Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.

Abstract: A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

Abstract: The present invention relates to methods for determining the presence and/or amount of multiple nucleic acids in a sample.

Abstract: A method includes forming a composition of matter including an amount of a reporter compound, a binding member capable of capturing the reporter compound, and an amount of a target nucleic acid capable of forming complexes with the reporter compound.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: In order to perform relatively frequent, zero-downtime software updates, a bridge schema corresponding to an original schema of a database system may be generated. Within the bridge schema, a plurality of views corresponding to a plurality of database tables of an application executing on an application server may be generated. A connection from the application to the original schema may be changed to the bridge schema, to thereby continue executing the application using the plurality of views. When a change file defining update changes to at least one original database table of the plurality of database tables is received, content of the at least one original database table may be synchronized with a target table reflecting the update changes. Then, the connection may be changed back to the original database schema to continue executing the software application, using the plurality of database tables and including the target table.

Abstract: Methods, systems, and computer-readable storage media for applying corrections during an upgrade procedure of a software management system include actions of receiving a set of white-listed object types, receiving a set of corrections to be imported, the set of corrections including a set of objects, to which corrections are to be applied during the upgrade procedure, determining a set of object types included in the set of corrections, the set of object types including one or more object types, and selectively permitting one or more transport requests to effect corrections of the set of corrections to be issued during the upgrade procedure based on the set of object types and the set of white-listed object types.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

Abstract: The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.

Abstract: Methods, systems, and computer-readable storage media for applying corrections during an upgrade procedure of a software management system include actions of receiving a set of white-listed object types, receiving a set of corrections to be imported, the set of corrections including a set of objects, to which corrections are to be applied during the upgrade procedure, determining a set of object types included in the set of corrections, the set of object types including one or more object types, and selectively permitting one or more transport requests to effect corrections of the set of corrections to be issued during the upgrade procedure based on the set of object types and the set of white-listed object types.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Abstract: A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative for the presence and/or amount of the target molecules, a microfluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the microfluidic network.

Abstract: The present invention provides a compound of formula (I) in free form or in pharmaceutically acceptable salt form a method for manufacturing the compound of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and pharmaceutical compositions.

Abstract: The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.

Abstract: The present invention relates to a pharmaceutical composition in solid oral dosage form comprising (R)-7-(2-(1-(4-butoxyphenyl)-2-methylpropan-2-ylamino)-1-hydroxyethyl)-5-hydroxybenzo[d]thiazol-2(3H)-one acetate salt.

Abstract: The present invention relates to methods for determining the presence and/or amount of multiple nucleic acids in a sample.

Abstract: Various techniques are described for precisely locking database objects within a database during a system upgrade with the use of database freeze triggers. Some database freeze triggers can be utilized to lock transport requests while other database freeze triggers can be utilized to lock database objects such as exchange tables. For transport requests, techniques describe the use of a whitelist identify transport objects or transport object types which shall remain unblocked. As a result, a database freeze trigger can be generated for transport objects or transport object types that are not included in the whitelist. For database objects, techniques describe the identification of a tool or service which has been allowed during the upgrade. Database objects which can be modified during execution of the tool or service can be identified. Database freeze triggers can be generated for the database objects besides those identified.