Abstract: The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

Abstract: A bonded abrasive wheel comprises magnetizable abrasive particles retained in an organic binder. The bonded abrasive wheel has a central portion adjacent to a central hub, an outer circumference and a rotational axis extending through the central hub. The magnetizable abrasive particles adjacent to the central hub are aligned at an average angle of less than 35 degrees with respect to the rotational axis, and the magnetizable abrasive particles adjacent to the outer circumference of the bonded abrasive wheel are aligned at an average angle that is from 35 and 90 degrees, inclusive, with respect to the rotational axis. Methods of making a bonded abrasive wheel are also disclosed.

Abstract: A shaped abrasive agglomerate particle includes a shaped abrasive particle bonded in a vitreous matrix. The shaped abrasive particles have a longest particle lineal dimension on a surface and a shortest particle dimension perpendicular to the longest particle lineal dimension, and the longest particle lineal dimension is at least twice the shortest particle dimension. The shaped abrasive agglomerate particle has a longest agglomerate lineal dimension on a surface and a shortest agglomerate dimension perpendicular to the longest agglomerate lineal dimension, and the longest agglomerate lineal dimension is at least twice the shortest agglomerate dimension. The abrasive agglomerate particles are useful in abrasive articles. Methods of making the shaped abrasive agglomerate particle and abrading a workpiece are also described.

Abstract: A method of manufacturing a shaped abrasive particle is disclosed. The method includes filling a cavity of a tool with an abrasive particle precursor material. The cavity has at least an interior surface that extends downward from a tool top surface at an angle. The method also includes leveling the abrasive particle precursor material such that a top surface of the abrasive particle precursor materials is flush with the tool surface, such that a sharp portion is formed along the intersection between the sloped wall of the tool cavity and the tool surface and the sharp portion is within the same plane as the tool surface. The method also includes removing a dried abrasive particle precursor from the cavity of the tool. The abrasive particle has a sharp portion formed along the intersection between the interior surface and the tool surface.

Abstract: The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.

Abstract: An abrasive article comprises abrasive particles adhered to a substrate by a binder material. The binder material comprises an at least partially cured resole phenolic resin and an organic polymeric rheology modifier. The amount of the at least partially cured resole phenolic resin comprises from 75 to 99.99 weight percent of the combined weight of the at least partially cured resole phenolic resin and the organic polymeric rheology modifier. Methods of making the abrasive article are also disclosed.

Abstract: Abrasive articles including a nonwoven fibrous substrate having a plurality of fibers, and a multiplicity of shaped abrasive particles, each shaped abrasive particle adhered to a corresponding fiber, each shaped abrasive particle having a length (L) and a width (W) determined in a direction substantially orthogonal to the length, the ratio of the length to the width defining an aspect ratio (L/W) of at least 1.1, each abrasive particle is oriented relative to its corresponding fiber, and more than 50% of the abrasive particles are oriented with respect to their corresponding fiber such that the abrasive particle length extends generally outwardly away from a surface of the corresponding fiber as determined visually using the Orientation Test. The shaped abrasive particles may have the geometric shape of a polygonal prism having two faces and at least three sides thereon. Methods of making the abrasive articles are also disclosed.

Abstract: The present disclosure describes novel PKC-? activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

Abstract: An abrasive article comprises abrasive particles secured to a substrate by at least one binder material. The at least one binder material comprises a cured reaction product of components comprising: a) at least one phenolic resin; and b) an aqueous dispersion of at least one polyurethane, wherein, based on the total solids weight of components a) and b), the components comprise 56 to 91 percent by weight of component a) and 44 to 9 percent by weight of component b). Methods of making and using the abrasive articles are also disclosed.

