Patents by Inventor Thomas J. Meade

Thomas J. Meade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bifunctional detection agents
    Patent number: 6521209
    Abstract: The invention provides bifunctional detection agents comprising optical dyes covalently linked to at least one magnetic resonance image (MRI) contrast agent. These agents may include a linker, which may be either a coupling moiety or a polymer.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: February 18, 2003
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Scott E. Fraser, Russell E. Jacobs
  • Novel functional agents for magnetic resonance imaging
    Publication number: 20030021750
    Abstract: The present invention is directed to non-macrocyclic functional MRI contrast agents that can be used to detect the presence of physiological target substances.
    Type: Application
    Filed: April 4, 2002
    Publication date: January 30, 2003
    Inventors: Douglas A. Bakan, Thomas J. Meade
  • Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
    Publication number: 20030004236
    Abstract: The invention relates to magnetic resonance imaging moieties, having increased in vivo residence time and amplified MRI signal, comprising a polymer and a plurality of activatable magnetic resonance imaging contrasting agents each attached to the polymer by a cleavable linkage; methods of detecting physiological signals or substances; and methods of drug delivery and drug detection for treatment of diseases.
    Type: Application
    Filed: April 22, 2002
    Publication date: January 2, 2003
    Inventor: Thomas J. Meade
  • Electrodes linked via conductive oligomers to nucleic acids
    Publication number: 20030003473
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Application
    Filed: February 20, 2002
    Publication date: January 2, 2003
    Applicant: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • High throughput screening methods using magnetic resonance imaging agents
    Publication number: 20020197648
    Abstract: The invention relates to a wide variety of different methods and compositions that find use in high throughput screening applications utilizing magnetic resonance imaging (MRI) contrast agents.
    Type: Application
    Filed: May 2, 2002
    Publication date: December 26, 2002
    Inventors: Robin M. Silva, Thomas J. Meade, Douglas A. Bakan
  • Nucleosides comprising polydentate ligands
    Patent number: 6444423
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: September 3, 2002
    Assignee: Molecular Dynamics, Inc.
    Inventors: Thomas J. Meade, Thomas W. Welch
  • Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
    Publication number: 20020098153
    Abstract: The invention relates to a novel class of magnetic resonance imaging agents that can cross the blood brain barrier and provide accurate magnetic resonance imaging of the brain, especially magnetic resonance images of amyloid deposits associated with Alzheimer's disease.
    Type: Application
    Filed: October 4, 2001
    Publication date: July 25, 2002
    Inventors: Matthew J. Allen, Scott Fraser, Russell E. Jacobs, Thomas J. Meade
  • Novel macrocyclic magnetic resonance imaging contrast agents
    Publication number: 20020049308
    Abstract: The invention relates to novel magnetic resonance imaging contrast agents.
    Type: Application
    Filed: July 17, 2001
    Publication date: April 25, 2002
    Inventors: Timothy J. Hubin, Thomas J. Meade
  • Metallic solid supports modified with nucleic acids
    Publication number: 20020034759
    Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
    Type: Application
    Filed: August 3, 2001
    Publication date: March 21, 2002
    Applicant: California Institute of Technology
    Inventors: Thomas J. Meade, Jon F. Kayyem
  • Detection of analytes using reorganization energy
    Publication number: 20020033345
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, &lgr;, of an electron transfer process
    Type: Application
    Filed: April 24, 2001
    Publication date: March 21, 2002
    Applicant: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Towards increased shelf life for cobalt(III) schiff base complexes
    Publication number: 20020013470
    Abstract: The invention relates to methods of stabilizing in an aqueous medium cobalt (III) Schiff base complexes and stabilized cobalt (III) Schiff base compounds therefrom.
    Type: Application
    Filed: April 6, 2001
    Publication date: January 31, 2002
    Inventors: Thomas J. Meade, Ofer Blum, Harry B. Gray
  • ELECTRONICS METHODS FOR THE DETECTION OF ANALYTES
    Publication number: 20020009810
    Abstract: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
    Type: Application
    Filed: June 12, 1998
    Publication date: January 24, 2002
    Inventors: STEPHEN D. O'CONNOR, JON FAIZ KAYYEM, THOMAS J. MEADE
  • METHODS OF MAKING MODIFIED NUCLEOSIDES
    Publication number: 20020004593
    Abstract: The invention is directed to novel methods of making nucleosides modified with signalling moieties and polydentate ligands, particularly for use in chelating transition metal complexes to form signalling moieties such as electron transfer moieties and fluorophores.
    Type: Application
    Filed: November 13, 1998
    Publication date: January 10, 2002
    Inventors: THOMAS J. MEADE, CHANGJUN YU
  • Nucleic acid mediated electron transfer
    Publication number: 20010046679
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Application
    Filed: April 30, 2001
    Publication date: November 29, 2001
    Applicant: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Nucleic acid mediated electron transfer
    Publication number: 20010034033
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Application
    Filed: May 23, 2001
    Publication date: October 25, 2001
    Applicant: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Metallic solid supports modified with nucleic acids
    Patent number: 6291188
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: September 18, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon F. Kayyem
  • Nucleic acid mediated electron transfer
    Patent number: 6277576
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: August 21, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Nucleic acid mediated electron transfer
    Patent number: 6268150
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Nucleic acid mediated electron transfer
    Patent number: 6268149
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Metallic solid supports modified with nucleic acids
    Patent number: 6265155
    Abstract: The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, the invention provides methods utilizing the solid supports to hybridize probe nucleic acid to target nucleic acid and methods for detecting the hybridization complex.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: July 24, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon F. Kayyem