Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: A hanging vessel includes a hanger and a containment vessel shaped as a solid of rotation having a central axis, a closed bottom, an open top, and a lower sidewall with a diameter that increases from the bottom upward. The hanger includes a first hoop located around the lower sidewall, and a second hoop located above the first hoop. The first and second hoops are open hoops having respective first and second gaps, and are connected by an intermediate section aligned with a tensile section extending from the second hoop to an attachment point on the axis above the open end. An alternative hanger has helical turns conforming to the vase. The hanger is preferably formed from a single piece of resilient wire. The vessel may be a vase having a bulbous portion that can be positively retained by the hoops or turns.

Abstract: An improved flow measuring device, such as a mass flow meter or mass flow controller, providing a high turn-down ratio as compared to prior art devices. In accordance with various embodiments of the invention, a flow sensor includes a sensor flow path that includes one or more restrictions configured to provide the sensor flow path with a non-linear relationship between a pressure drop across the sensor flow path and the flow of fluid through the flow sensor conduit. Such a flow sensor preferably achieves a high turn-down ratio by way of a variable bypass ratio that is directly proportional to the sensor tube mass flow rate so that the turn-down ratio of the mass flow controller will be ideally proportional to the square of the turndown achievable by the flow sensor conduit fluid sensing portion alone. In some embodiments, the restriction can be employed as a part of a fluid seal having an orifice and disposed between a flow sensor portion of a flow meter and a bypass portion of the flow meter.

Abstract: A method for repairing the damaged lens surface of a headlight lens, comprising the steps of, sanding the damaged lens surface of a headlight lens, applying a liquid composition to the sanded surface of the headlight lens and allowing the liquid composition to dry, wherein the liquid composition comprises a mixture of a urethane clearcoat, and an appropriate reducer. A damaged lens surface repair composition comprising a urethane clearcoat and an appropriate reducer thoroughly mixed together before application to the damaged lens surface.

Abstract: A gripping apparatus for a fork of a fork lift includes a gripping portion and at least one mounting portion for removably securing the gripping apparatus to the fork. Openings are formed between the at least one mounting portion and the gripping portion for receiving the fork therethrough. The gripping apparatus is constructed of a high friction material.

Abstract: A database query optimizer includes an access plan storage mechanism that stores execution detail corresponding to a query statement in an access plan cache. By storing execution detail in the access plan cache along with the query statement, the execution detail is available when needed to debug database problems, even after a problem occurs. The execution detail stored in the access plan cache may be mined and analyzed after-the-fact, producing a very powerful tool for debugging database problems. Snapshots of the execution detail may also be created by a user. In addition, the user may setup autonomic snapshots and comparisons so that a user may be alerted from a degradation in database performance between two snapshots.

Abstract: Database management systems and methods for searching a database are disclosed. In one embodiment, an inspector examines a plan cache or a program containing embedded queries. A plurality of similar queries is identified, and an alias is generated that satisfies the plurality of queries. The alias may be executed on a database to output a result set. Queries belonging to the alias may be executed on the result set of the alias, rather than on the database. Accordingly, efficiency is improved and runtime costs are reduced as compared to conventional database management systems.

Abstract: An ultrasonic flow sensor that includes a conduit having a length, a first ultrasonic transducer disposed at a first position along the length of the conduit, a second ultrasonic transducer disposed at a second position along the length of the conduit, the second position being spaced apart from the first position, a first reflecting interface and a second reflecting interface. The first reflecting interface is in registration with the first ultrasonic transducer to receive first acoustic energy from the first ultrasonic transducer and to reflect the first acoustic energy in a direction generally along a length of the conduit and into a fluid within the conduit. The second reflecting interface is in registration with the second ultrasonic transducer to receive second acoustic energy from the second ultrasonic transducer and to reflect the second acoustic energy in a direction generally along the length of the conduit and into the fluid within the conduit.

