Patents by Inventor Thomas Maier

Thomas Maier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Phthalazinone-Pyrrolopyrimidinecarboxamide Derivatives
    Publication number: 20160108049
    Abstract: The compounds of formula (1), in which R1, R7, R8, R9, R10, R17, R18, R19, R20 and m have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Application
    Filed: December 3, 2015
    Publication date: April 21, 2016
    Inventors: Thomas STENGEL, Thomas MAIER, Alexander MANN, Josef STADLWIESER, Dieter FLOCKERZI, Andreas PAHL, Ewald BENEDIKTUS, Manuela HESSMANN, Tobias KANACHER, Ragna HUSSONG, Christof ZITT, Hans Christof HOLST, Rolf-Peter HUMMEL, Martin VIERTELHAUS, Hermann TENOR, Torsten DUNKERN, Armin HATZELMANN, Christian HESSLINGER
  • Bending Frame for Extending Travel of an Actuator for a Mechanically Actuated Component
    Publication number: 20150369373
    Abstract: A bending frame extends the travel of an actuator for a mechanically actuated component. The bending frame includes a plurality of bendable longitudinal struts, which are arranged about a longitudinal axis on which the travel of the actuator runs. The longitudinal struts each extend in the direction of the longitudinal axis, and an application of force enacted by the actuator long the actuation path on the longitudinal struts causes same to bend in a direction perpendicular to the longitudinal axis. Respective cross struts extend out toward the longitudinal axis from each of the longitudinal struts, wherein a first end of a respective cross strut is articulated to a respective longitudinal strut and a second end of the respective cross strut opposite to the first end is provided in order to transmit force to the component in the direction of the longitudinal axis for the purpose of actuation thereof.
    Type: Application
    Filed: June 23, 2015
    Publication date: December 24, 2015
    Inventors: David REITH, Stephan KRAUS, Thomas MAIER
  • NOVEL SUBSTITUTED IMIDAZOQUINOLINES
    Publication number: 20150335636
    Abstract: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
    Type: Application
    Filed: June 3, 2015
    Publication date: November 26, 2015
    Applicant: 4SC AG
    Inventors: Volker GEKELER, Thomas MAIER, Astrid ZIMMERMANN, Hans-Peter HOFMANN, Sanjeev A. KULKARNI, Anil P. JAGTAP, Ganesh S. CHAURE
  • Analysis of microbes by MALDI mass spectrometry
    Patent number: 9171709
    Abstract: The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (MALDI). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as MALDI samples. The ionization by matrix-assisted laser desorption also takes place on the contact surface.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: October 27, 2015
    Inventors: Peter Lasch, Dieter Naumann, Maren Stämmler, Thomas Maier, Jens Boβmeyer
  • Call flow diagnostic system for heterogeneous networks
    Patent number: 9160619
    Abstract: A call flow diagnostic system and/or methods for monitoring, diagnosing and updating a communication network for high bandwidth, real time, feature-rich voice/video communications. An interface component is operatively coupled to the communication network. A monitoring and alert component coupled to the network devices monitors in real time transmission and device status, and the condition, state, routing, transmission, transformation settings, and packet or call routing settings of the network devices. The component collects, debugs and traces information from the network devices. A graphical user interface is coupled to the monitoring and alert component and displays information to an operator about network device status, diagnostics results, alerts, instructions in real time.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: October 13, 2015
    Assignee: Pacific Star Communications, Inc.
    Inventors: Rodney Snell, Thomas Maier
  • Valve Assembly, In Particular for Space Travel Drive Systems, Which is Closed When Not Actuated
    Publication number: 20150260300
    Abstract: A valve assembly includes an inlet and an outlet, which open into a working chamber of the valve assembly, and an actuator. In a non-actuated state of the actuator, a flow passage between the inlet and the outlet is blocked. The actuator is optionally a shape-memory actuator that can be actuated one time or comprises a shape-memory actuator, which suddenly changes its external shape upon reaching a conversion temperature, which is dependent on the alloy composition thereof, and which can be generated by a controllable electrical heating device of the valve assembly. The actuator irreversibly destroys a pipe element separating the inlet from the outlet in the working chamber upon actuation, whereby the inlet and the outlet are connected to one another with respect to flow via the working chamber.