Abstract: The present disclosure describes novel PKC-? activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

Abstract: Abrasive articles and associated methods are shown that include one or more camouflaging layers that can be applied to a portion of the abrasive article. The one or more camouflaging layers can be applied over the size coat layer as a discontinuous colored layer covering a portion of the size coat layer. In an example, the camouflaging layer can be applied as a repeating pattern of one or more colors on the abrasive article. In an example, the camouflaging layer can be applied randomly to the abrasive article. The discontinuous layer can have a color markedly different than a color of the size coat layer and can be used to mask or minimize an appearance of particle imperfections or voids on the abrasive article. The discontinuous layer can be applicable to coated and non-woven abrasive articles in the form of sheets, discs, belts, pads, or rolls.

Abstract: The present disclosure provides a shaped abrasive particle. The shaped abrasive particle includes a plurality of polygonal faces bound by respective polygonal perimeters and joined by at least one edge or sidewall to form the shaped abrasive particle. The shaped abrasive particle further includes a serration configured to generate a fracture along a fracture plane extending at least through the serration.

Abstract: Various embodiments of the present disclosure relate to a shaped abrasive particle transfer assembly. The shaped abrasive particle transfer assembly includes a substrate including an adhesive and a plurality of shaped abrasive particles adhered to the substrate and forming a predetermined pattern thereon.

Abstract: Coated abrasive articles having spacer particles are formed by providing a production tool having a dispensing surface with a plurality of cavities, guiding the production tool past an abrasive particle feeder, dispensing shaped abrasive particles onto the dispensing surface and into the plurality of cavities of the production tool, guiding a resin coated backing sheet adjacent the production tool past a spacer particle feeder, and dispensing spacer particles onto the resin coated backing sheet and/or the production tool after the abrasive particle feeder prior to a deposit point for the shaped abrasive particles. The spacer particles are selected to have a thickness that is greater than a thickness of a resin coating of the resin coating backing sheet and a thickness and density once dispensed that are sufficient to substantially prevent the production tool from contacting the resin coated backing sheet at the deposit point.

Abstract: Various embodiments disclosed relate to a tooling apparatus and method for providing multiple orientation cavities in tooling for abrasive particles in an abrasive article or structure. An example method includes aligning a plurality of shaped abrasive particles into a pattern, including collecting the plurality of shaped abrasive particles at least partially into cavities arranged on a dispensing surface, where at least one of the cavities is configured to allow for multiple orientations of one of the plurality of shaped abrasive particles. The pattern is transferred to a backing substrate containing a layer of adhesive, and the adhesive is cured.

Abstract: The present disclosure provides systems, devices, and methods for abrasive articles and manufacturing the same.

Abstract: A structured abrasive article comprises a plurality of shaped abrasive composites disposed on and secured to a major surface of a backing. The shaped abrasive composites comprise magnetizable abrasive particles retained in an organic binder. On a respective basis, each of the magnetizable abrasive particles has a ceramic body with a magnetizable layer disposed on at least a portion thereof. Methods of making and using the structured abrasive articles are also disclosed.

Abstract: Various embodiments disclosed relate to an abrasive article and method of forming abrasive articles using backfill to secure orientation of shaped abrasive particles. An example method includes aligning a plurality of shaped abrasive particles into a pattern, and transferring the pattern to a backing substrate containing a layer of adhesive. Prior to curing the adhesive, a plurality of backfill particles are transferred to the backing substrate, where at least some of the plurality of backfill particles are disposed between the plurality of shaped abrasive particles.

Abstract: Abrasive articles and associated methods are shown that include abrasive particles arranged in one or more symbols on a backing substrate. Examples include shaped abrasive particles arranged into one or more symbols. Other examples include one or more wear particles with a height less than other abrasive particles, such that when exposed, the wear particles indicate a wear condition of the abrasive article.

Abstract: A system and method for producing an abrasive article includes a production tool configured to provide shaped abrasive particles to a resin coated backing. A first end and a second end of the production tool are spliced together to form a spliced area. The production tool includes a dispensing surface that includes a plurality of cavities formed between the first end and the second end and configured to receive and hold the shaped abrasive particles. The resin coated backing is configured to receive the shaped abrasive particles from the dispensing surface of the production tool and configured to receive further shaped abrasive particles to fill gaps in the shaped abrasive particles caused by an absence of the plurality of cavities in the spliced area.