Abstract: Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

Abstract: An apparatus, program product and method represent a database query access plan a query execution data structure including a plurality of query node objects arranged into a tree relationship to define a parent node object and at least one child node object, and an attribute data structure that references a plurality of attributes utilized by the query execution data structure. At least one of the parent and child node objects includes an attribute operation data structure configured to manipulate at least a subset of the plurality of attributes in the attribute data structure by accessing the attribute operation data structure. By partitioning the functionality of a query access plan into a collection of node objects and an attribute data structure, and then providing within at least a subset of the node objects attribute operation data structures that manipulate the attribute data structure, the resulting query engine architecture becomes significantly extendible and adaptable.

Abstract: A method, used in connection with a pulse-echo type sensor for determining the speed of sound in a gas, for improving the accuracy of speed of sound measurements. The sensor operates on the principle that speed of sound can be derived from the difference between the two-way travel time of signals reflected from two different target faces of the sensor. This time difference is derived by computing the cross correlation between the two reflections. The cross correlation function may be fitted to a parabola whose vertex represents the optimum time coordinate of the coherence peak, thereby providing an accurate measure of the two-way time diffference.

Abstract: A method of fabricating a nanotube probe tip and the resultant probe tip, particularly for use in an atomic force microscope. A moderately sharply peaked support structure has its tip cut or flattened to have a substantially flat end of size of about 20 to 200 nm across. The support structure may be formed by etching a conical end into a silica optical fiber. Nickel or other catalyzing metal such as iron is directionally sputtered onto the flat end and the sloped sidewalls of the support structure. The nickel is anisotropically etched to remove all the nickel from the sidewalls but leaving at least 15 nm on the flat end to form a small nickel dot. A nanotube is then grown with the nickel catalyzing its growth such that only a single nanotube forms on the nickel dot and its diameter conforms to the size of the nickel dot. In another preferred embodiment of the invention, a catalyst material can be directly deposited on to the probe end using charged particle beam deposition, such as electron beam deposition.

Abstract: The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.

Abstract: A weak record locking scheme that, while enforcing serialization of record updates, permits a read to extract data from uncommitted updates. Specifically, records are locked in association with a process or thread performing a lock. When the records affected by a transaction are initially locked for reading or updating, they are locked at the process level. When a particular record is to be read or updated as part of a transaction, it is locked at the thread level. A read transaction that will accept uncommitted changes uses a weak lock to lock the record for reading. A weak lock may be made on a record so long as the record is not already locked for updating at the thread level. While a record is weakly locked for reading, it cannot be locked for updating at the thread level. A record may thus be weakly locked even though the record is locked for updating at the process level by the same process. Weak locking thus preserves serialization of updates, while reducing delays caused by locking conflicts.

Abstract: Disclosed are compounds Formula I 1

Abstract: An apparatus, program product and method represent a database query access plan a query execution data structure including a plurality of query node objects arranged into a tree relationship to define a parent node object and at least one child node object, and an attribute data structure that references a plurality of attributes utilized by the query execution data structure. At least one of the parent and child node objects includes an attribute operation data structure configured to manipulate at least a subset of the plurality of attributes in the attribute data structure by accessing the attribute operation data structure. By partitioning the functionality of a query access plan into a collection of node objects and an attribute data structure, and then providing within at least a subset of the node objects attribute operation data structures that manipulate the attribute data structure, the resulting query engine architecture becomes significantly extendible and adaptable.

Abstract: A probe having a probe tip, especially for use in an atomic force microscope, formed by micromachining techniques in a silicon wafer. The tip is photolithographically defined in a layer, preferably of silicon nitride deposited on the silicon wafer, and has a width and thickness of usually less than 250 nm. Thereby, the probe tip can be formed to have a generally square cross section in which one lateral dimension is determined by the layer thickness, and the other lateral dimension by the photolithography or by a subsequent step of focused ion beam milling. The portion of the silicon wafer underlying the area probe tip is etched away, preferably before the probe tip is etched, but another portion of the silicon is left to serve as a support at the base of the probe tip. A hinge may be formed in the silicon wafer, and the probe tip together with a robust shank can be made to rotate to a direction perpendicular to the wafer surface.

