Abstract: A dental material dispensing device has a plunger means which for dispensing the dental material is movable for urging at least one component of a dental material toward a dispensing area. The device further has cure control means with an energy source and a flow path on which the dental composition and/or the dental material flows past the energy source during dispensation. The device is operable for exposing the dental composition and/or the dental material to a specific energy by control of the energy source and/or by control of the speed of the flow of the dental composition and/or the dental material on the flow path. The device is configured for dispensing a coherent strand of dental material in a dispensing cycle. The device is further configured for operating in a first dispensing mode and additionally in a second dispensing mode during the same dispensing cycle. The ratio between the specific energy in the second dispensing mode and the specific energy in the first dispensing mode is smaller than 1.

Abstract: A component for an exhaust system of an internal combustion engine includes a component housing (22) elongated in the direction of a housing axis with an exhaust gas inlet (21) and with an exhaust gas outlet (24) and a carrier assembly unit (28) for connecting the component (16) to a carrier structure. The carrier assembly unit (28) includes a carrier rod (46), the carrier rod (46) being fixed to the component housing (22) in at least two fastening areas (60, 62) located at spaced locations from one another along the carrier rod (46). The carrier assembly unit (28) has at least one carrier rod connection area (52, 54) for connection to the carrier structure.

Abstract: The present invention relates to substituted N-heterocyclyl- and N-heteroaryltetrahydropyrimidinones of the general formula (I) or salts thereof, where the radicals in the general formula (I) correspond to the definitions given in the description, and to the use thereof as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants.

Abstract: A child seat for mounting on a motor vehicle seat is comprised of at least one contact surface device for a child accommodated in the child seat, the contact surface device having at least a first section and a second section, the second section being transferable relative to the first section from a first position to a second position by the action of an at least partially outwardly directed force acting on the second section to damp deceleration of the child in the case of a displacement of the child towards the second section.

Abstract: A securing apparatus for securing a valve lever in a set position comprises a base body; a sliding piece; and a screw element, wherein the base body and the sliding piece each have a clamping surface; wherein the sliding piece is displaceably supported at the base body along a longitudinal axis; and wherein the screw element is rotatably supported at the base body and has a thread that is in engagement with a mating thread of the sliding piece so that a position of the sliding piece relative to the base body along the longitudinal axis is restricted to a maximum spacing between the clamping surfaces that can be changed by a rotation of the screw element in order to clamp the valve lever between the clamping surfaces.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A method for monitoring, evaluating and controlling a cyclic chromatographic purification process that involves at least two adsorbers. According to the method, one step is monitoring of the chromatogram, including the measurement of at least one current concentration-proportional signal in the liquid. Another step is conducting an evaluation of the chromatogram, including a comparison of at least one of the current concentration-proportional signals measured in the monitoring step with a threshold value thereof. A further step is controlling the chromatographic purification process by adapting the termination of the currently running phase as a function of the comparison of the evaluation step and initiating the next phase. Finally, according to the method, the sequence of steps is carried out in given order at least twice.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments are described, wherein R1 is halo; R2 is halo; and Q is CH or N.

Abstract: A rolling-element bearing subassembly includes a first bearing ring having an axial face lying in a plane and a plurality of rolling elements on a running surface of the first bearing ring. The first bearing ring is connectable to a second bearing ring to form a rolling-element bearing. An annular retaining body having a first leg connected to a second leg by a bridge, the first leg being shorter than the second leg, is mounted on an axial face of the first bearing ring with the first leg contacting the axial face so that the bridge is located on a first side of the plane and the second leg extends through the plane to define an annular gap between a portion of the first bearing ring and the bridge and a portion of the second leg for retaining a lubricant.

Abstract: A fluidic device is provided. The fluidic device comprises a separation channel having at its upstream end a junction, a first channel for supplying a first fluid flow, a second channel for supplying a second fluid flow. The first and second channels meet at the junction are adapted to provide the first fluid flow in the separation channel sheathed by the second fluid flow, such that the first fluid flow does not contact the separation channel walls. The separation channel, the first and second channels are provided as a unitary piece, or where the separation channel and the first and second channels are provided as a non-unitary piece comprising a plurality of parts, the parts are of the same material.

Abstract: The present invention relates to novel monoclonal anti-human-GDF-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human GDF-15 capable of inhibiting cancer growth.

Abstract: A photoacoustic sensor device may include a housing and first and second ceramic cavity packages disposed in the housing. The first ceramic cavity package may include a first sidewall having a first set of electrical contact elements, a first cavity structure, and a light source electrically coupled to the first set of electrical contact elements. The second ceramic cavity package may include a second sidewall having a second set of electrical contact elements, a second cavity structure, and a photoacoustic detector electrically coupled to the second set of electrical contact elements. The first and second ceramic cavity packages may be arranged such that the light source and the photoacoustic detector face one another, and oriented such that the first and second sets of electrical contact elements align with electrical contact points of a PCB when the photoacoustic sensor device is positioned over the PCB for coupling to the PCB.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

Abstract: An adjuvant combination composed of a milling assistant and a concrete admixture for a composition including cement, for accelerating cement hydration, wherein the milling assistant includes at least one amino alcohol and at least one cement hydration accelerator selected from chlorides, thiocyanates, nitrates, nitrites and hydroxides, and the concrete admixture includes a reaction product of at least one calcium compound with at least one silicon compound selected from a silicon dioxide compound, a silica compound and a silicate compound. Using the adjuvant combination produces a significant acceleration in the hardening of a composition including cement, after the addition of water. This is an advantage especially in the production of prefabricated concrete components, allowing quicker deshuttering.

Abstract: A vaporiser insert for an electronic cigarette product comprises at least one electrical vaporiser for vaporising fluid supplied to the vaporiser and for supplying the vaporised fluid to an airflow, a main part having a lateral face which surrounds an airflow duct through which the airflow can flow, at least one fluid opening for supplying vaporisable fluid from the outside into the vaporiser insert and to the vaporiser being arranged on the lateral face of the main part. The vaporiser insert comprises a support for retaining the vaporiser, and the support comprises a passage opening that corresponds to the fluid opening in order to supply fluid to the vaporiser.

Abstract: The present invention features solid pharmaceutical compositions comprising Compound 1 and Compound 2. In one embodiment, the solid pharmaceutical composition includes (1) a first layer which comprises 100 mg Compound 1, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion; and (2) a second layer which comprises 40 mg Compound 2, as well as a pharmaceutically acceptable hydrophilic polymer and a pharmaceutically acceptable surfactant, all of which are formulated in amorphous solid dispersion.

Abstract: A device for controlling a fluid flow in an array of fluid pathways on a microfluidic chip is provided. The device comprising: two or more resistors provided upstream of the chip wherein each upstream resistor is configured to provide a resistance at an upstream end of a fluid pathway; two or more resistors provided downstream of the chip wherein each downstream resistor is configured to provide a resistance at a downstream end of a fluid pathway, wherein the values of the resistances are selected in order to control a proportion of fluid that flows through each fluid pathway.

Abstract: A microfluidic device (11) is provided for separation and analysis of microfluidic samples. The device comprises: a separation channel (10); a first electrolyte channel (12) configured to provide a flow of high conductivity electrolyte solution, in use; and provided with a positive electrode (13) at a downstream outlet of the channel; a second electrolyte channel (14) configured to provide a flow of high conductivity electrolyte solution, in use, and provided with a negative electrode (15) at a downstream outlet of the channel; and wherein the flow of electrolyte through the first and second electrolyte channels removes electrophoresis products and gas bubbles from the device; and wherein the presence of the electrolyte provides a substantially homogenous electric field across the separation channel.