Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

Abstract: An improved method for investigating a functional behavior of a component of a technical installation includes comparing a signal of the component to be investigated and representing the functional behavior of the component with a reference signal which describes an average functional behavior of identical components. During the comparison, a comparison variable describing the deviation of the signal from the reference signal is determined. In addition, a probability of the occurrence of the comparison variable is determined by using a predefinable distribution of a multiplicity of such comparative variables. A computer program and a computer readable storage medium are also provided.

Abstract: A process for producing a setting and/or curing accelerator for mineral binders is characterized in that a mineral solid is subjected to milling in a liquid medium.

Abstract: A cable connector arrangement includes a cable connector and an electrical cable with a plurality of individual lines each having a respective insulation and electrical conductor. The connector may include a front section configured for connection to a mating connector, a rear section in which the individual lines are surrounded by a cable sheath, and a central section. The electrical conductors of two individual lines have a first mutual distance in the rear section and a greater, second mutual distance in the front section with the mutual distance being increased in the central section. At least one pressing means in the central section may press at least the two individual lines together such that their insulations undergo mechanical deformation in a region of common contact.

Abstract: The invention relates to the use of carboxylic acid-based polyoxyalkylenes as low-emissions shrinkage reducers in mineral binders, to methods of reducing shrinkage and to corresponding compositions.

Abstract: In a method for the at least partially automated operation of a vehicle, a driving maneuver target is determined based on a predetermined route, a traffic situation is detected using a sensor system, for the detected traffic situation, under the specification of the driving maneuver target and multiple driving maneuver limits, a standard driving maneuver is determined based on the detected traffic situation, an anomaly indicator for the traffic situation is determined from at least one situation feature, and an exception driving maneuver is determined when a threshold value for the anomaly indicator is exceeded.

Abstract: A process for manufacturing an exhaust system, especially for an internal combustion engine of a vehicle, includes providing an exhaust gas-guiding component (26) with a wall (38) made of a metallic material and providing a sensor-mounting connector (22), to be fixed at the wall. The sensor-mounting connector includes a sensor-mounting area (28) to be positioned outside the exhaust gas-guiding component, and a connection area (34), which is to be positioned such that the connection area meshes with the wall. The connection area is pressed against an outer surface (40) of the wall of the exhaust gas-guiding component in a fastening area (39) of the wall, and at the same time rotated about a longitudinal axis (A) of the connector to penetrate into the material forming the wall and a connection in substance is established between the metallic material of the wall and the metallic material of the sensor-mounting connector.

Abstract: The assembly comprises a semiconductor device with an active-pixel array, a readout circuit chip or plurality of readout circuit chips mounted outside the active-pixel array, the readout circuit chip or plurality of readout circuit chips being configured to read out voltages or currents provided by the active-pixel array, and electric connections between the active-pixel array and the readout circuit chip or plurality of readout circuit chips.

Abstract: For a turning machine (1) that can be used for rotary turning, the tool holder (20) is hydrostatically mounted. A method corresponding to this is described, and it is provided to use a hydrostatic bearing (8, 9) for the damping of mechanical vibrations of a tool holder (20) and/or for the permanent mounting of a tool holder (20) of a turning machine (1).

Abstract: A motor vehicle for piloted driving including a front axle steering system and a rear axle steering system. In the active, trouble-free driving state with a piloted driving, the driving task for steering the front axle is performed by a front axle steering control which automatically controls the front axle steering system. A failure of the automatic front axle steering control is automatically recognized with a failure recognition device and the vehicle steering is taken over by the rear axle steering system. The motor vehicle is equipped with a device for controlled wheel-selective brake intervention. In case of a failure of the automatic front axle steering control, this device is controlled in such a way that an automatic centering of the front axle steering system is performed by wheel-selective braking interventions.

Abstract: Methods for producing an object by generative manufacturing, a component, and a computer-readable medium. In one method, a sheet-like part is formed with bulges. In another method, a supporting structure is formed with an arch formed by arch segments converging in the buildup direction and meet at an arch tip. In another method, a supporting structure is formed with a strut of a cloverleaf-like cross-sectional shape. In another method, a supporting structure is formed with a sheet-like part connected to the object and formed to project obliquely forward from the object in the buildup direction. In another method, a supporting structure is formed with a sheet-like part extending substantially along the buildup direction, the sheet-like part formed with apertures.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method is provided for measuring the viscosity of a fluid sample. The method comprising the steps of: (ii) providing a flow of the fluid sample; (iii) providing a component flow, wherein the component flow is a flow of the fluid sample further comprising a tracer component; (iv) generating a laminar flow of the flow (ii) with the flow (iii) in a diffusion channel, such as a microfluidic diffusion channel (2); (iv) measuring the lateral diffusion of the tracer component across the flows; and (v) determining the viscosity of the fluid from the measured diffusion profile, wherein the size of the tracer component is known or is determined.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: The present invention relates to a process for the production of ammonium perrhenate (APR), which includes the use of Ca(OH)2 and to ammonium perrhenate which can be obtained by the method according to the invention.

Abstract: A control valve for applying a spring-loaded brake pressure to spring-loaded parts of a rear-axle wheel brake is pneumatically activated as a function of a parking-brake braking demand and a service-brake braking demand. A first control chamber is connected via a first control piston to a control arrangement in the control valve. During an adjustment of the first control chamber via the service-brake control pressure, the spring-loaded brake pressure at the working output is a function of the service-brake control pressure or of the parking-brake control pressure. The first control piston is connected to a third control chamber, wherein the pressure in the first control chamber acts on the first control piston in one direction, and the pressure in the third control chamber acts on the first control piston in the opposite direction. The first control chamber is selectively connectable to the third control chamber via a switchable bypass valve.

Abstract: A control valve for applying a spring-loaded brake pressure to spring-loaded parts of a rear-axle wheel brake is pneumatically activated as a function of a parking-brake braking demand and a service-brake braking demand. A first control chamber is connected via a first control piston to a control arrangement in the control valve. During an adjustment of the first control chamber via the service-brake control pressure, the spring-loaded brake pressure at the working output is a function of the service-brake control pressure or of the parking-brake control pressure. The first control piston is connected to a third control chamber, wherein the pressure in the first control chamber acts on the first control piston in one direction, and the pressure in the third control chamber acts on the first control piston in the opposite direction. The first control chamber is selectively connectable to the third control chamber via a switchable bypass valve.

Abstract: A medical handle for pneumatically or hydraulically driven medical instruments or motor units includes a clutch member for mechanical and pneumatic/hydraulic coupling of a corresponding clutch member and a manually operable valve mechanism for selective pressurization of a medical instrument coupled thereto or the motor unit thereof, the valve mechanism being provided with a safety device for preventing pressurization in the case of an uncoupled medical instrument or the motor unit thereof. The clutch member present on the side of the handle is provided to interact with the valve mechanism such that during or by the mechanical coupling operation the latter is automatically opened and/or enabled for manual opening, whereas in the uncoupled state the valve mechanism is closed and/or enabling is cancelled.

Abstract: A display may have a backlight unit that provides backlight illumination. The backlight unit may include a light guide that distributes light through the display. Light-emitting diodes may emit light into the light guide. A reflector that is overlapped by the light guide may help reflect light upwards through an array of pixels. The backlight unit may have a chassis that receives the reflector, light guide, light-emitting diodes, and optical films such as diffusers and prism films. Optical and mechanical features in the backlight unit may enhance color and intensity uniformity for the backlight illumination and may help enhance durability.