    Type: Application
    Filed: March 10, 2015
    Publication date: September 17, 2015
    Inventors: Markus WOLF, Thomas MAIER, Stephan KRAUS
  • Single-Actuation Valve Arrangement for Aerospace Component, and Aerospace Component
    Publication number: 20150252794
    Abstract: A valve arrangement for an aerospace component includes an inlet, an outlet, and an actuator that can be actuated by a heating element. In a non-actuated state of the actuator, the valve is open to allow flow between the inlet and the outlet. The actuator is a single-use effect shape memory actuator that is compressed in the martensitic state along a longitudinal axis of the actuator and integrated into the valve arrangement. Through the activation of the heating element upon reaching a predetermined transformation temperature, the actuator undergoes a change in length, whereby it is gradually pressed against a seal seat that is embodied at the inlet or the outlet.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 10, 2015
    Inventors: Stephan KRAUS, Thomas MAIER, Markus WOLF, Georg SCHULTE
  • DETECTION OF MIXTURES IN MASS-SPECTROMETRIC MICROBE IDENTIFICATION
    Publication number: 20150211042
    Abstract: The invention relates to the identification of microbes in a sample by calculating the similarities between a mass spectrum of the sample and all reference spectra in a spectral library; it particularly concerns the detection of microbe mixtures. Microbe mixtures are probably present if several microbe species which are not closely related to each other are among the score list containing the most similar reference spectra. Methods are proposed which (1) operate with a list of the relationships, (2) determine the similarity between the reference spectra of the different microbe species of the score list, or (3) always carry out a mixture analysis in accordance with document DE 10 2009 007 266 A1 from the score list, with the generation of combination spectra, and only afterwards check the similarity of the combined spectra and thus the relationship between the microbe strains concerned.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 30, 2015
    Inventors: Jochen Franzen, Stefan Klepel, Markus Kostrzewa, Thomas Maier
  • Substituted imidazoquinolines
    Patent number: 9073913
    Abstract: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
    Type: Grant
    Filed: March 23, 2009
    Date of Patent: July 7, 2015
    Assignee: 4SC AG
    Inventors: Volker Gekeler, Thomas Maier, Astrid Zimmermann, Hans-Peter Hofmann, Sanjeev A. Kulkarni, Anil P. Jagtap, Ganesh S. Chaure
  • Method and System for Controllable Adjustment of the Removal Rate From Manually-Guided Material- and Tissue-Sectioning Tools With Effectors and a Corresponding Effector
    Publication number: 20150164527
    Abstract: Methods, systems and tools are provided for controllable adjustment of a removal rate of manually-guided material- and tissue-separating tools and effectors which allow control of the removal rate of rapidly rotating tools, without the need to significantly change the rotation speed of the tool or to significantly change the position, orientation or the geometry of the tool, and in particular, for precisely maintaining work space boundaries during material and tissue removal with tools in rapidly rotating machine tools in surgery and freehand manufacturing for producing free-form surfaces.
    Type: Application
    Filed: December 16, 2014
    Publication date: June 18, 2015
    Inventors: Thomas MAIER, Sebastian HEININGER, Erik LOEWE, Tim LUETH
  • CONTROL DEVICE, AUXILIARY CONTROL DEVICE, AND CONTROL SYSTEM FOR A TRANSMISSION OF A VEHICLE, AND METHOD FOR ASSEMBLING A CONTROL SYSTEM FOR A TRANSMISSION OF A VEHICLE
    Publication number: 20150158440
    Abstract: A control device for a transmission in a vehicle comprises numerous connecting regions for electrically connecting transmission control elements to the control device. The control device is characterized in that a first connecting region of the numerous connecting regions is designed such that both a first connecting means for establishing an electrical connection to a vehicle-transmission interface can be connected to the first connecting region in an electrically functional manner, and, alternatively, a second connecting means for establishing an electrical connection to an accessory control device can be connected to the first connecting region in an electrically functional manner. The accessory control device can be connected in an electrically functional manner to the vehicle-transmission interface by means of the first connecting means.
    Type: Application
    Filed: March 25, 2013
    Publication date: June 11, 2015
    Inventor: Thomas Maier
  • ANALYSIS OF MICROBES BY MALDI MASS SPECTROMETRY
    Publication number: 20150136972
    Abstract: The invention relates to methods for the mass spectrometric analysis of microbes, in particular to a transfer method of microbes that are required to be identified from agar plates onto mass spectrometric sample supports and their preparation for ionization by matrix-assisted laser desorption (MALDI). Microbes from microcolonies which have grown on the agar plates after a culture time of only six to eight hours are transferred with a high transfer yield onto contact surfaces of suitable size by direct contact and cell disrupted on the contact surface; the released proteins are prepared with matrix material on the contact surface as MALDI samples. The ionization by matrix-assisted laser desorption also takes place on the contact surface.
