September 8, 2015
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Lisa M. Manus, Daniel J. Mastarone, Dean Ho, Thomas J. Meade
  • NOVEL CHEMISTRY USED IN BIOSENSORS
    Publication number: 20150192538
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 9, 2015
    Applicant: OHMX CORPORATION
    Inventors: MICHAEL J. AHRENS, PAUL A. BERTIN, HARRY B. GRAY, THOMAS J. MEADE
  • Chemistry used in biosensors
    Patent number: 8951400
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 10, 2015
    Assignee: OHMX Corporation
    Inventors: Michael Ahrens, Paul A. Bertin, Harry B. Gray, Thomas J. Meade
  • ELECTROCHEMICAL ASSAY FOR THE DETECTION OF ENZYMES
    Publication number: 20140342383
    Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 20, 2014
    Applicant: OHMX Corporation
    Inventors: Paul A. Bertin, Michael J. Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • BACTERIA-TARGETED MAGNETIC RESONANCE CONTRAST AGENTS
    Publication number: 20140271490
    Abstract: The present invention relates to bacteria-targeted contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to bacteria targeted MRI contrast agents that can be used to detect bacteria in vivo or in vitro. In certain embodiments, the contrast agents comprise a metal chelate conjugated to at least two Zn-dipicolylamine groups.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: Northwestern University
    Inventors: Lauren M. Matosziuk, Allison S. Harney, Keith W. MacRenaris, Thomas J. Meade
  • Magnetic resonance imaging of self-assembled biomaterial scaffolds
    Patent number: 8834840
    Abstract: Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: September 16, 2014
    Assignee: Northwestern University
    Inventors: Steve R. Bull, Thomas J. Meade, Samuel I. Stupp
  • Electrochemical assay for the detection of enzymes
    Patent number: 8802390
    Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: August 12, 2014
    Assignee: OHMX Corporation
    Inventors: Paul A. Bertin, Michael Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • Electronic methods for the detection of analytes
    Patent number: 8741585
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: June 3, 2014
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • Chemistry used in biosensors
    Patent number: 8734631
    Abstract: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: May 27, 2014
    Assignee: OHMX Corporation
    Inventors: Michael Ahrens, Paul A. Bertin, Amanda Eckermann, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
  • TARGETED SCHIFF BASE COMPLEXES
    Publication number: 20130303737
    Abstract: The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: April 11, 2013
    Publication date: November 14, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Allison S. Harney, Jiyoun Lee, Carole B. LaBonne, Thomas J. Meade
  • MRI CONTRAST AGENTS
    Publication number: 20130302258
    Abstract: The present invention relates to MRI based imaging. In particular, the present invention provides MRI contrast agents targeted to a HaloTag protein with tunable relaxation properties thereby providing optimal relaxivity for low field strength imaging and the other optimal relaxivity for high field strength imaging. Moreover, the MRI contrast agents are used to detect gene expression (of a gene of interest) in real time in vivo, to detect changes in gene expression (of a gene of interest) over time in, for example, an individual organism, to detect gene expression changes (of a gene of interest) in response to therapeutics, in cell labeling for MR imaging, in clinical diagnostics, and in theranostics.
    Type: Application
    Filed: March 29, 2013
    Publication date: November 14, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Thomas J. Meade, Renee C. Strauch, Luke F. Vistain
  • Compositions and methods comprising magnetic resonance contrast agents
    Patent number: 8580231
    Abstract: The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: November 12, 2013
    Assignee: Northwestern University
    Inventors: Preeti A. Sukerkar, Jiyoun Lee, Teresa K. Woodruff, Thomas J. Meade
  • Pre-templated macromolecular architectures with multiple Gd(III) complexes and methods of use as MRI contrast agents
    Patent number: 8545813
    Abstract: The present invention relates to contrast agents for MRI and related methods of use.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: October 1, 2013
    Assignee: Northwestern University
    Inventors: Ying Song, Thomas J. Meade, Ellen Kohlmeir
  • CONTRAST AGENTS
    Publication number: 20130108554
    Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
    Type: Application
    Filed: December 19, 2012
    Publication date: May 2, 2013
    Applicant: Northwestern University
    Inventors: Elise A. Schultz Sikma, Mohammed Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
  • Electronic methods for the detection of analytes
    Patent number: 8383356
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: February 26, 2013
    Assignee: Osmetch Technology, Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade
  • COMPOSITIONS AND METHODS COMPRISING MAGNETIC RESONANCE CONTRAST AGENTS
    Publication number: 20130011340
    Abstract: The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
    Type: Application
    Filed: July 17, 2012
    Publication date: January 10, 2013
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Preeti A. Sukerar, Jiyoun Lee, Teresa K. Woodruff, Thomas J. Meade
  • Contrast agents
    Patent number: 8337813
    Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: December 25, 2012
    Assignee: Northwestern University
    Inventors: Elise A. Schultz Sikma, Mohammad Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
  • Intracellular Delivery of Contrast Agents with Functionalized Nanoparticles
    Publication number: 20120269730
    Abstract: The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.
    Type: Application
    Filed: August 9, 2010
    Publication date: October 25, 2012
    Applicant: Northwestern University
    Inventors: Chad A. Mirkin, Thomas J. Meade, Ying Song, Xiaoyang Xu
  • COMPOSITION AND METHODS FOR IMAGING CELLS
    Publication number: 20120207684
    Abstract: A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety and the second reporter moiety form a signaling complex that produces a detectable signal when the first imaging probe and second imaging probe complex with first and second biomarkers of the cell.
    Type: Application
    Filed: October 19, 2010
    Publication date: August 16, 2012
    Inventors: James Basilion, Kirti Dhingra, Thomas J. Meade, Sarah Grace Kamper
  • ELECTRONIC METHODS FOR THE DETECTION OF ANALYTES
    Publication number: 20120199499
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: February 3, 2012
    Publication date: August 9, 2012
    Applicant: Osmetech Technology Inc.
    Inventors: Stephen D. O'Connor, Jon Faiz Kayyem, Thomas J. Meade