Abstract: A weak record locking scheme that, while enforcing serialization of record updates, permits a read to extract data from uncommitted updates. Specifically, records are locked in association with a process or thread performing a lock. When the records affected by a transaction are initially locked for reading or updating, they are locked at the process level. When a particular record is to be read or updated as part of a transaction, it is locked at the thread level. A read transaction that will accept uncommitted changes uses a weak lock to lock the record for reading. A weak lock may be made on a record so long as the record is not already locked for updating at the thread level. While a record is weakly locked for reading, it cannot be locked for updating at the thread level. A record may thus be weakly locked even though the record is locked for updating at the process level by the same process. Weak locking thus preserves serialization of updates, while reducing delays caused by locking conflicts.

Abstract: A method of fabricating a carbon nanotube probe tip and the resultant probe tip, particularly for use in an atomic force microscope. A moderately sharply peaked support structure has its tip cut or flattened to have a substantially flat end of size of about 20 to 200 nm across. The support structure may be formed by etching a conical end into a silica optical fiber. Nickel or other catalyzing metal such as iron is directionally sputtered onto the flat end and the sloped sidewalls of the support structure. The nickel is anisotropically etched to remove all the nickel from the sidewalls but leaving at least 15 nm on the flat end to form a small nickel dot. A carbon nanotube is then grown with the nickel catalyzing its growth such that only a single nanotube forms on the nickel dot and its diameter conforms to the size of the nickel dot.

Abstract: The present invention relates to an interactive computer system and method for collecting and analyzing user response data. The system includes a portable, compact re-programmable data device, the user interface of which is defined via an input program created on a computer and transferred from it to the data device. The user response data collected by the data device is transferred to an output table stored in the computer which is directly created from the input program without the need for additional programming. The user response data stored in the output table may then be analyzed via a data analysis mechanism also stored in the computer. The data analysis mechanism includes data analysis software and a plurality of customizable data analysis templates stored separately from the data analysis software, such that a data analyst can automatically and selectively configure the data analysis mechanism without the need for additional programming.

Abstract: The present invention provides isolated baboon and cynomolgus macaque EP4 protein, DNA molecules encoding said protein, vectors and cells carrying said DNA molecules, specific bind partners for the protein, and methods of determining ligands for baboon and cynomolgus macaque EP4.

Abstract: The present invention provides isolated chimpanzee EP4 protein, DNA molecules encoding said protein, vectors and cells carrying said DNA molecules, specific binding partners for the protein, and methods of determining ligands for chimpanzee EP4.

Abstract: A method for providing a backup server to a primary server includes operating a first server such that the first server communicates with a network and is associated with a primary server address. A second server is also maintained, configured in parallel with the first server, and associated with a monitor server address. The monitor server includes periodically signaling the primary server address, watching to determine whether a response to the signal is received within a predetermined time period, and repeating the signaling and watching until a time period elapses where the response is not received within the time period. If a response is not received, the first server is rebooted and the second server assumes the role of the primary server.

Abstract: A probe tip manufactured from a conically shaped quartz tip etched to a fine apex. The quartz tip is coated with about 1 &mgr;m of a hard material such as silicon nitride. A probe tip having dimensions of about 100 nm×1 &mgr;m is then machined from the hard material adjacent to the apex of the quartz tip along the axis of the quartz tip. The machining is preferably performed by focused ion beam milling.

Abstract: A system for allowing a computer application or computer service to notify a user 10 that his certificate is within some specified interval before its expiry date utilizing information that is already contained in a standard digital certificate, together with current data information that is already known by the application 12 or service 16 to enforce expiry of the certificate when it occurs. No additional storage of information is required.

Abstract: The present invention provides isolated canine AR protein, DNA molecules encoding said protein, vectors and cells carrying said DNA molecules, specific bind partners for the protein, and methods of discovering ligands for canine AR.

Abstract: The invention provides osteoactivin proteins and nucleic acid molecules that encode the same, as well as biologically functional expression vectors containing nucleic acid molecules encoding osteoactivin proteins, and antibodies specific for osteoactivin proteins. The invention also provides therapeutic and diagnostic compositions and methods for utilizing the proteins, antibodies, nucleic acids, and vectors of the invention, for example, to modulate bone formation.

Abstract: The present invention provides isolated canine PTH1 protein, DNA molecules encoding said protein, vectors and cells carrying said DNA molecules, specific bind partners for the protein, and methods of discovering ligands for canine PTH1.