Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.

Abstract: A cyclic chromatographic purification method for the isolation of a product from a feed mixture consisting of the product and at least one further component representing impurities, which impurities bind stronger to the chromatographic stationary phase than the product is given. The method uses at least two chromatographic adsorbers as chromatographic stationary phase, grouped into only one first adsorber section (1) and one second adsorber section (2), wherein if an adsorber section comprises more than one chromatographic adsorber these are permanently connected in series, wherein the first adsorber section (1) has a first adsorber section inlet and a first adsorber section outlet, and the second adsorber section (1) has a second adsorber section inlet and a second adsorber section outlet.

Abstract: The present invention relates to nanoparticles based on optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity, a method for preparing such nanoparticles, compositions comprising such nanoparticles and medical uses thereof. The invention further relates to the use of optionally alkoxylated poly(alkyl cyanoacrylates) having a defined molecular mass and dispersity for preparing nanoparticles as well as to a method for preparing such polymers.

Abstract: A process for manufacturing an exhaust system, especially for an internal combustion engine of a vehicle, includes providing an exhaust gas-guiding component (26) with a wall (38) made of a metallic material and providing a sensor-mounting connector (22), to be fixed at the wall. The sensor-mounting connector includes a sensor-mounting area (28) to be positioned outside the exhaust gas-guiding component, and a connection area (34), which is to be positioned such that the connection area meshes with the wall. The connection area is pressed against an outer surface (40) of the wall of the exhaust gas-guiding component in a fastening area (39) of the wall, and at the same time rotated about a longitudinal axis (A) of the connector to penetrate into the material forming the wall and a connection in substance is established between the metallic material of the wall and the metallic material of the sensor-mounting connector.

Abstract: A foot brake valve (2?) of a pneumatic brake system in a motor vehicle has an installation plate (4?), on which a brake pedal (14) is pivotably mounted and to which a housing (18?) of a control unit (16, 26) is fastened. A spring-loaded plunger piston (36) in actuating contact with the brake pedal (14) is guided axially movably in an annular collar (50) projecting upward out of the installation plate (4?). For fastening the housing (18?) of the control unit (16, 26) to the installation plate (4?), the housing (18?) has an intermediate flange (48) which is screw-connected to the main part of the housing (18?) and has the annular collar (50). The intermediate flange (48) is coaxially rotatably about a vertical central axis (32), and is connectable in non-positively locking fashion to the installation plate (4?) via a releasable clamping connection (62).

Abstract: The assembly comprises a semiconductor device with an active-pixel array, a readout circuit chip or plurality of readout circuit chips mounted outside the active-pixel array, the readout circuit chip or plurality of readout circuit chips being configured to read out voltages or currents provided by the active-pixel array, and electric connections between the active-pixel array and the readout circuit chip or plurality of readout circuit chips.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A process for producing doped nanoparticles, in particular for N-doped nanoparticles, includes a hydrothermal process using an organic nitrogen-containing compound or a mineral acid having at least one nitrogen atom. In particular, the photocatalytically active particles produced are characterized by a particularly high activity even in visible light.

Abstract: Monte Carlo and quasi-Monte Carlo integration are simple numerical recipes for solving complicated integration problems, such as valuating financial derivatives or synthesizing photorealistic images by light transport simulation. A drawback of a straightforward application of (quasi-)Monte Carlo integration is the relatively slow convergence rate that manifests as high error of Monte Carlo estimators. Neural control variates may be used to reduce error in parametric (quasi-)Monte Carlo integration—providing more accurate solutions in less time. A neural network system has sufficient approximation power for estimating integrals and is efficient to evaluate. The efficiency results from the use of a first neural network that infers the integral of the control variate and using normalizing flows to model a shape of the control variate.

Abstract: A control valve for applying a spring-loaded brake pressure to spring-loaded parts of a rear-axle wheel brake is pneumatically activated as a function of a parking-brake braking demand and a service-brake braking demand. A first control chamber is connected via a first control piston to a control arrangement in the control valve. During an adjustment of the first control chamber via the service-brake control pressure, the spring-loaded brake pressure at the working output is a function of the service-brake control pressure or of the parking-brake control pressure. The first control piston is connected to a third control chamber, wherein the pressure in the first control chamber acts on the first control piston in one direction, and the pressure in the third control chamber acts on the first control piston in the opposite direction. The first control chamber is selectively connectable to the third control chamber via a switchable bypass valve.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: A flexible, scalable, and fast query system for a distributed execution environment is provided. An example method includes receiving a plurality of processor summaries, each including a list of job digests, each job digest including a job identifier for a job running on a job processor and a payload portion. The method can also include, for each job digest, determining a location in a probabilistic payload data structure for the job digest and storing the payload portion and a fingerprint portion generated from a portion of a hash of the job identifier in an entry at the location as a job summary and responding to queries using the probabilistic payload data structure. Responding to a particular query may include identifying job properties corresponding to parameters of the particular query, updating job property statistics, and using the job property statistics to change the job properties represented in the payload portion.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A single-layer valve is provided. The valve comprises a microfluidic pathway at least partially defined by a flexible membrane which is configured to deform when subjected to an actuation torque, and a discontinuity bounded by a first surface. The length of the discontinuity is constant across the full width of the first surface. The valve is configured such that the actuation torque on the membrane is larger in a first direction than a second direction substantially opposite to the first direction.

Abstract: Sampling a function is used for many applications, such as rendering images. The challenge is how to select the best samples to minimize computations and produce accurate results. An alternative is to use a larger number of samples that may not be carefully selected in an attempt to increase accuracy. For a function that is an integral, such as functions used to render images, a sample distribution may be computed by inverting the integral. Unfortunately, for many integrals, it is neither easy nor practical to compute the inverted integral. Instead, warp functions may be combined to provide a sample distribution that accurately approximates the factors of the product being integrated. Each warp function approximates an inverted term of the product while accounting for the effects of warp functions approximating other factors in the product. The selected warp functions are customized or “fitted” to implement importance sampling for the approximated product.

Abstract: In order to be able to detect a possible loss of cut during the thermal separation of a workpiece as early as during the separation, the invention proposes a method for detecting an impending loss of cut or a loss of cut that has already occurred, in which energy is input into a cutting region and which comprises the following method steps: a) applying a first alternating signal to the workpiece, b) identifying a second alternating signal caused by the first alternating signal in a measurement electrode spaced apart from the workpiece, c) ascertaining the phase shift between the first and second alternating signal by outputting a phase shift signal, d) comparing the phase shift signal with a prescribed upper limit value and a prescribed lower limit value for the phase shift signal, wherein, when the phase shift signal exceeds the upper limit value or undershoots the lower limit value, the energy input is changed, for example, by stopping the thermal separation of the workpiece.

Abstract: A relay valve module for an electronically controllable pneumatic brake system for actuating wheel brakes of a utility vehicle includes: a reservoir connection for receiving a reservoir pressure; a brake control pressure connection for receiving a brake control pressure; at least one first service brake connection for outputting a service brake pressure; a relay valve with a relay valve reservoir connection, which is connected to the reservoir connection, a relay valve working connection, which is connected to the first service brake connection, a relay valve ventilation connection, and a relay valve control connection; an electropneumatic pilot control unit, which is connected to the reservoir connection, the electropneumatic pilot control unit providing a pilot control pressure; and a shuttle valve with a first shuttle valve inlet, a second shuttle valve inlet, and a shuttle valve outlet. The first shuttle valve inlet is connected to the brake control pressure connection.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.