Abstract: Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.

Abstract: Compounds of the formula (1) in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.

Abstract: Control and/or drive device for a flying body for ejecting hot gas streams of a combusted fuel combination of at least a first and second component. Device includes a first hollow chamber body structured and arranged to contain first component, a second hollow chamber body structured and arranged to contain second component, a controllable fuel valve arranged between first hollow chamber body and second hollow chamber body to control feed of first component to second hollow chamber body, and a plurality of outlets structured and arranged to eject respective hot gas streams for influencing a flight path of flying body. Second hollow chamber body is formed as a combustion chamber for combusting the at least first and second components within second hollow chamber body to generate respective hot gas streams, and plurality of outlets are connected to the second hollow chamber body.

Abstract: Compounds of a certain formula I, in which Ra, Rb and Rc have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.

Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Abstract: Compounds of a certain formula (I) in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.

Abstract: In a method for operating a coordinate measuring machine and to a coordinate measuring machine, a coordinate measuring device, of the coordinate measuring machine is moved in at least one direction while being driven by an electric motor. An electrical drive current which flows through the electric motor for moving the electric motor and, move the coordinate measuring device is measured. A limit value for the electrical drive current is determined on the basis of a desired speed and/or on the basis of a desired acceleration with which the electric motor or the coordinate measuring device is intended to move. If the electrical drive current reaches the limit value determined and/or if the electrical drive current exceeds the limit value determined, the coordinate measuring device is changed to a predefined state, by virtue of the computer or the microcontroller switching off one of the switches disposed in the current path.

Abstract: A microorganism strain suitable for fermentative production of L-methionine and preparable from a starting strain, which comprises increased activity of a yjeH gene product or of a gene product of a yjeH homolog, compared to the starting strain.

Abstract: Compounds of a certain formula 1, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: In order to control an electromotive drive, a control unit has control modules for controlling half-bridge end power stages. Two of the control modules are pre-configured for alternatively controlling a commutator motor or a brushless electric motor via two half-bridge end power stages. A third control module can be subsequently configured to control a third half-bridge end power stage or two individual switching elements. An electromotive drive ideally can be configured with the stated control unit.

Abstract: Compounds of a certain formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, as well as salts thereof are novel effective HDAC inhibitors.

Abstract: The operating voltage is monitored in a microcontroller having associated output stages which are used to control components. In the case of over-voltage, the output stage is disconnected. Two technology-related, voltage monitoring devices working in different operating voltage ranges are provided. Due to the combination thereof, a highly precise disconnection threshold and a greater area for the operating voltage, which is to be monitored, can be obtained. If a malfunction of an over-voltage occurs, the output stages can be disconnected in a reliable manner.

Abstract: A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses an amino acid sequence which differs from the amino acid sequence of the Escherichia coli wild-type PGD (SEQ ID NO: 2) in that an amino acid apart from glycine is present at position 249 or an amino acid apart from threonine is present at position 372.

Abstract: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.

Abstract: The invention relates to compounds of formula (I) which are effective inhibitors of histone deacetylases.

Abstract: A transport cart (1) for needle boards (2) in accordance with the invention is provided with an accommodation device (8) that is designed so that its height can be adjusted and that it can also be pivoted about at least one axis, and that it is associated with a protective cover which can be moved together with the accommodation device. Numerous adjustment options, guide and stop devices are provided in order to be able to also handle large and heavy needle boards in a safe and careful manner.

Abstract: In a method for reliably monitoring the speed of a moveable coordinate measuring device, a first value of the speed is calculated from measured values of the coordinate measurement system. The measured values contain information on positions of the coordinate measuring device. The measured values are further used to determine the coordinates of a measurement object. A second value of the speed is ascertained from measurement signals of at least one additional movement sensor. The measurement signals can also be used for controlling a drive device of the coordinate measuring device. A fault signal can be generated if the first value and/or the second value deviate from one another, from a predetermined value and/or a limit value according to a predefined criterion.

Abstract: In a method for operating a coordinate measuring machine and to a coordinate measuring machine, a coordinate measuring device, of the coordinate measuring machine is moved in at least one direction while being driven by an electric motor. An electrical drive current which flows through the electric motor for moving the electric motor and, move the coordinate measuring device is measured. A limit value for the electrical drive current is determined on the basis of a desired speed and/or on the basis of a desired acceleration with which the electric motor or the coordinate measuring device is intended to move. If the electrical drive current reaches the limit value determined and/or if the electrical drive current exceeds the limit value determined, the coordinate measuring device is changed to a predefined state, by virtue of the computer or the microcontroller switching off one of the switches disposed in the current path.

Abstract: In order to control an electromotive drive, a control unit has control modules for controlling half-bridge end power stages. Two of the control modules are pre-configured for alternatively controlling a commutator motor or a brushless electric motor via two half-bridge end power stages. A third control module can be subsequently configured to control a third half-bridge end power stage or two individual switching elements. An electromotive drive ideally can be configured with the stated control unit.

Abstract: Compounds of a certain formula (I) in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.