    Type: Application
    Filed: June 6, 2013
    Publication date: May 21, 2015
    Inventors: Peter Lasch, Dieter Naumann, Maren Stämmler, Thomas Maier, Jens Bossmeyer
  • 3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives
    Patent number: 9018175
    Abstract: The compounds of Formula (1), in which A, R1, R2, R3 and R5 have the meanings as given in the description, are novel effective inhibitors of type 4 and 5 phosphodiesterase.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: April 28, 2015
    Assignee: Takeda GmbH
    Inventors: Dieter Flockerzi, Thomas Stengel, Alexander Mann, Harald Ohmer, Ulrich Kautz, Steffen Weinbrenner, Stefan Fischer, Christof Zitt, Armin Hatzelmann, Torsten Dunkern, Christian Hesslinger, Thomas Maier, Hermann Tenor, Clemens Braun, Raimund Külzer, Degenhard Marx
  • Mass spectrometric identification of hyphal fungi
    Patent number: 8980577
    Abstract: A method is provided for identifying a hyphal fungus in a sample by similarity comparisons between a mass spectrum of the fungus and reference spectra. The method includes growing fresh hyphae without any adhering contact to surfaces as to form a mycelium with undifferentiated hyphae cells. A sample is prepared from the hyphae cells, and a mass spectrum is acquired of the hyphae cell sample. The mass spectrum is matched with at least one reference spectrum.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: March 17, 2015
    Assignee: Bruker Daltonik GmbH
    Inventor: Thomas Maier
  • Sulfonylpyrroles
    Patent number: 8969401
    Abstract: Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: March 3, 2015
    Assignee: 4SC AG
    Inventors: Thomas Maier, Thomas Beckers, Thomas Baer, Petra Gimmnich, Frank Dullweber, Matthias Vennemann
  • Fused pyrimidines
    Patent number: 8957064
    Abstract: Compounds of formula (I) or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6, R7, m and n have the meanings as given in the description and the claims, which are effective inhibitors of the Pi3K/Akt pathway, processes for their production and their use as pharmaceuticals.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: February 17, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Matthias Vennemann, Thomas Bär, Thomas Maier, Swen Hölder, Gerrit Beneke, Florian Dehmel, Armin Zülch, Andreas Strub, Stuart Ince, Hartmut Rehwinkel, Ningshu Liu, Ulf Bömer, Barbara Beckers
  • Device for Opening or Closing a Seal Set of a Valve
    Publication number: 20150028234
    Abstract: A device for opening or closing a seal seat of a valve arranged in a pipe for liquid or gaseous media includes a one-time only activation of the valve using a shape memory actuator. The shape memory actuator changes its external shape abruptly when a transformation temperature is reached that is dependent upon its alloy composition. The transformation temperature can be generated by a controllable electrical heating device of the device.
    Type: Application
    Filed: July 24, 2014
    Publication date: January 29, 2015
    Inventors: Stephan KRAUS, Thomas MAIER, Markus WOLF
  • Valve Assembly for Switching and/or Regulating a Medium Flow of an Aerospace Engine and Aerospace Engine
    Publication number: 20150028238
    Abstract: A valve assembly for switching and/or regulating a medium flow of an aerospace engine includes a drive, a valve and a flexible separator element. The drive includes one or more electrically actuatable actuators, which change their length in the direction of a longitudinal axis of the valve assembly when a control voltage is applied to the actuators. The valve includes a valve piston, which can be moved back and forth along the longitudinal axis by the drive and which has a valve member. The flexible separator element delimits a working space of the valve from the drive, as a result of which the medium, which flows through the valve or is present in the working space, is hermetically separated from the drive.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 29, 2015
    Inventors: Stephan KRAUS, Thomas MAIER
  • Sorting device
    Patent number: 8931616
    Abstract: A sorting device having at least one control unit for sorting mixtures of individual elements in sorting units according to at least one characterizing feature of the individual elements and having at least one conveyor belt. The sorting device comprises at least one buffer unit having at least two displaceable storage elements for intermediate storage of individual elements.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: January 13, 2015
    Assignee: BSAutomatisierung GmbH
    Inventors: Thomas Maier, Julia-Kathrin Vollmer, Carsten Vogt, Bernd Stoll
  • Acquisition technique for MALDI time-of-flight mass spectra
    Patent number: 8912485
    Abstract: The invention relates to acquisition techniques for time-of-flight mass spectra with ionization of the analyte substances by matrix assisted laser desorption. Generally speaking, these acquisition techniques involve adding together a large number of individual time-of-flight spectra, each with restricted dynamic measuring range, to form a sum spectrum. The invention provides a method that improves, in particular, the reproducibility, the concentration accuracy and therefore the ability to quantify the mass spectra. Particular embodiments also increase the dynamic range of measurement. For this purpose, multiple series of mass spectra are acquired, whereby the energy density in the laser spot is increased in discrete steps. As a result, many ion signals saturate the detector and can therefore no longer be evaluated.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: December 16, 2014
    Assignee: Bruker Daltonik GmbH
    Inventors: Thomas Maier, Jochen Franzen