Abstract: A nanostructure is fabricated using charged particle deposition to deposit a catalyst on a substrate. A charged particle beam is directed to location on the substrate where the catalyst is to be deposited, with a beam-activated precursor gas also being directed to the location. For example, a nickel dot can be selectively deposited onto a substrate by using a charged particle beam to decompose a nickel-containing precursor gas, and then a carbon nanotube can be grown on the nickel dot, with the diameter of the nanotube conforming to the size of the nickel dot.

Abstract: The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.

Abstract: A system for remote monitoring and control of remotely located equipment that minimizes wireless airtime includes an interface device coupled with the remote equipment. The interface device selectively communicates over a wireless network with a central server and/or a user device. Wireless communication with the interface device is field configurable by a user to be selectively triggered base on user specified operational conditions. Communication by the interface device may be with one of a first protocol and a second protocol based on user specified operating conditions to optimize wireless airtime. The first protocol includes a user configured data string to select information to be transmitted based on the user specified operating conditions. The second protocol includes a user configurable datafile selectively transmitted over a voice channel of the wireless network based on the user specified operating conditions.

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: The present invention relates to protein microarray devices having an internal calibrator, kits containing such devices, and methods of using such devices. Such a device comprises a plurality of protein arraying pads on a support substrate, a plurality of protein arraying spots on each pad, and a calibrator disposed on each pad, each calibrator comprising a series of spots of increasing concentration of a protein. In preferred embodiments, each pad has an immunoglobulin calibrator that is of the same species as the proteins that are reactive to the protein arraying spots. An advantage of the present invention is that one can use reliably use microporous surfaces for conducting multiplexed protein microimmunoassays with an assurance as to surface-to-surface fluorescence variability on a microarray device.

Abstract: Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: A method of fabricating a nanotube probe tip and the resultant probe tip, particularly for use in an atomic force microscope. A moderately sharply peaked support structure has its tip cut or flattened to have a substantially flat end of size of about 20 to 200 nm across. The support structure may be formed by etching a conical end into a silica optical fiber. Nickel or other catalyzing metal such as iron is directionally sputtered onto the flat end and the sloped sidewalls of the support structure. The nickel is anisotropically etched to remove all the nickel from the sidewalls but leaving at least 15 nm on the flat end to form a small nickel dot. A nanotube is then grown with the nickel catalyzing its growth such that only a single nanotube forms on the nickel dot and its diameter conforms to the size of the nickel dot. In another preferred embodiment of the invention, a catalyst material can be directly deposited on to the probe end using charged particle beam deposition, such as electron beam deposition.

Abstract: A gas energy meter that acquires the data and performs the processing for an inferential determination of one or more gas properties, such as heating value, molecular weight, or density. The meter has a sensor module that acquires temperature, pressure, CO2, and speed of sound data. Data is acquired at two different states of the gas, which eliminates the need to determine the concentration of nitrogen in the gas. A processing module receives this data and uses it to perform a “two- state” inferential algorithm.

Abstract: A network gateway (1005) is described, wherein an object invocation (1020) containing an embedded object reference (1025), which points to a further object (1002), is modified on passing through the gateway. The gateway validates the object invocation and enacts a number of security tests thereon before forwarding it on. In preferred embodiments, the embedded object reference is replaced by an object reference (1035) to a gateway proxy specifically for the further object (1002). The replacement object reference (1035) also includes enough information that the original object reference (1025) can be recovered. The gateway proxy is generated on or after receipt of the invocation (1020). In the event the further object (1002), which was the subject of the object reference, is itself invoked, the invocation is directed to the gateway proxy, which in turn recovers the original object reference and forwards the invocation on to the further object (1002).

Abstract: The present invention relates to substituted pyrazolyl derivatives, compositions comprising such, intermediates, methods of making substituted pyrazolyl derivatives, and methods for treating cancer, inflammation, and inflammation-associated disorders, such as arthritis.

Abstract: The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.